Nodal Melanocytic Nevi in Sentinel Lymph Nodes

Abstract

Melanocytic nevi occurring in lymph nodes create diagnostic difficulty by mimicking metastases. Few studies describe nodal nevi in sentinel lymph nodes (SLNs) excised for melanoma. We evaluated 72 cases in which patients had undergone SLN biopsy for melanoma. Lymph nodes and cutaneous melanomas were evaluated according to a standard protocol. Nodal nevi were identified in 8 patients (11%). Of these, 6 (75%) had an associated cutaneous nevus (P = .006). Of 21 patients with an associated nevus, 4 (19%) with nodal nevi had a cutaneous nevus with congenital features (P = .01). The incidence of nodal nevus correlated with a Breslow thickness greater than 2.5 mm (P = .02). Nevi were not seen in non-SLNs. Nodal nevi appear more frequently in patients with melanoma-associated cutaneous nevi, particularly if congenital features are present. The increased frequency of nodal nevi in SLNs relative to non-SLNs suggests an etiology of mechanical transport of nevus cells.

Futility of Fluorodeoxyglucose F 18 Positron Emission Tomography in Initial Evaluation of Patients With T2 to T4 Melanoma

“…However, when cytologically compared with the primary melanoma, these nevi are bland nevocellular ag- gregates that do not resemble melanoma. 7 A PubMed database search revealed no reported cases of increased fluorodeoxyglucose F 18 uptake in nodal nevi. Sentinel lymph node dissection confirmed the 2 true-positive PET findings, both in sentinel lymph nodes that were grossly positive at surgery.…”

Completely regressed primary cutaneous malignant melanoma with nodal and/or visceral metastases: A report of 5 cases and assessment of the literature and diagnostic criteria

“…Still others have observed rests of nevus cells within nodal tissue. 74,75 It is also possible that such cases represent malignant degeneration of pre-existing rests of nevus cells within lymph nodes, although this remains purely speculative. 3 Of concern to us are cases that lie outside the current criteria, which have developed within the literature.…”

Antimicrobial and Antiquorum‐Sensing Studies. Part 3: Synthesis and Biological Evaluation of New Series of [1,3,4]Thiadiazoles and Fused [1,3,4]Thiadiazoles

“…Also, these compounds were tested for their antifungal activity against Candida albicans and Aspergillus flavus 3375 applying the agar diffusion method [52]. The antifungal screening results were determined by measuring the average diameter of the inhibition zones, expressed in millimeters.…”

“…Antimicrobial and antiquorum-sensing activities Compounds 3a-d, 4, 5a-c, 6a-c, 7a-c, 10a,b, 12a,b, and 15a-c were screened for their antibacterial activity against S. aureus, B. cereus, and E. coli in Luria-Bertani (LB) agar medium [50]. The same compounds were also screened for their antifungal activity against C. albicans in Sabouraud's agar medium and A. flavus 3375 in glucose minimal medium [50,52]. In addition, their antipathogenic potential was checked by examining the antiquorum-sensing activity against Ch.…”

“…In addition, DMSO (control solvent) was added to each plate. Plates were incubated at 37°C for 48 h for C. albicans and at 30°C for 48 h for A. flavus 3375 [52]. The antifungal activity of the tested compounds was determined by measuring the diameter of the inhibition zones ( Table 2).…”