Nocturnal Periodic Breathing during Acclimatization at Very High Altitude at Mount Muztagh Ata (7,546 m)

Bloch, Konrad E.; Latshang, Tsogyal D.; Turk, Alexander; Heß, Thomas; Hefti, Urs; Merz, Tobias M.; Bosch, Martina M.; Barthelmes, Daniel; Hefti, Jacqueline Pichler; Maggiorini, Marco; Schoch, Otto D.

doi:10.1164/rccm.200911-1694oc

Cited by 110 publications

(105 citation statements)

References 31 publications

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“…Obesity is known to cause increased hypoxia owing to sleep apnea and thereby may create a mood disturbance (Rigby et al, 2004); one might anticipate that the altitudesuicide finding might be heightened in obese individuals. Known periodic breathing at high altitude may further exacerbate the effects of sleep apnea and nocturnal hypoxia (West et al, 1986, Khoo et al, 1996Bloch, 2010).…”

Section: Us Suicide Rates Increase With Altitudementioning

confidence: 99%

Positive Association between Altitude and Suicide in 2584 U.S. Counties

Brenner

Cheng

Clark

et al. 2011

High Altitude Medicine & Biology

115

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Positive association between altitude and suicide in 2584 U.S.counties. High Alt. Med. Biol. 12: 31-35, 2011.-Suicide is an important public health problem worldwide. Recent preliminary studies have reported a positive correlation between mean altitude and the suicide rate of the 48 contiguous U.S.states. Because intrastate altitude may have large variation, we examined all 2584 U.S. counties to evaluate whether an independent relationship between altitude and suicide exists. We hypothesized that counties at higher elevation would have higher suicide rates. This retrospective study examines 20 yr of county-specific mortality data from 1979 to 1998. County altitude was obtained from the U.S. Geologic Survey. Statistical analysis included Pearson correlation, t tests, and multivariable linear and logistic regression. Although there was a negative correlation between county altitude and all-cause mortality (r ¼ À0.31, p < 0.001), there was a strong positive correlation between altitude and suicide rate (r ¼ 0.50, p < 0.001). Mean altitude differed in the 50 counties, with the highest suicide rates compared to those with the lowest rates (4684 vs. 582 ft, p < 0.001). Controlling for percent of age >50 yr, percent male, percent white, median household income, and population density of each county, the higher-altitude counties had significantly higher suicide rates than the lower-altitude counties. Similar findings were observed for both firearm-related suicides (59% of suicides) and nonfirearm-related suicides. We conclude that altitude may be a novel risk factor for suicide in the contiguous United States.

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Section: Us Suicide Rates Increase With Altitudementioning

confidence: 99%

Positive Association between Altitude and Suicide in 2584 U.S. Counties

Brenner

Cheng

Clark

et al. 2011

High Altitude Medicine & Biology

115

View full text Add to dashboard Cite

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“…The study was performed as part of a medical research expedition to Mount Muztagh Ata (7546 m, China) [3,4,22]. The protocol was approved by the ethics committee of the Zurich University, subjects gave written informed consent, and the study is registered at ClinicalTrials.…”

Section: Subjects Measurements and Protocolmentioning

confidence: 99%

“…Prolonged stay at altitude was associated with an increase in PB. During PB episodes, higher peak power of ventilatory (MP VE ) and cardiac (MP LF HR ) oscillations and 1 3 exposed to hypobaric hypoxia [4,28]. It shares pathophysiologic aspects with the central sleep apnea syndrome and with Cheyne-Stokes respiration in patients with heart failure [5,10].…”

Section: Introductionmentioning

confidence: 99%

“…Related to differences in the feed-back control system (plant and controller gain, circulation time [20]) the cycle length of periodic breathing is shorter in healthy subjects exposed to hypobaric hypoxia (i.e., in the order of 15-25 s [4]), compared with patients with Cheyne-Stokes respiration due to heart failure (i.e., 25-100 s [6]). Ventilatory control instability causes changes in the cardiac autonomic regulation, which can be evaluated by analysis of heart rate variability (HRV) [35].…”

Section: Introductionmentioning

confidence: 99%

“…We analyzed data recorded in mountaineers participating in a medical research expedition to Mount Muztagh Ata, 7546 m, China [3,4,23]. Ventilation was continuously recorded through unobtrusive chest wall recordings using portable inductive plethysmography while mountaineers climbed from very high to extreme altitude [13] (from 4497 m up to 7546 m, Fig.…”

Section: Introductionmentioning

confidence: 99%

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Time-varying signal analysis to detect high-altitude periodic breathing in climbers ascending to extreme altitude

Garde

Giraldo

Jané

et al. 2015

Med Biol Eng Comput

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Effect of Nocturnal Oxygen Therapy on Nocturnal Hypoxemia and Sleep Apnea Among Patients With Chronic Obstructive Pulmonary Disease Traveling to 2048 Meters

et al. 2020

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IMPORTANCE There are no established measures to prevent nocturnal breathing disturbances and other altitude-related adverse health effects (ARAHEs) among lowlanders with chronic obstructive pulmonary disease (COPD) traveling to high altitude. OBJECTIVE To evaluate whether nocturnal oxygen therapy (NOT) prevents nocturnal hypoxemia and breathing disturbances during the first night of a stay at 2048 m and reduces the incidence of ARAHEs. DESIGN, SETTING, AND PARTICIPANTS This randomized, placebo-controlled crossover trial was performed from January to October 2014 with 32 patients with COPD living below 800 m with forced expiratory volume in the first second of expiration (FEV 1) between 30% and 80% predicted, pulse oximetry of at least 92%, not requiring oxygen therapy, and without history of sleep apnea. Evaluations were performed at the University Hospital Zurich (490 m, baseline) and during 2 stays of 2 days and nights each in a Swiss Alpine hotel at 2048 m while NOT or placebo treatment was administered in a randomized order. Between altitude sojourns, patients spent at least 2 weeks

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Nocturnal Periodic Breathing during Acclimatization at Very High Altitude at Mount Muztagh Ata (7,546 m)

Cited by 110 publications

References 31 publications

Positive Association between Altitude and Suicide in 2584 U.S. Counties

Positive Association between Altitude and Suicide in 2584 U.S. Counties

Time-varying signal analysis to detect high-altitude periodic breathing in climbers ascending to extreme altitude

Effect of Nocturnal Oxygen Therapy on Nocturnal Hypoxemia and Sleep Apnea Among Patients With Chronic Obstructive Pulmonary Disease Traveling to 2048 Meters

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