Nodular Goiter and Malignant Lesions of the Thyroid Gland*

Beahrs, Oliver H.; Pemberton, John deJ.; Black, Bruce

doi:10.1210/jcem-11-10-1157

Cited by 99 publications

(21 citation statements)

References 7 publications

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“…In our study, in GD patients, the rate of malignancy is 7.0%, which is similar to the rates in previous studies. It is suggested that the wide variation in incidence could be due to the differences in the extent of resection as well as in the number of histological sections examined per specimen [3]. Although different mechanisms are suggested to explain Graves' disease and pathogenesis of thyroid cancer, they seem to be contradictory and inefficient [14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of incidental thyroid cancer and its ultrasonographic features in subcentimeter thyroid nodules of patients with hyperthyroidism

Berker

Işık

Özuğuz

et al. 2010

Endocr

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In patients, who undergo surgery for hyperthyroidism, many cases of incidental thyroid cancer (ITC) have been detected. In the literature, there is no study about ITC in subcentimeter nodules in these patients. We performed this study to determine the frequency of ITC in subcentimeter nodules and ultrasonographic features that can predict malignancy in the patients with hyperthyroidism. We retrospectively reviewed our database about 3114 patients, who underwent thyroidectomy in our hospital. Among 869 patients (27.9%), who were operated because of hyperthyroidism, we enrolled 337 patients, who underwent total thyroidectomy and had subcentimeter nodule [59 Graves’ disease (GD) 98 subcentimeter nodule; 278 toxic multinodular goitre (TMNG), 359 subcentimeter nodule], in this study. Twenty-five nodules with ITC and 432 benign nodules have been detected and compared for ultrasonographic (US) features. Incidental thyroid cancer detection ratio was 5.4% [10.2% (10/98) in subcentimeter thyroid nodules in individuals with GD, and 4.1% (15/359) in individuals with TMNG, P = 0.018)]. Significant differences have been observed between the groups in terms of microcalcification in US examination of malign and benign subcentimeter thyroid nodules and the ratio of anterioposterior diameter to transverse diameter (A/T) ≥1 [(OR = 5.172; 95% CI: 1.495–17.886, P = 0.015), and (OR = 5.930; 95% CI: 1.531–22.971, P = 0.007), respectively]. We detected a higher incidence of ITC in subcentimeter thyroid nodules in GD compared to TMNG. US examination of subcentimeter nodules in hyperthyroid individuals has indicated that microcalcification and ratio of A/T ≥1 are the parameters that predict malignancy.

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Section: Discussionmentioning

confidence: 99%

“…Some reports stress that hyperthyroidism and cancer rarely occur simultaneously [3][4][5]. However, many recent studies show that finding an incidental thyroid cancer (ITC) among patients operated for a benign thyroid disease is not infrequent.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of incidental thyroid cancer and its ultrasonographic features in subcentimeter thyroid nodules of patients with hyperthyroidism

Berker

Işık

Özuğuz

et al. 2010

Endocr

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“…First, all of the previous studies retrospectively examined patients with Graves disease who were surgically treated, and the results deserve to be examined in some detail. In the earliest reports, thyrotoxicosis was considered insurance against thyroid cancer, a conclusion based mainly on the results of Beahrs et al 25 and Sokal, 26 who reported incidences of carcinoma in patients with Graves disease of 0.5% and 0.15%, respectively. Shapiro et al 1 and subsequent reports [2][3][4][5][6][7][8][9] indicated that the coexistence of Graves disease and thyroid carcinoma was not rare.…”

Section: Commentmentioning

confidence: 99%

Thyroid Nodules in Graves Disease and the Risk of Thyroid Carcinoma

L¹,

Baldini²,

Orsatti³

et al. 1999

Arch Intern Med

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“…[7][8][9] Some reports emphasized the rarity of hyperthyroidism and cancer occurring simultaneously. [10][11][12] Several investigators have since found that thyroid nodules are common in patients with Graves' disease, 1,[13][14][15][16][17][18] and it also seems that patients with Graves' disease and a thyroid nodule have a very high risk of thyroid cancer. 19 Some authors suggest that thyroid carcinomas associated with Graves' hyperthyroidism are more aggressive than those arising in patients with nonautoimmune hyperthyroidism or in euthyroid patients.…”

Section: Introductionmentioning

confidence: 99%