Nocturnal Diarrhea in Diabetes Mellitus

Gastric Emptying in Diabetes Mellitus

“…It is often combined with gastric retention. Muri (1953) reports a case of gastric retention and diarrhoea in which laparotomy was performed as gastro-colonic fistula was suspected. The surgeon found a pronounced hypermotility in the intestine.…”

Neostigmine-induced contraction and nitric oxide-induced relaxation of isolated ileum from STZ diabetic guinea pigs

“…Increased colonic motility in response to gastric distension, the parasympathetic gastrocolonic reflex, was absent in patients with DM reporting severe constipation (Battle et al, 1980; Battle et al, 1983). Diabetic diarrhea has been associated with autonomic neuropathy (Ellenberg, 1964; McNally et al, 1969; Scarpello et al, 1976; Whalen et al, 1969) with predominantly reports of slowed intestinal transit (Hodges et al, 1947; Iber et al, 1993; Scarpello et al, 1976; Whalen et al, 1969), but occasionally reports of accelerated intestinal transit (Muri, 1953; Vinnik et al, 1962). Hence, inappropriate postprandial intestinal motility may be the consequence of inadequate activation of extrinsic parasympathetic reflex pathways by disordered gastric motility (Kumar et al, 2008; Rosztoczy et al, 2004; Samsom et al, 1995; Samsom et al, 1996; Samsom et al, 1998; Troncon et al, 1998) or by abnormal gastric emptying (Maggs et al, 2008; Sarosiek et al, 2010), and may result in inappropriate gastric emptying through an ineffective ileal brake reflex as observed in streptozotocin (STZ) rats (Martin et al, 2004).…”

Προσβολη Του Κυκλοφορικου Συστηματος Απο Αυτονομη Νευροπαθεια Σε Διαβητικα Ατομα

“…Ή χοληδόχος δυνατόν νά διαταθεί δύο έως τρεις φορές περισσότερο τοΰ φυσιολογικού μεγέθους (Gitelson et al 1969, Bloom et al 196 e ). (Katz et al 1966, Sheridan et al 1946, Muri 1953, Malins et al 1957.…”