NOD Signaling and Cell Death

Heim, Valentin Johannes; Stafford, Che A.; Nachbur, Ueli

doi:10.3389/fcell.2019.00208

Cited by 77 publications

(56 citation statements)

References 168 publications

(229 reference statements)

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“…They monitor both inflammation and apoptosis signaling pathways. These receptors expressed in many cell types, including immune cells (lymphocytes, macrophages, dendritic cells) and even epithelial cells [61]. It is observed that activation of cytosolic NLRs increased during aging and in many age-related diseases such as type 2 diabetes mellitus.…”

Section: Aging and Autophagymentioning

confidence: 99%

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

et al. 2020

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Purpose Novel Coronavirus disease 2019 (COVID-19), is an acute respiratory distress syndrome (ARDS), which is emerged in Wuhan, and recently become worldwide pandemic. Strangely, ample evidences have been shown that the severity of COVID-19 infections varies widely from children (asymptomatic), adults (mild infection), as well as elderly adults (deadly critical). It has proven that COVID-19 infection in some elderly critical adults leads to a cytokine storm, which is characterized by severe systemic elevation of several pro-inflammatory cytokines. Then, a cytokine storm can induce edematous, ARDS, pneumonia, as well as multiple organ failure in aged patients. It is far from clear till now why cytokine storm induces in only COVID-19 elderly patients, and not in young patients. However, it seems that aging is associated with mild elevated levels of local and systemic pro-inflammatory cytokines, which is characterized by "inflamm-aging". It is highly likely that "inflamm-aging" is correlated to increased risk of a cytokine storm in some critical elderly patients with COVID-19 infection. Methods A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, as well as Google Scholar pre-print database using all available MeSH terms for COVID-19, Coronavirus, SARS-CoV-2, senescent cell, cytokine storm, inflame-aging, ACE2 receptor, autophagy, and Vitamin D. Electronic database searches combined and duplicates were removed. Results The aim of the present review was to summarize experimental data and clinical observations that linked the pathophysiology mechanisms of "inflamm-aging", mild-grade inflammation, and cytokine storm in some elderly adults with severe COVID-19 infection.

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Section: Aging and Autophagymentioning

confidence: 99%

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

et al. 2020

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“…In addition to innate immune response, NOD1 is also involved in the activation of the apoptosis signaling pathway through its interaction with the CARD domain of RIP2. RIP2 is considered to be an important component of the multiprotein signaling complex that mediates innate immune responses induced by the activation of NOD1 [29,30]. The abnormal expression of NOD1 and RIP2 has been associated with cell apoptosis and development of breast cancer and oral cancer [18,31].…”

Section: Discussionmentioning

confidence: 99%

HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer

Liu

Fei

et al. 2020

Infect Agents Cancer

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Cervical cancer is the fourth most common malignant tumor in women worldwide. The persistent infection of high-risk Human Papillomavirus (hrHPV) is considered to be the primary cause of this disease. As an innate immune receptor, the nucleotide-binding oligomerization domain protein-1 (NOD1) recognizes the pathogen-associated molecular pattern (PAMP), subsequently initiating immune responses. NOD1 is also involved in the apoptotic signaling pathway and mutates in many cancer cells. In the study, we revealed that NOD1 expression decreased during the progression of cervical intraepithelial neoplasia to cervical cancer and that HPV16 E6/E7 oncoproteins induced down-regulation of NOD1. Moreover, the activation of NOD1 promoted the apoptosis of HPV16-positive cervical cancer cells. The data indicated that the dysregulation of NOD1-mediated inflammation and apoptosis may contribute to cervical intraepithelial neoplasia progression and cervical cancer.

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“…sarcoidosis, rheumatoid arthritis, solid cancers, uveitis, neuropathic pain, and type 2 diabetes mellitus [6].…”

Section: Case Reportmentioning

confidence: 99%

Gullo’s Syndrome – case report

Rycyk¹,

Furtak²,

Mądro³

et al. 2020

J Pre Clin Clin Res.

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Benign pancreatic hyperenzymemia (BPH) or Gullo's Syndrome is a persistent elevation of pancreatic enzymes activity, observed for at least one year, with no pancreatic disorder. This diagnosis is extremely important because it allows us to avoid many unnecessary examinations performed during the diagnostic process. The case is presented of a 25-year-old man who was examined for recurrent elevated lipase and amylase serum values over a time period of 2 years who presented with non-specific abdominal complaints. Interestingly, his routine tests showed sustained elevated serum amylase and lipase activity. He was intensively diagnosed due to pancreatic hyperenzymemia, but no pancreatic disease was detected. The observation lasted two years. The serum lipase and serum amylase levels continued to increase after that time. This diagnosis requires attention because BPH can be the first symptom of pancreatic cancer.

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NOD Signaling and Cell Death

Cited by 77 publications

References 168 publications

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

HPV-mediated down-regulation of NOD1 inhibits apoptosis in cervical cancer

Gullo’s Syndrome – case report

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