Nod-like receptor protein 3 and nod-like receptor protein 1 inflammasome activation in the hippocampal region of postmortem methamphetamine chronic user

Mahmoudiasl, Gholam-Reza; Abbaszadeh, Hojjat-Allah; Rezaei‐Tavirani, Mostafa; Abdollahifar, Mohammad‐Amin; Khoramgah, Maryam Sadat; Niknazar, Somayeh; Darabi, Shahram; Roozbahany, Navid Ahmady

doi:10.4149/bll_2019_129

Cited by 14 publications

(14 citation statements)

References 35 publications

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“…Neuroinflammation is a major underlying mechanism of methamphetamine (METH)-induced cognitive deficits. Increased levels of hippocampal NLRP1 and NLRP3 inflammasome expression as well as the induction of inflammation and apoptosis were found in 11 patients with METH drug use disorder [ 110 ]. METH promotes NLRP inflammasome release, and upregulates caspase-1 expressions, causing the aggregation of apoptosis-associated ASC proteins from rat cortical microglial.…”

Section: Roles Of Nlrp Inflammasome In Neuropsychiatric Disordersmentioning

confidence: 99%

The Significance of NLRP Inflammasome in Neuropsychiatric Disorders

et al. 2022

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The NLRP inflammasome is a multi-protein complex which mainly consists of the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain. Its activation is linked to microglial-mediated neuroinflammation and partial neuronal degeneration. Many neuropsychiatric illnesses have increased inflammatory responses as both a primary cause and a defining feature. The NLRP inflammasome inhibition delays the progression and alleviates the deteriorating effects of neuroinflammation on several neuropsychiatric disorders. Evidence on the central effects of the NLRP inflammasome potentially provides the scientific base of a promising drug target for the treatment of neuropsychiatric disorders. This review elucidates the classification, composition, and functions of the NLRP inflammasomes. It also explores the underlying mechanisms of NLRP inflammasome activation and its divergent role in neuropsychiatric disorders, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, depression, drug use disorders, and anxiety. Furthermore, we explore the treatment potential of the NLRP inflammasome inhibitors against these disorders.

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Section: Roles Of Nlrp Inflammasome In Neuropsychiatric Disordersmentioning

confidence: 99%

The Significance of NLRP Inflammasome in Neuropsychiatric Disorders

et al. 2022

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“…Consequently, "tolerance" to the ORF-1 mRNA-increasing effect of METH may be due to accelerated decrease in these RNAs. Chronic METH can induce apoptosis and cell death in the hippocampus [27,85]; therefore, it is also possible that ORF-1 mRNA decreased in this brain region, due to the accelerated death of cells containing ORF-1 mRNA during chronic treatment with METH.…”

Section: Discussionmentioning

confidence: 99%

Differential Responses of LINE-1 in the Dentate Gyrus, Striatum and Prefrontal Cortex to Chronic Neurotoxic Methamphetamine: A Study in Rat Brain

Moszczynska

2020

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Methamphetamine (METH) is a widely abused psychostimulant with the potential to cause a broad range of severe cognitive deficits as well as neurobehavioral abnormalities when abused chronically, particularly at high doses. Cognitive deficits are related to METH neurotoxicity in the striatum and hippocampus. The activation of transposable Long INterspersed Nuclear Element 1 (LINE-1) is associated with several neurological diseases and drug abuse, but there are very limited data regarding the effects of high-dose METH on the activity of LINE-1 in the adult brain. Using real-time quantitative PCR, the present study demonstrates that the chronic administration of neurotoxic METH doses results in the increased expression of LINE-1-encoded Open Reading Frame 1 (ORF-1) in rat striatum shortly after the last dose of the drug and decreased ORF-1 expression during METH withdrawal, with dentate gyrus potentially developing “tolerance” to these METH effects. LINE-1 activation may be a new factor mediating the neurotoxic effects of chronic METH in the striatum and, therefore, a new drug target against METH-induced psychomotor impairments in chronic METH users.

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“…Interestingly, emerging evidence has emphasized the combined roles of NLRP1 and NLRP3 in the CNS ( 147 , 148 ), especially in brain injury ( 24 , 146 , 149 ). Moreover, a report showed that high levels of NLRP1 and NLRP3 were present in the hippocampus of patients abusing methamphetamine ( 150 ), indicating the relationship between these two classic inflammasomes and a promising strategy for the treatment of brain injury.…”

Section: Nlrp1 As a Target For The Treatment Of Brain Injurymentioning

confidence: 99%

NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury

Min

Chai³

et al. 2022

Front. Immunol.

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NOD-like receptor (NLR) family pyrin domain-containing 1 (NLRP1) is a member of the NLR family. The NLRP1 inflammasome consists of the NLRP1 protein, the adaptor protein apoptosis-associated speck-like protein containing a CARD domain, and the effector molecule pro-caspase-1. When stimulated, the inflammasome initiates the cleavage of pro-caspase-1 and converts it into its active form, caspase-1; then, caspase-1 facilitates the cleavage of the proinflammatory cytokines interleukin-1β and interleukin-18 into their active and secreted forms. In addition, caspase-1 also mediates the cleavage of gasdermin D, which leads to pyroptosis, an inflammatory form of cell death. Pathological events that damage the brain and result in neuropathological conditions can generally be described as brain injury. Neuroinflammation, especially that driven by NLRP1, plays a considerable role in the pathophysiology of brain injury, such as early brain injury (EBI) of subarachnoid hemorrhage, ischemic brain injury during stroke, and traumatic brain injury (TBI). In this article, a thorough overview of NLRP1 is presented, including its structure, mechanism of activation, and role in neuroinflammation. We also present recent studies on NLRP1 as a target for the treatment of EBI, ischemic brain injury, TBI, and other types of brain injury, thus highlighting the perspective of NLRP1 as an effective mediator of catastrophic brain injury.

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Nod-like receptor protein 3 and nod-like receptor protein 1 inflammasome activation in the hippocampal region of postmortem methamphetamine chronic user

Cited by 14 publications

References 35 publications

The Significance of NLRP Inflammasome in Neuropsychiatric Disorders

The Significance of NLRP Inflammasome in Neuropsychiatric Disorders

Differential Responses of LINE-1 in the Dentate Gyrus, Striatum and Prefrontal Cortex to Chronic Neurotoxic Methamphetamine: A Study in Rat Brain

NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury

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