Nodular Fasciitis: A Clinicopathologic Analysis of 65 Cases

Price, Edward B.; Silliphant, William M.; Shuman, Richard

doi:10.1093/ajcp/35.2.122

Cited by 242 publications

(79 citation statements)

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“…The lesion in our case was markedly hypoechoic on the gray-scale images, and marked, prominent vascularity was noted within the mass on the color Doppler images. The differences in the echogenicity and color signals on US may reflect the subtypes of NF (i.e., the myxoid, cellular and fibrous types) and the variable vascularity contained in the individual lesions (9). The NECT and CECT findings of NF in our case were similar to those of previous reports in that there was a well demarcated lobular isoattenuating mass on NECT with strong, but slightly inhomogeneous enhancement on CECT.…”

Section: Discussionsupporting

confidence: 80%

Nodular Fasciitis of the Face Diagnosed by US-Guided Core Needle Biopsy: A Case Report

Lee

Kwon

2006

J Korean Radiol Soc

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Nodular fasciitis (NF) is a benign, reactive, tumor-like proliferation of myofibroblasts that appears as a rapidly growing solitary mass. The most common locations are the extremities; this is followed by trunk, head and neck in decreasing order. A literature search yielded only a few reports concerning the imaging findings of NF (1 5). Most of those reports are focused on the computed tomographic (CT) and magnetic resonance (MR) imaging findings of NF in the extremities and the neck. Ultrasonography (US) is the usual initial diagnostic modality for evaluating a palpable mass in the face. Thus, knowledge of the gray-scale and color Doppler US findings of NF is prerequisite for radiologists. A few reports (6 8) have stressed the role of the fine needle aspiration cytology (FNAC) in the cytologic diagnosis of NF in the extremities, breast and face, but the role of USguided core needle biopsy (CNB) in the histologic diagnosis of NF has not been discussed.We report here on a case of NF of the face along with gray-scale and color Doppler US and CT findings, and we report on the role of US-guided CNB for the histologic diagnosis of NF of the face. Case ReportA 31-year-old man presented with a palpable mass at the right cheek that was noticed 1 month earlier. There was no history of previous trauma. On physical examination, a firm, nontender, mobile mass about 3 cm in size was found at the right cheek. US demonstrated an approximately 2.5 cm sized lobular markedly hypoechoic solid mass in the right cheek that probably arose from the perioral muscle and it was protruding into the subcutaneous fat (Figs. 1A, B). Prominent vascularity was noted within the mass on the color Doppler images (Fig. 1C). Non-enhanced computed tomography (NECT) revealed a well circumscribed mass that was isoattenuated compared to the adjacent muscles, and it was mainly in the subcutaneous layer. The axial contrast-enhanced CT (CECT), and coronal and sagittal reformatted CECT images demonstrated a well-demarcated solid We report here on a case of nodular fasciitis (NF) that was diagnosed by ultrasonography (US)-guided core needle biopsy in a 31-year-old man, and we include the US and computed tomographic (CT) findings and the histopathologic findings at US-guided core needle biopsy (CNB). We suggest that high-resolution US is useful for the detailed evaluation of NF in the superficial regions, such as the face, and US-guided CNB is useful for the definitive histologic diagnosis of NF without causing scarring.

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Section: Discussionsupporting

confidence: 80%

Nodular Fasciitis of the Face Diagnosed by US-Guided Core Needle Biopsy: A Case Report

Lee

Kwon

2006

J Korean Radiol Soc

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“…The intramuscular type is typically larger in size (Meyer et al, 1991) and can mimic a sarcoma (Batsakis and el-Naggar, 1994). In the majority of NF cases, the history is of slow (over several weeks' duration) or no growth (Price et al, 1961). Our case was clinically fulminant with a history of a rapidly growing mass of a few hours' duration.…”

Section: Discussionmentioning

confidence: 79%

Unusual presentation of nodular fasciitis as a rapidly growing haemorrhagic temporal mass

Jovanović

Čvorović

Milosevic

et al. 2012

Journal of Cranio-Maxillofacial Surgery

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“…22 Intra-articular nodular fasciitis has also been described and is reported to contain prominent stromal hyalinization. 23 Although nodular fasciitis is typically composed of loosely arranged fascicles of (myo)fibroblastic cells with a 'tissue culture-like' growth pattern, Price et al 24 were the first to recognize three variants of nodular fasciitis: myxoid, cellular, and fibrous subtypes. The conventional view is that these variants likely represent chronological stages of evolving nodular fasciitis.…”

Section: Discussionmentioning

confidence: 99%

USP6 genetic rearrangements in cellular fibroma of tendon sheath

et al. 2016

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Fibroma of tendon sheath is a benign (myo)fibroblastic neoplasm of the tenosynovial soft tissues, typically affecting the distal extremities. It is classically described as a paucicellular, densely collagenized tumor; however, cellular variants have been described. A subset of cellular fibromas of tendon sheath shares similar histological features with nodular fasciitis. As nodular fasciitis very frequently harbors rearrangement of ubiquitin-specific peptidase 6 (USP6), we hypothesized that cellular fibromas of tendon sheath with nodular fasciitis-like features may also contain USP6 rearrangements. Cases of fibroma of tendon sheath (n = 19), including cellular (n = 9) and classic (n = 10) variants, were evaluated for USP6 rearrangement by fluorescence in situ hybridization studies. A subset of cases was tested for MYH9 rearrangements and MYH9-USP6 and CDH11-USP6 fusion products. Classic fibroma of tendon sheath occurred in 5 males and 5 females (median age 67 years, range 23-77 years) as soft tissue masses of the hand (n = 4), finger (n = 3), forearm (n = 1) and foot (n = 2). Cellular fibroma of tendon sheath occurred in 5 males and 4 females in a younger age group (median age 32 years, range 12-46 years) as small soft tissue masses of the finger (n = 5), hand (n = 3) and wrist (n = 1). USP6 rearrangements were detected in 6/9 cellular fibromas of tendon sheath. Among cellular fibromas of tendon sheath with USP6 rearrangements, no MYH9 rearrangements were detected. By RT-PCR, neither the MYH9-USP6 or the CDH11-USP6 fusion products were detected in any case. Neither USP6 nor MYH9 rearrangement were detected in any classic fibroma of tendon sheath. We report for the first time the presence of USP6 rearrangements in a subset of cellular fibroma of tendon sheath. Based on the similar morphological and molecular genetic features, we suspect that a subset of cellular fibromas of tendon sheath are under-recognized examples of tenosynovial nodular fasciitis, driven by alternate USP6 fusion genes. Further investigation will delineate how these lesions should best be classified.

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Nodular Fasciitis: A Clinicopathologic Analysis of 65 Cases

Cited by 242 publications

References 0 publications

Nodular Fasciitis of the Face Diagnosed by US-Guided Core Needle Biopsy: A Case Report

Nodular Fasciitis of the Face Diagnosed by US-Guided Core Needle Biopsy: A Case Report

Unusual presentation of nodular fasciitis as a rapidly growing haemorrhagic temporal mass

USP6 genetic rearrangements in cellular fibroma of tendon sheath

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