Nodal FDG-PET/CT uptake influences outcome and relapse location among esophageal cancer patients submitted to chemotherapy or radiochemotherapy

Jimenez-Jimenez, E.; Mateos, P.; Ortiz, Irene; Aymar, N.; Roncero, R.; Gimenez, Marta; Pardo, J.; Sabater, S.

doi:10.1007/s12094-019-02038-6

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…Previous studies have discussed the value of PET for predicting the outcomes of oesophageal cancer (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Some studies highlighted ΔSUVmax (pre-treatment PET SUVmax -post-treatment PET SUVmax) as a predictor of tumour response, pathology grade, and outcome for patients who receive tri-modality treatment (7).…”

Section: Discussionmentioning

confidence: 99%

“…Oesophageal cancer is the seventh most common cancer and sixth most common cause of cancerrelated deaths (1). Concurrent chemoradiotherapy (CCRT) has become the standard treatment for locally advanced disease (2), and surgery has been shown to improve survival in some patients (3). However, several studies have reported a signi cant proportion of disease recurrence after surgery (4).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have demonstrated the value of positron emission tomography (PET) in predicting the outcomes of oesophageal cancer (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Hamai et al published a study on the correlation between the maximum standardised uptake value (SUVmax) after neoadjuvant chemoradiotherapy (NCRT) and tumour histology grading.…”

Section: Introductionmentioning

confidence: 99%

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Maximum standardised uptake value of positron emission tomography as a predictor of oesophageal cancer outcomes

Lai,

Ho,

et al. 2024

Preprint

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Objectives This study aimed to analyse the value of pre-operative 18F-fluorodeoxyglucose positron emission tomography (PET)-computed tomography that can predict tumour pathological complete response, tumour histology grade, overall survival, and recurrence-free survival in patients with locally advanced oesophageal squamous cell carcinoma who underwent concurrent chemoradiotherapy (CCRT) followed by surgery. Methods We retrospectively reviewed the cases of patients with locally advanced oesophageal squamous cell carcinoma undergoing CCRT followed by surgery. Patients who did not undergo PET within 3 months of surgery were excluded. We set a pre-operative PET maximum standardised uptake value (SUVmax) of > 5 as the threshold and classified the patients into two groups. We analysed the tumour response and histology grade, and compared the overall survival and recurrence-free survival between the two groups. Results This cohort included 92 patients with oesophageal squamous cell carcinoma who underwent CCRT followed by surgery; 49 patients had a pre-operative PET SUVmax < 5, and 43 patients had a pre-operative PET SUVmax > 5. The patients’ pre-operative PET SUVmax correlated with tumour histology, ypT stage, and tumour response. Patients with a pre-operative SUVmax < 5 had better 2-year-overall survival (78% vs. 62%, P < 0.05) and 2-year recurrence-free survival (62% vs. 34%, P < 0.05) than those with a pre-operative SUV > 5. Conclusions Pre-operative SUVmax may be useful to predict tumour response, survival, and recurrence in patients with locally advanced oesophageal squamous cell carcinoma who undergo CCRT followed by surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maximum standardised uptake value of positron emission tomography as a predictor of oesophageal cancer outcomes

Lai,

Ho,

et al. 2024

Preprint

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“…Previous studies on the extent of lymph node metastasis in esophageal cancer have shown that patients can be risk stratified according to the number of metastatic fields confirmed after surgery [ 39 , 40 ], and the more metastatic fields, the shorter survival. In addition, Jimenez-Jimenez et al [ 41 ] analyzed 56 patients with esophageal cancer and observed that if the involved lymph nodes were closer to the primary tumor, the survival rate of patients would be higher. Ielpo et al [ 42 ] studied 64 postoperative patients with adenocarcinoma at the esophagogastric junction, and divided lymph nodes into proximal lymph node group (including cardia, lesser and large curvature and left gastric artery) and distal lymph node group (including lymph nodes from the celiac axis, common hepatic artery, lower mediastinum and tracheal bifurcation.).…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of baseline 18F-FDG PET/CT in patients with esophageal squamous cell carcinoma treated with definitive (chemo)radiotherapy

