Nodular fasciitis of the breast: clinicopathologic and molecular characterization with identification of novel USP6 fusion partners

Cloutier, Jeffrey M.; Kunder, Christian A.; Charville, Gregory W.; Hosfield, Elizabeth M.; García, Joaquín J.; Brown, Ryanne A.; Troxell, Megan L.; Allison, Kimberly H.; Bean, Gregory R.

doi:10.1038/s41379-021-00844-4

Cited by 18 publications

(23 citation statements)

References 38 publications

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“…Due to its benign clinical course and limited capacity for recurrence, NF of the breast does not require radical surgical resection. Most patients can be successfully treated with local resection alone, while some may spontaneously resolve without any treatment [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Nodular fasciitis of the breast: the report of three cases

Wanling

Bao

2022

BMC Women's Health

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Background Nodular Fasciitis is a benign fibroblastic proliferation in soft tissues, which mostly occurs in the upper extremities, trunk, head and neck region. It is rarely reported to occur in the breast. Case presentation Herein, we present sonograms of nodular fasciitis in the breast at different durations in three cases. In Case 1, we provided the longest follow-up time in all literatures. In Case 2 and Case 3, we provided the automated breast ultrasound finding of breast nodular fasciitis for the first time. Conclusion Nodular Fasciitis shows clinical features and ultrasonography findings are similar to those of breast cancer. For superficially located breast lesions with a single and rapid growth, nodular fasciitis may be considered in the differential diagnosis of benign entities resembling malignant tumors on breast imaging.

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Section: Discussionmentioning

confidence: 99%

Nodular fasciitis of the breast: the report of three cases

Wanling

Bao

2022

BMC Women's Health

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“…In these cases, in which fluorescence in situ hybridization (FISH) demonstrates USP6 rearrangements, surgical treatment can be safely avoided, as nodular fasciitis is a self-limited process. 14,15 Treatment recommendations: if the diagnostic features are straightforward (without morphologic or immunohistochemical aberrations), patients can avoid surgery even in the absence of USP6 rearrangement confirmation.…”

Section: Nodular Fasciitismentioning

confidence: 99%

Low to Intermediate (Borderline) Grade Breast Spindle Cell Lesions on Needle Biopsy: Diagnostic Approach and Clinical Management

Russell

Montgomery²,

Susnik³

2022

Advances in Anatomic Pathology

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Spindle cell proliferations of the breast are a heterogeneous group of lesions ranging from benign or reactive lesions to aggressive malignant neoplasms. Diagnosis on core biopsy can be particularly challenging as lesions displaying different lineages associated with variable outcomes share overlapping morphologies (scar vs. fibromatosis-like metaplastic carcinoma) whereas individual entities can exhibit a large variety of appearances (myofibroblastoma). In this review, lesions are grouped into lineage, when possible, including those showing fibroblastic/myofibroblastic differentiation, ranging from entities that require no additional management, such as scar and nodular fasciitis, to those with unpredictable clinical outcomes such as fibromatosis and solitary fibrous tumor or locally aggressive behavior such as dermatofibrosarcoma protuberans. The review of low-grade vascular lesions includes atypical vascular lesion and low-grade angiosarcoma. Also discussed are various adipocytic lesions ranging from lipoma to liposarcoma, and rare smooth muscle and neural entities more commonly encountered in locations outside the breast, such as leiomyoma, neurofibroma, schwannoma, or granular cell tumor. Optimal histological evaluation of these entities merges clinical and radiologic data with morphology and ancillary testing. We present our approach to immunohistochemical and other ancillary testing and highlight issues in pathology correlation with imaging. Recent updates in the management of breast spindle cell lesions are addressed. In a well-sampled lesion with radiographic concordance, the core biopsy diagnosis reliably guides management and we advocate the inclusion of management recommendations in the pathology report. Precise characterization using up to date guidelines is important to identify a subset of patients who may safely avoid unnecessary surgical procedures. A multidisciplinary approach with close collaboration with our clinical colleagues is emphasized.

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“…14 In challenging cases, fluorescence in situ hybridisation (FISH) or other molecular techniques to assess for USP6 rearrangement can be helpful, since fusions involving this gene (most commonly MYH9::USP6) are characteristic. 12,15…”

Section: N O D U L a R F A S C I I T I Smentioning

confidence: 99%

“…Nodular fasciitis is positive for SMA, while negative staining for keratins and p63 helps to exclude metaplastic carcinoma 14 . In challenging cases, fluorescence in situ hybridisation (FISH) or other molecular techniques to assess for USP6 rearrangement can be helpful, since fusions involving this gene (most commonly MYH9 :: USP6 ) are characteristic 12,15 …”

Section: Introductionmentioning

confidence: 99%

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Mesenchymal lesions of the breast

Anderson

Fletcher

2022

Histopathology

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Mesenchymal lesions of the breast are a heterogeneous range of entities with diverse clinical, histological, and molecular features, as well as biological behaviour. Their morphologic overlap with non‐mesenchymal lesions (such as metaplastic carcinoma and phyllodes tumour) and relative rarity also pose significant diagnostic challenges. In this review, we summarize the salient features of selected mesenchymal lesions of the breast, emphasizing those that are the most common and problematic. Vascular, fibroblastic/myofibroblastic, adipocytic, and smooth muscle lesions are each covered with regard to their clinicopathological features and differential diagnosis, while recent advances and the role of immunohistochemistry and molecular tests are also highlighted.

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Nodular fasciitis of the breast: clinicopathologic and molecular characterization with identification of novel USP6 fusion partners

Cited by 18 publications

References 38 publications

Nodular fasciitis of the breast: the report of three cases

Nodular fasciitis of the breast: the report of three cases

Low to Intermediate (Borderline) Grade Breast Spindle Cell Lesions on Needle Biopsy: Diagnostic Approach and Clinical Management

Mesenchymal lesions of the breast

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