2021
DOI: 10.1016/j.jbc.2021.100937
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Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology

Abstract: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, a… Show more

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Cited by 9 publications
(6 citation statements)
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“…Despite its abundance in the isolate, NOMO was not modelled into the single particle analysis reconstruction, presumably because the resolution of ER luminal densities was affected by flexibility ( McGilvray et al, 2020 ). Negative stain electron microscopy and sequence analysis of NOMO suggest an elongated shape, comprising 12 immunoglobulin (Ig)-like domains that are arranged like “beads on a string” ( Amaya et al, 2021 ). AlphaFold models of NOMO paralogs are consistent with this notion ( Jumper et al, 2021 ; Varadi et al, 2022 ).…”
Section: Resultsmentioning
confidence: 99%
“…Despite its abundance in the isolate, NOMO was not modelled into the single particle analysis reconstruction, presumably because the resolution of ER luminal densities was affected by flexibility ( McGilvray et al, 2020 ). Negative stain electron microscopy and sequence analysis of NOMO suggest an elongated shape, comprising 12 immunoglobulin (Ig)-like domains that are arranged like “beads on a string” ( Amaya et al, 2021 ). AlphaFold models of NOMO paralogs are consistent with this notion ( Jumper et al, 2021 ; Varadi et al, 2022 ).…”
Section: Resultsmentioning
confidence: 99%
“…Despite its abundance in the isolate, NOMO was not modelled into the SPA reconstruction, presumably because the resolution of ER luminal densities was affected by flexibility 19 . Negative stain electron microscopy and sequence analysis of NOMO suggest an elongated shape, comprising 12 immunoglobulin (Ig)-like domains that are arranged like ‘beads on a string’ 36,37 . AlphaFold models of NOMO paralogs are consistent with this notion 37,38 .…”
Section: Resultsmentioning
confidence: 99%
“…The prior BOS model omitted NOMO, so to fully characterise this clash we ran a prediction of the full BOS complex structure, obtaining a high-confidence prediction that fits a previously reported subtomogram average 7 (Figure 6B). As an aside, it is noteworthy that the first pre-albumin-like domain (PLD1) in NOMO is predicted to bind PLD10 and PLD11, suggesting that its reported ability to regulate the spacing between ER sheets 102 results from it forming antiparallel homodimers across the ER lumen (Figure 6–figure supplement 1B). Contemporaneous work 41 has arrived at a similar model for PLD10-12 but did not model PLD1.…”
Section: Resultsmentioning
confidence: 99%