2014
DOI: 10.1016/j.clinre.2014.02.003
|View full text |Cite
|
Sign up to set email alerts
|

NOD2/CARD15 and IL23R genetic variability in 204 Algerian Crohn's disease

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
11
0

Year Published

2015
2015
2018
2018

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 12 publications
(11 citation statements)
references
References 32 publications
0
11
0
Order By: Relevance
“…A total of 33 articles, 20,23,24,[27][28][29][30][31]33,35,37,38,[40][41][42]44,47,[48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] involving 8110 cases and 11,900 controls (Table 2), were included to the meta-analysis regarding the genetic effect of the The overall genetic risk suggested significant protection for the AA genotype (OR G ¼ 0.46; 95% CI, 0.41-0.52). The subgroup analysis on adults 16 20,23,24,[27][28][29][30]33,35,37,38,41,[47][48][49][50]…”
Section: Il23r Variant Rs11209026 and Disease Susceptibilitymentioning
confidence: 99%
See 1 more Smart Citation
“…A total of 33 articles, 20,23,24,[27][28][29][30][31]33,35,37,38,[40][41][42]44,47,[48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] involving 8110 cases and 11,900 controls (Table 2), were included to the meta-analysis regarding the genetic effect of the The overall genetic risk suggested significant protection for the AA genotype (OR G ¼ 0.46; 95% CI, 0.41-0.52). The subgroup analysis on adults 16 20,23,24,[27][28][29][30]33,35,37,38,41,[47][48][49][50]…”
Section: Il23r Variant Rs11209026 and Disease Susceptibilitymentioning
confidence: 99%
“…Nine control populations deviated from HWE equilibrium, 42,44,[50][51][52]54,56,57,59 and the combined effects were recalculated after genotype correction with their expected distribution. These effects did not change after correcting for HWE deviations, and they appear in brackets in Table 3.…”
Section: Il23r Variant Rs11209026 and Disease Susceptibilitymentioning
confidence: 99%
“…One of the most important components of the IL23/IL23R pathway, namely IL23R, has been shown to form a predisposition for both UC and CD (6,9,32). In IBD patients, the IL23 serum levels are increased, while in IL23R knockout mice, the IBD symptoms have been observed to regress (24,28 (18,32,33). This variant is associated with late onset CD and appears to be protective against CD with ileocolonic involvement (33).…”
Section: Discussionmentioning
confidence: 99%
“…It is thought that the IL23/IL23R signal pathway may play a central role in the pathogenesis of IBD. Though there are studies showing that IL23R, JAK2, and STAT3 cause susceptibility to UC and CD in different ethnic groups, the results are not consistent (6,13,(15)(16)(17)(18)(19)(20)(21). The reason for this discrepancy may be that IBD in different ethnic communities may appear through different predominant mechanisms.…”
Section: Introductionmentioning
confidence: 98%
“…For the meta-analysis of R702W, L1007fs and G908R, we included data from 89, 90 and 96 published articles(for R702W, G908 and L1007fs, respectively) with a combined total of 23,703 cases and 22,873 controls, which were published before December 31 st , 2016(D’Addabbo et al 2009; Schoultz et al 2009; Yazdanyar et al 2009; Csöngei et al 2010; Dassopoulos et al 2010; Gazouli et al 2010; Glas et al 2010; Hoffmann et al 2010; Lacher et al 2010; Sventoraityte et al 2010; Yazdanyar et al 2010; Naderi et al 2011; Adeyanju et al 2012; Azzam et al 2012; Hama et al 2012; Kanaan et al 2012; Akyuz et al 2013; Meddour et al 2014; Boukercha et al 2015; Salkic et al 2015), and conducted the analysis in R using the ‘meta’ package. We calculated the odds ratios for the three variants in the meta-analysis using DerSimonian-Laird statistics as a random-effects model.…”
Section: Methodsmentioning
confidence: 99%