Nodal Metastasis in Non–Small Cell Lung Cancer: Accuracy of 3.0-T MR Imaging

Kim, Ha Young; Yi, Chin A; Lee, Kyung Soo; Chung, Myung Jin; Kim, Yoon Kyung; Choi, Bong Keun; Kim, Hojoong; Kwon, O Jung

doi:10.1148/radiol.2461061907

Cited by 28 publications

(19 citation statements)

References 37 publications

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“…However, this sizebased characterization of lymph node metastasis frequently leads to misdiagnosis as metastatic lymph nodes may be of normal size, whereas nonmetastatic lymph nodes may become abnormally enlarged due to reactive swelling (defined pathologically as reactive lymphadenopathy; ref. 9). Recently, Zhang and colleagues (10) have reported that both diffusion-weighted and superparamagnetic iron oxide-enhanced MRI can distinguish tumor metastatic lymph nodes from reactive lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Sonographic Imaging to Diagnose Lymph Node Metastasis: Importance of Blood Vessel Volume and Density

Mori

Kodama

et al. 2013

Cancer Research

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Lymph node size is an important variable in ultrasound diagnosis of lymph node metastasis. However, the size criterion often leads to oversight of tumor-positive lymph nodes within the range of "normal" size, such that more accurate diagnostic criteria for lymph node metastasis are required. In this study, we show how diagnosis of lymph node metastasis can be improved by evaluating changes in blood vessel volume and density using a novel contrast-enhanced high-frequency ultrasound (CE-HFUS) system with Sonazoid. An MRL/MpJ-lpr/lpr (MRL/lpr) mouse model of lymph node metastasis was used in which lymph nodes are similar in size to humans. Metastasis via lymphatic vessels to proper axillary lymph nodes (proper ALN) was induced by injection of tumor cells into the subiliac lymph nodes. Within 21 days of injection, significant increases in blood vessel volume and density, but no increases in the size of the proper ALNs, were observed. The increase in blood vessel density was confirmed with immunohistochemical analysis and was positively related to tumor cell proliferation as measured using bioluminescence imaging. Together, our results showed that alterations in blood vessel volume and density precede alterations in lymph node size in the early stages of lymph node metastasis. Detection of these changes by ultrasonography may offer new criteria for early diagnosis of lymph node metastasis. Cancer Res; 73(7); 2082-92. Ó2013 AACR.

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Section: Introductionmentioning

confidence: 99%

Enhanced Sonographic Imaging to Diagnose Lymph Node Metastasis: Importance of Blood Vessel Volume and Density

Mori

Kodama

et al. 2013

Cancer Research

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“…Eccentric cortical thickening and obliteration of the fatty hilum are features suggestive of a malignant node. 48 Conventional CT has a low sensitivity of 41%-68% and a specificity of 43%-97% in the detection of mediastinal nodal metastasis. 48,49 With MRI, the SI of malignant lymph nodes is higher than that of benign ones on T1W and T2W sequences.…”

Section: Staging Of Lung Cancermentioning

confidence: 99%

PET/MRI in Lung Cancer

Fan

Sher

Kohan

et al. 2014

Seminars in Roentgenology

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“…First, T2-weighted imaging played a role in screening for presumed metastatic lymph nodes and in facilitating anatomical correlation with the PET/CT. The nodes satisfying both high signal intensity and malignant morphological features on T2-weighted imaging were considered metastatic lymph nodes [18]. Second, malignant-looking nodes on T2-weighted imaging were evaluated on DWI.…”

Section: Combined Mri and Pet/ctmentioning

confidence: 99%

“…Some recent studies have reported that various magnetic resonance imaging (MRI) techniques can be useful for detecting and excluding nodal metastasis [15][16][17][18][19]. On T2-weighted triple-inversion black-blood fast spin-echo MRI, the morphological details of lymph nodes appear to be important for detecting nodal metastasis with high specificity and accuracy [18].…”

Section: Introductionmentioning

confidence: 99%

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A proposal for combined MRI and PET/CT interpretation criteria for preoperative nodal staging in non-small-cell lung cancer

Kim

Lee

et al. 2012

Eur Radiol

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Inclusive criteria in combined MRI and PET/CT readings help improve significantly the sensitivity for detecting nodal metastasis compared with PET/CT alone and may decrease unnecessary open thoracotomy. Key Points • Combined interpretation of MRI and PET/CT enhances the detection of nodal metastasis. • Inclusive criteria of combined MRI/PET/CT improved the sensitivity for detecting nodal metastasis. • Combined interpretation of MRI and PET/CT may reduce unnecessary open thoracotomies.

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Nodal Metastasis in Non–Small Cell Lung Cancer: Accuracy of 3.0-T MR Imaging

Abstract: Morphologic details of lymph nodes on T2-weighted triple-inversion black-blood fast spin-echo MR images are significant for detection of mediastinal or hilar nodal metastasis at 3.0-T MR imaging.

Cited by 28 publications

References 37 publications

Enhanced Sonographic Imaging to Diagnose Lymph Node Metastasis: Importance of Blood Vessel Volume and Density

Enhanced Sonographic Imaging to Diagnose Lymph Node Metastasis: Importance of Blood Vessel Volume and Density

PET/MRI in Lung Cancer

A proposal for combined MRI and PET/CT interpretation criteria for preoperative nodal staging in non-small-cell lung cancer

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