Xia

Zhu

et al. 2023

Radiat Oncol

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Purpose To investigate the prognostic value of baseline 18F-FDG PET/CT in patients with esophageal squamous cell carcinoma (ESCC) treated with definitive (chemo)radiotherapy. Methods A total of 98 ESCC patients with cTNM stage T1-4, N1-3, M0 who received definitive (chemo)radiotherapy after 18F-FDG PET/CT examination from December 2013 to December 2020 were retrospectively analyzed. Clinical factors included age, sex, histologic differentiation grade, tumor location, clinical stage, and treatment strategies. Parameters obtained by 18F-FDG PET/CT included SUVmax of primary tumor (SUVTumor), metabolic tumor volume (MTV), total lesion glycolysis (TLG), SUVmax of lymph node (SUVLN), PET positive lymph nodes (PLNS) number, the shortest distance between the farthest PET positive lymph node and the primary tumor in three-dimensional space after the standardization of the patient BSA (SDmax(LN-T)). Univariate and multivariate analysis was conducted by Cox proportional hazard model to explore the significant factors affecting overall survival (OS) and progression-free survival (PFS) in ESCC patients. Results Univariate analysis showed that tumor location, SUVTumor, MTV, TLG, PLNS number, SDmax (LN-T) were significant predictors of OS and tumor location, and clinical T stage, SUVTumor, MTV, TLG, SDmax (LN-T) were significant predictors of PFS (all p < 0.1). Multivariate analysis showed that MTV and SDmax (LN-T) were independent prognostic factors for OS (HR = 1.018, 95% CI 1.006–1.031; p = 0.005; HR = 6.988, 95% CI 2.119–23.042; p = 0.001) and PFS (HR = 1.019, 95% CI 1.005–1.034; p = 0.009; HR = 5.819, 95% CI 1.921–17.628; p = 0.002). Combined with independent prognostic factors MTV and SDmax (LN-T), we can further stratify patient risk. Conclusions Before treatment, 18F-FDG PET/CT has important prognostic value for patients with ESCC treated with definitive (chemo)radiotherapy. The lower the value of MTV and SDmax (LN-T), the better the prognosis of patients.

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“…Image analysis procedures have already been described [14]. The PET images were evaluated qualitatively (visual inspection) and semiquantitatively (SUVs).…”

Section: Image Interpretation and Analysismentioning

confidence: 99%

Percentage Change on FDG-PET/CT Predicts Complete Response to Neoadjuvant Radiochemotherapy in Esophageal Cancer

Jimenez-Jimenez¹,

Ortiz²,

Aymar³

et al. 2019

IJCM

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Objective: We evaluated whether the changes in FDG-PET/CT uptake between pre/and post-treatment might predict a complete response in esophageal cancer (EC). Patients and Methods: Fifty-six patients with 2 PET-CTs studies were evaluated retrospectively. Images were evaluated qualitatively and semiquantitatively (SUVs). Patients were classified as persistence of disease, complete metabolic response and unspecific FDG uptake. The SUVmax values and percentages of change in SUV were measured. Results: A significant difference was found between the persistence group and the non-persistence group regarding the median percentage change in SUVtumor (72.95% vs. 54.12%; p = 0.04) and regarding the percentage change in SUVnode (89.91% vs. 59.91%, p = 0.04). In patients treated with radiochemotherapy (RCTX), a significant difference was found between the persistence group and the no persistence group regarding the percentage change in SUVtumor (58.02% vs. 78.59%). Overall survival rate was related to the percentage of change in the SUVtumor. The group of ≥75% of change SUVtumor showed a median survival of 37.32 months (IC: 95% = 49.93-24.70) and the group of <75% of change SUVtumor showed a median survival of 18.39 months (IC: 95% = 25.14-11.65) (p = 0.04). In patients with metastatic relapse, a significant difference was found regarding the percentage change in SUVnode (94.63% vs. 74.09%). Conclusion: Our study provides evidence that the percentage change in the SUVmax is a predictor of the response to neoadjuvant treatment in patients with EC.

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Nodal FDG-PET/CT uptake influences outcome and relapse location among esophageal cancer patients submitted to chemotherapy or radiochemotherapy

Cited by 6 publications

References 24 publications

Maximum standardised uptake value of positron emission tomography as a predictor of oesophageal cancer outcomes

Maximum standardised uptake value of positron emission tomography as a predictor of oesophageal cancer outcomes

Prognostic value of baseline 18F-FDG PET/CT in patients with esophageal squamous cell carcinoma treated with definitive (chemo)radiotherapy

Percentage Change on FDG-PET/CT Predicts Complete Response to Neoadjuvant Radiochemotherapy in Esophageal Cancer

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