Nocturnal voiding frequency does not describe nocturia‐related bother

Rose, Georgie E; Denys, Marie‐Astrid; Kumps, Candy; Khan, Fary; Everaert, Karel; Bower, Wendy

doi:10.1002/nau.24029

Cited by 9 publications

(8 citation statements)

References 24 publications

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“…This finding is of utmost importance as this bother not only reflects the problem of getting up during the night, but also refers to the general quality of life and well-being of the patient. 30,31 Previously, it has been found that nighttime LUTS were more bothersome than daytime LUTS, 32 which can be explained by compromised sleep. 32,33 The decrease in nocturnal frequency and the improvement of bother can mostly likely be explained by the positive impact of HT on sleep, as the SLEEP sum score decreased significantly after treatment with both E þ P and TSEC.…”

Section: Discussionmentioning

confidence: 99%

Hormone therapy as a possible solution for postmenopausal women with nocturia: results of a pilot trial

et al. 2021

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Objective: To observe the impact of different hormonal treatment options on nocturia, its causative factors and bother in postmenopausal women. Methods: This prospective study recruited 245 postmenopausal women and divided them into four treatment groups based on patient's choice: Estrogen + Progesterone (E+P), Estrogen-only in patients with a prior hysterectomy, tissue-selective estrogen complex (TSEC) and no treatment. Nocturia and its causative factors were observed using two standardized questionnaires before and after treatment: the International Consultation on Incontinence Questionnaire Nocturia Module and the Targeting the individual's Aetiology of Nocturia to Guide Outcomes (TANGO). The results of the Targeting the individual's Aetiology of Nocturia to Guide Outcomes were divided in four influencing topics of which the sum score was calculated. Results: A significant reduction in prevalence of nocturia ≥ twice per night was seen after treatment, as the prevalence decreased from 27.7% (59/213) to 16.4% (35/213). Specified per therapy, a significant reduction in nocturnal voiding frequency was observed in patients treated with E+P and TSEC (P = 0.018 and P = 0.018, respectively). This improvement could be explained by a significant reduction in SLEEP sum score in patients treated with E+P and TSEC (P < 0.001, P = 0.013, respectively). Estrogen-only led to a significant change in URINARY TRACT sum score, which is the result of a reduction in urgency prevalence (P = 0.039). Conclusions: E+P and TSEC treatment led to a significant reduction in nocturia prevalence and bother in women with ≥ 2 nocturnal voids. This effect is mainly the result of improvement in sleep disorders, however an improvement in bladder disorders can be suggested as well. More research is necessary to confirm these findings. Video Summary: http://links.lww.com/MENO/A710.

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Section: Discussionmentioning

confidence: 99%

Hormone therapy as a possible solution for postmenopausal women with nocturia: results of a pilot trial

et al. 2021

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“…Although the International Continence Society defines nocturia as one or more voids during the main sleep period, for this study the clinically relevant definition of at least two voids per night was applied and referred to throughout the text as ‘disruptive nocturia’ 10 . Nocturia frequency was collected in two ways: as an open‐ended question (self‐report) and by derivation of the number of episodes on a bladder diary (actual nightly voids).…”

Section: Methodsmentioning

confidence: 99%

The association between nocturia, hormonal symptoms and bladder parameters in women: an observational study

Bower

Rose

Whishaw

et al. 2021

BJOG

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Objective Postmenopausal nocturia is poorly understood. This study aimed to identify hormonal and lifestyle factors associated with nocturia and to understand the relative contribution of altered urine production and bladder storage dysfunction in women. Design, setting, population and methods Women ≥40 years presenting to public continence services were enrolled in a cross‐sectional study. A total of 153 participants completed a hormone status questionnaire, a validated nocturia causality screening tool and a 3‐day bladder diary. Descriptive statistics and logistic regression models for nocturia severity and bladder diary parameters were computed. Results Overall, 91.5% reported nocturia, 55% ≥2 /night. There was a difference of 167.5 ml (P < 0.001) in nocturnal urine volume between women with nocturia ≥2 (median 736 ml) versus less often (517 ml). Significant predictors of self‐reported disruptive nocturia were age (odds ratio [OR] 1.04, 95% CI 1.002–1.073) and vitamin D supplementation (OR 2.33, 95% CI 1.11–4.91). Nocturnal polyuria was significantly more common with nocturia ≥2 compared with less frequent nocturia (P < 0.002). Exercise for 150 minutes a week was protective for nocturnal polyuria (OR 0.22, P = 0.001). Nocturia index >1.3 was significantly predicted by age (OR 1.07, P < 0.001), regular exercise (OR 0.41, P = 0.036), day flushes (OR 4.00, P = 0.013) and use of vitamin D (OR 2.34, P = 0.043). Maximum voided volumes were significantly lower with nocturia ≥2 versus less often (night: 268 ml versus 350 ml; day: 200 ml versus 290 ml). Conclusions Bothersome nocturia in postmenopausal women is associated with changes to both nocturnal diuresis and bladder storage. Regular physical activity, prolapse reduction and oestrogen replacement may be adjunctive in managing bothersome nocturia in women.

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“…More voids per night are also significantly associated with greater impact on both physical and mental health components of quality of life scores 2 . The following aspects of sleep have been reported significantly more often by individuals who void twice or more each night compared with those who do not: restless sleep, first undisturbed sleep time (FUST) less than 3 hours, difficulty falling back to sleep after voiding, insufficient overall sleep, low energy or fatigue during the day and worry that nocturia will get worse 3,4 . This severity of nocturia of at least twice at night has also been demonstrated to be significantly associated with more adverse health outcomes than less frequent night voiding.…”

Section: Disclosure Of Interestsmentioning

confidence: 99%