Nocturnal Hypoxia and Arterial Lactate Levels in Sleep-Related Breathing Disorders

Uçar, Zeynep Zeren; Taymaz, Zühre Sarp; Erbaycu, Ahmet Emin; Kıraklı, Cenk; Tuksavul, Fevziye; Güçlü, Salih Zeki

doi:10.1097/smj.0b013e3181a93897

Cited by 10 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Morning lactate was demonstrated to be significantly higher in patients with sleep-related breathing disorders in a recent study. 18 However, no such study is available in which both UA and lactate levels are carried out simultaneously in patients and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serum uric acid and lactate levels among patients with obstructive sleep apnea syndrome: Which is a better marker of hypoxemia?

Hira

Shukla

Kaur

et al. 2012

Annals of Saudi Medicine

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVESTissue hypoxia due to repeated sleep apneas leads to increased serum levels of uric acid (UA) and lactate in patients with obstructive sleep apnea syndrome (OSAS). Studies on assessment of serum level of UA in patients of OSAS are available. However, research on simultaneous evaluation of levels of serum lactate and UA is lacking.DESIGN AND SETTINGProspective, case-control study.PATIENTS AND METHODSForty patients suffering from OSAS, diagnosed by night polysomnography (PSG), were included in this study. Forty age- and sex-matched subjects in whom the presence of OSAS was ruled out by night PSG were included as healthy controls. Participants underwent a procedure for the measurement of serum UA and lactate before and after sleep.RESULTSBoth before and after sleep UA levels of patients with OSAS were found to be significantly higher (P=.001 and .002, respectively) as compared to UA levels of controls. A statistically significant (P=.02) overnight (after sleep) rise was observed in the serum lactate level of OSAS patients. The correlation between serum UA values and %TSTs (percentage of total sleep time spent) below 95% SaO2 (arterial oxygen saturation) (P=.02) was statistically significant. The correlation was positive with %TSTs below 90% SaO2, whereas it was found negative with normal basal oxygen. No significant correlation was observed between serum UA and the AHI (apnea-hypopnea index). Polysomnographic variables failed to show significant correlation with serum UA on respective multiple regression models controlling for age, body mass index, and waist-hip ratio. However, plasma lactate levels after sleep correlated with %TSTs below 95% of SaO2 and AHI with P values of .02 and .01, respectively.CONCLUSIONSBoth serum UA and lactate were positively correlated with the degree of hypoxia in OSAS. The measurement of serum lactate level was a better marker of oxidative stress among patients with OSAS.

show abstract

Section: Discussionmentioning

confidence: 99%

“… 11 – 17 Studies related to the measurement of the serum lactate level in OSAS patients are very few. In 2009, Ucar et al 18 demonstrated a relationship between nocturnal hypoxia and arterial lactate levels in sleep-related breathing disorders.…”

mentioning

confidence: 99%

Serum uric acid and lactate levels among patients with obstructive sleep apnea syndrome: Which is a better marker of hypoxemia?

Hira

Shukla

Kaur

et al. 2012

Annals of Saudi Medicine

View full text Add to dashboard Cite

show abstract

“…Morning lactate levels are modestly elevated in OSA. 161,162 During exercise, subjects with OSA show impaired aerobic and glycolytic capacity, a finding similar to that seen at high altitude. 163 In addition, OSA severity correlates modestly with hematocrit level, 164 although the disease rarely leads to polycythemia.…”

Section: Links Between Osa and Tissue Hypoxiamentioning

confidence: 66%

Metabolic dysfunction in obstructive sleep apnea: A critical examination of underlying mechanisms

Mesarwi

Sharma

Jun

et al. 2014

Sleep and Biological Rhythms

View full text Add to dashboard Cite

It has recently become clear that obstructive sleep apnea (OSA) is an independent risk factor for the development of metabolic syndrome, a disorder of defective energy storage and use. Several mechanisms have been proposed to explain this finding, drawing upon the characteristics that define OSA. In particular, intermittent hypoxia, sleep fragmentation, elevated sympathetic tone, and oxidative stress – all consequences of OSA – have been implicated in the progression of poor metabolic outcomes in OSA. In this review we examine the evidence to support each of these disease manifestations of OSA as a unique risk for metabolic dysfunction. Tissue hypoxia and sleep fragmentation are each directly connected to insulin resistance and hypertension, and each of these also may increase sympathetic tone, resulting in defective glucose homeostasis, excessive lipolysis, and elevated blood pressure. Oxidative stress further worsens insulin resistance and in turn, metabolic dysfunction also increases oxidative stress. However, despite many studies linking each of these individual components of OSA to the development of metabolic syndrome, there are very few reports that actually provide a coherent narrative about the mechanism underlying metabolic dysfunction in OSA.

show abstract

“…The present study found that nocturnal hypoxemia may be involved in the pathophysiology of PLMS. Similarly, a study performed by Ucar et al [26] proved the hypothesis that hypoxia can also prompt PLMs in addition to other factors, e.g., anemia, chronic uremia, other metabolic disorders, and medications, although overnight lactate level has no effect on the occurrence of PLMS.…”

Section: Discussionmentioning

confidence: 86%

Periodic limb movement index and severity of obstructive sleep apnea

et al. 2022

View full text Add to dashboard Cite

Background Periodic limb movements during sleep (PLMS) and obstructive sleep apnea syndrome (OSAS) are two frequent coincident sleep disorders. The association of PLMS with OSAS severity and predictors of PLMS in OSAS patients were investigated. Material and method This is a retrospective study that enrolled adult patients ≥ 16 years old who visited the sleep unit at Mouwasat Hospital, Saudi Arabia, between January 2021 and October 2021. All were subjected to full medical history, clinical examination, Epworth Sleepiness (ESS), STOP-Bang questionnaires, and standard overnight polysomnography. Subjects were subdivided into two groups based on PSG findings: group I, OSA patients (153). Patients were classified into mild n = 57 (AHI ≥ 5 and < 15), moderate n = 35 (AHI ≥ 15 and < 30), and severe n = 61 (AHI ≥ 30). Group II, control group included 100 subjects. Result There was a higher frequency of PLMS in OSA patients vs control group (with a statistically significant value). The study showed a statistically significantly positive correlation between PLMI and each of AHI, hypopnea index, desaturation index, and PLMs with arousal index, in contrast; it had a statistically significantly negative correlation with BMI among the OSA group. By performing multivariate logistic regression to predict the possible factors associated with the existence of PLMS among the OSA group, it was showed that the apnea index and desaturation index were statistically significant predictors. Conclusion The present study showed that OSA patients with PLM were older; had greater AHI, hypopnea index, desaturation index, and PLMs with arousal index; and had lower BMI. Further studies are needed for better understanding this complex relationship.

show abstract

Nocturnal Hypoxia and Arterial Lactate Levels in Sleep-Related Breathing Disorders

Abstract: As a marker of tissue hypoxia, arterial lactate may be used to assess the severity of SRBD.

Cited by 10 publications

References 33 publications

Serum uric acid and lactate levels among patients with obstructive sleep apnea syndrome: Which is a better marker of hypoxemia?

Serum uric acid and lactate levels among patients with obstructive sleep apnea syndrome: Which is a better marker of hypoxemia?

Metabolic dysfunction in obstructive sleep apnea: A critical examination of underlying mechanisms

Periodic limb movement index and severity of obstructive sleep apnea

Contact Info

Product

Resources

About