Nocturnal Enuresis in Children with Sickle Cell Anemia

Uwaezuoke, Samuel N; Eneh, Chizoma I; Ezenwosu, Osita U; Ndu, Ikenna K

doi:10.5772/intechopen.81578

Cited by 3 publications

(7 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Breastfeeding during infancy is associated with multiple benefits, including protection against diabetes in both mother and child (11)(12)(13). In mammals, alkylglycerols (AKGs) can be produced and secreted from lactating mammary gland cells (14).…”

Section: Alkylglycerols Maintain Beat In Infant Atmentioning

confidence: 99%

Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

Gliniak

Scherer²

2019

Journal of Clinical Investigation

View full text Add to dashboard Cite

Section: Alkylglycerols Maintain Beat In Infant Atmentioning

confidence: 99%

Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

Gliniak

Scherer²

2019

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…2 Enuresis is more common in children with SCD than in those with normal hemoglobin; however, prevalence rates vary widely, ranging from 26.4% to 51% depending on study methodology and enuresis definition criteria. 3 SCD is a multisystem disease, with one of the most typically afflicted organs being the kidneys due to medullary ischemia and infarction. The underlying etiopathogenesis of enuresis in SCD is not fully known.…”

Section: Introductionmentioning

confidence: 99%

“…The underlying etiopathogenesis of enuresis in SCD is not fully known. It has been related to tubular dysfunction manifested as defects in urinary concentration (hyposthenuria) and acidification, 4 low functional bladder capacity and high overnight urine volume, 3,5 glomerular hyperfiltration caused by increased prostaglandin production. 6 Eneh et al, on the other hand, revealed that enuresis in children with SCD is related to other causative variables that are common in the general population rather than hyposthenuria.…”

Section: Introductionmentioning

confidence: 99%

“… 2 Enuresis is more common among children with SCD compared to those with normal haemoglobin; however, prevalence rates vary widely, ranging from 26.4–51%, depending on study methodology and enuresis definition criteria. 3 …”

mentioning

confidence: 99%

“…It has been related to tubular dysfunction manifested as defects in urinary concentration (hyposthenuria) and acidification, low functional bladder capacity and high overnight urine volume and glomerular hyperfiltration caused by increased prostaglandin production. 3 – 6 Eneh et al ., on the other hand, revealed that enuresis in children with SCD is related to other causative variables that are common in the general population as opposed to hyposthenuria. 7 Similarly, other studies have found that potential mechanisms underlying nocturnal enuresis in patients with normal haemoglobin genotype (haemoglobin AA) are equally relevant in SCD patients.…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Role of Hyposthenuria in Enuresis among Paediatric Patients with Sickle Cell Disease

Al‐Asadi

Radhi

Hassan

et al. 2022

Sultan Qaboos Univ Med J

View full text Add to dashboard Cite

Objectives: Enuresis in children with sickle cell disease (SCD) is common. Many risk factors have been postulated but its relation to hyposthenuria is debatable. This study aims to determine the prevalence of enuresis inchildren with SCD in Basrah, Iraq and to examine its relation with hyposthenuria. Methods: A cross-sectional epidemiological study was performed on children with SCD who met the inclusion criteria at the Basrah Center for Hereditary Blood Diseases over the period from the first of December 2020 through May 2021. A questionnaire was used to collect relevant data. Blood samples were tested for hemoglobin genotype, certain blood indices, and serum hemoglobin. Urine was tested for albumin and creatinine, and the specific gravity was measured using urine dipsticks. The relationships between enuresis and various sociodemographic and clinical variables were assessed. Binary logistic regression analysis was done to examine the independent risk factors of enuresis. Results: Out of 200 eligible children, 161 were studied after exclusion of 39 based on the exclusion criteria, yielding an 80.5% response rate, 60.9% of them were males. The mean age of the participants was 10.9 ± 2.9 years. Enuresis was reported in 50 (31.1%) patients. The independent risk factors for enuresis were; family history of enuresis (OR, 5.94; 95% CI, 2.54-13.89; P<0.001), hyposthenuria (OR, 3.76, 95% CI, 1.25-11.30; P= 0.018), and sleep disorders (OR, 2.90; 95% CI, 0.19-7.06; P= 0.019). Conclusion: Enuresis is common among children with SCD. Hyposthenuria was significantly associated with enuresis. Family history of enuresis, and sleep disorders were also found to be significantly related to enuresis. Keywords: Enuresis, sickle cell disease, children, prevalence, hyposthenuria

show abstract

Prevalence and factors associated with Enuresis among children with Sickle Cell Anaemia attending Sickle Cell Clinic at Mulago National Referral Hospital; A Cross sectional study.

Kuteesa,

Abbo,

Kasirye

et al. 2023

Preprint

View full text Add to dashboard Cite

Background:Sickle cell anaemia (SCA) can lead to complications in almost all body organs and the kidneys are frequently affected due to medullary infarction that occurs as a result of sickling events thus leading to hyposthenuria as well as renal tubular acidosis that in turn lead to enuresis. Globally the prevalence of enuresis in SCA ranges from 25% to 50.9% but the burden is not known in Uganda. We set out to determine the prevalence and factors associated with enuresis in SCA. Methods: A cross-sectional study was conducted at the Mulago sickle cell clinic between December 2020 and January 2021. Consecutive enrolment of children aged 5-17 years confirmed to have SCA by hemoglobin electrophoresis was done. Information on prevalence and factors associated with enuresis was collected using structured questionnaires. Urinalysis and RFTs were done in those found with enuresis. Qualitative data regarding responses to enuresis was collected using in depth interviews with caregivers and children. Bivariate and Multivariate analysis using logistic regression models were utilized to determine the factors associated with enuresis. Qualitative data was analysed using content thematic approach. Results: We enrolled 404 children aged 5- 17, half of whom (52.5%) were male. Median age (IQR) was 8(7-11). One in four children had enuresis (26.2%) (95%CI: 22.2-30.8). All had primary enuresis and 90% had monosymptomatic enuresis. Age 5-7years aOR:2.03(95%CI:1.11-3.72) P value=0.022 and sibling history of bedwetting aOR:1.87(95%CI:1.08-3.24) P value=0.026 were significantly associated with enuresis while female gender aOR:0.58(95%CI:0.36-0.98) p value = 0.025 and fourth or higher birth order aOR:0.41(95%CI:0.22-0.78) P value= 0.007 were protective factors. Most caretakers had done nothing regarding bedwetting while others had used cultural practices and behavioral interventions but none had talked to a health worker about bedwetting and none had used enuresis alarms or medications. Conclusion: The prevalence of enuresis in children with SCA was 26.2% which is high. Enuresis was associated with family history of bedwetting and younger age of 5-7 years while female gender and fourth or higher birth order were protective factors. Few caregivers employed strategies that included cultural and behavioral interventions.

show abstract

Nocturnal Enuresis in Children with Sickle Cell Anemia

Cited by 3 publications

References 55 publications

Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood

The Role of Hyposthenuria in Enuresis among Paediatric Patients with Sickle Cell Disease

Prevalence and factors associated with Enuresis among children with Sickle Cell Anaemia attending Sickle Cell Clinic at Mulago National Referral Hospital; A Cross sectional study.

Contact Info

Product

Resources

About