Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study

Abstract

We report the case of a 24-year-old woman with nodular hidradenocarcinoma on the scalp. While histopathology of the tumor showed a circumscribed, lobulated intradermal mass with prominent squamous differentiation, the immunohistochemical study with antibodies to cytokeratins, CAM 5.2 and 19, epithelial membrane antigen, carcinoembryonic antigen, S-100 protein and p53 all demonstrated positivity. These findings confirmed that the tumor was of eccrine sweat gland origin and it was thought to be a nodular hidradenocarcinoma differentiating toward the eccrine duct and/or secretory portions. She was treated with a wide local excision and no recurrence was observed 18 months after excision.

Subcutaneous porocarcinoma clinically presenting as a soft tissue tumor

“…In this case, the tumor completely lacked epidermal involvement and macroscopically showed nodular growth pattern. Therefore, clear cell (nodular) hidradenocarcinoma should be taken into account as a differential diagnosis, and it has been reported that some hidradenocarcinomas also show marked squamous differentiation . Although it is virtually difficult to make a clear distinction between hidradenocarcinoma and porocarcinoma, the tumor was mainly composed of poroid cells, accompanied by cuticular cells, suggesting the latter.…”

Hidradenocarcinoma of scalp: a case report and review of literature

“…3 A case report of hidradenocarcinoma by ohta et al and Park et al, have concluded that early wide local excision of the tumour is the treatment of choice. 7,12 In their case reports, patients were only treated with wide local excision and there was no recurrence observed in 24 months and 16 months of follow up respectively. In a study by Stanislav et al, the authors performed a retrospective review of hidradenocarcinoma patients treated with Mohs micrographic surgery at Mayo clinic from 1993 to 2013 and they found that Mohs micrographic surgery seems to be a useful treatment modality and there was no recurrence, metastasis and disease related mortality in patients treated with Mohs micrographic surgery.…”

Malignant Nodular Hidradenoma on the Scalp

“…MNH presents a nodular or lobulated architecture of clear cells with glycogencontaining cytoplasm and tubular or ductal structures, together with a large or small representation of cells showing squamoid differentiation. 2, [5][6][7][8][9][10][11][12][13] There are several reports in the literature, some quite brief, of the cytologic characteristics of MNH 7-9,13 and NH. [13][14][15][16][17] In their cytologic description of NH, Kumar and Verma 14 indicated that unusual cytomorphologic features and a diversity of cell types, such as polygonal cells, clear cells and spindle cells, should raise the suspicion of a cutaneous adnexal tumor.…”

“…Overexpression of p53 and Ki67 is associated with the malignant component of the tumor. 2,6,11,[18][19][20] In the case presented above, both were positive in all the areas examined and in cytologic material could prove helpful for distinguishing between the benign and malignant forms of the tumor. The fact that a cell block can be obtained from FNA material facilitates the use of these diagnostic techniques.…”