Nodular melanoma: Patients' perceptions of presenting features and implications for earlier detection

Chamberlain, Alex J; Fritschi, Lin; Kelly, John W.

doi:10.1067/mjd.2003.216

Cited by 148 publications

(133 citation statements)

References 26 publications

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“…30 It must also be emphasized that the time over which this change occurs is typically shorter for NMs than for SSMs. 11 Consistent with this, we found that the median duration of NMs was only 5 months compared with 9 months for SSMs, suggesting that the clinically aggressive biology of these tumors, rather than delays in seeking medical attention, may account for their advanced thickness. Given this rapid rate of growth, the implementation of self-detection strategies, including education on how to perform skin selfexaminations, becomes critically important as a means of secondary prevention for NM.…”

Section: Discussionsupporting

confidence: 71%

“…8,9 NMs often fail to fulfill the original ABCD diagnostic criteria, possibly contributing to their advanced stage at presentation. 10,11 Evidence in support of the distinct clinical behavior of NMs has also been demonstrated in data on sentinel lymph node (SLN) status, where NMs have been associated with a higher incidence of recurrence in the SLN basin compared with other subtypes. 12,13 Given the higher proportion of NMs among thick tumors, previous studies have sought to better define their clinical presentation and biologic behavior in attempts to facilitate early detection.…”

Section: Introductionmentioning

confidence: 91%

“…12,13 Given the higher proportion of NMs among thick tumors, previous studies have sought to better define their clinical presentation and biologic behavior in attempts to facilitate early detection. Several of these studies suffer limitations, including a small sample size, 11,14 the reporting of a few select parameters, 12,15 or the failure to provide follow-up information. 16 Our study represents the largest analysis of NMs from a single United States institution that we are aware of to date, and reports on both clinical and histopathologic features of these tumors.…”

Section: Introductionmentioning

confidence: 99%

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Changes in the presentation of nodular and superficial spreading melanomas over 35 years

2009

Journal of the American Academy of Dermatology

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BACKGROUND-Nodular melanoma (NM) may be biologically aggressive compared with the more common superficial spreading melanoma (SSM), with recent data suggesting underlying genetic differences between these 2 subtypes. To better define the clinical behavior of NMs, the authors compared their clinical and histopathologic features to those of SSMs at their institution, a tertiary referral center, over 3 decades.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Changes in the presentation of nodular and superficial spreading melanomas over 35 years

2009

Journal of the American Academy of Dermatology

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“…17 The asymmetry, border irregularity, color variegation, and diameter >6 mm (ABCD) system for the recognition of early melanoma does not apply well to this histologic type, and the shorter period of growth limits the opportunity for early detection, even in patients under regular surveillance for melanoma screening. 19 The addition of an ''E'' for ''evolving'' to the ABCD system may improve and enhance early recognition by clinicians and laypersons. 20 We advocate the expansion of current preventive educational reminders to the elderly as well as to their immediate environment.…”

Section: Discussionmentioning

confidence: 99%

Age and gender are significant independent predictors of survival in primary cutaneous melanoma

Lasithiotakis¹,

Leiter²,

Meier³

et al. 2008

Cancer

229

178

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BACKGROUNDThe aim was to identify age‐ related and gender‐related differences in the clinical presentation and outcome of patients with primary cutaneous melanoma (CM).METHODSA total of 4785 CM patients without clinical evidence of metastasis diagnosed during the period 1976–2001 in southern Germany included in the analysis. Kaplan‐Meier analyses were performed to estimate and to compare disease‐specific survival (DSS) and survival after first recurrence (SAR). The Cox proportional hazards model was used to evaluate the effect of multiple variables on DSS and SAR.RESULTSIncreasing age and male gender were independently associated with thicker tumors (>2 mm) and histologic ulceration (P < .001). Patients older than 65 years had lower 10‐year DSS than younger patients (81.8% vs 88.4%, P < .001) and this difference was more pronounced in women (P < .001) than in men (P = .06). Males had lower 10‐year DSS than females (83.5% vs 88.5%, P < .001) but this difference did not reach statistical significance in patients older than 65 years (P = .162). In multivariate analysis adjusted for tumor thickness, ulceration, anatomic site, histologic subtype, DSS, site of first recurrence, time trend, sentinel lymph node status, age, and gender were independent predictors of DSS and SAR (P < .05).CONCLUSIONSOlder age and male gender are associated with prognostically unfavorable primary CM. Expansion of current preventive strategies to target these subgroups is warranted. Moreover, age and gender are independent predictors of the outcome of CM patients. Females have a better prognosis than males but this difference disappears after the age of 65. Younger patients have a more favorable prognosis than older patients, a difference more pronounced in women. Cancer 2008. © 2008 American Cancer Society.

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“…The capacity of melanin production was suggested to correlate with the differentiation and maturation status of melanocytes (46). Thus, we examined the levels of melanin in both cell types and found that NCAM silencing increased the pigmentation of siNCAM cells, and the production of melanin was also consistently increased in medium (Fig.…”

Section: Ncam Silencing Decreases the Proliferation And Promotesmentioning

confidence: 99%

Neural Cell Adhesion Molecule Potentiates the Growth of Murine Melanoma via β-Catenin Signaling by Association with Fibroblast Growth Factor Receptor and Glycogen Synthase Kinase-3β

Shi

Yang

et al. 2011

Journal of Biological Chemistry

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The neural cell adhesion molecule (NCAM) was recently shown to be involved in the progression of various tumors with diverse effects. We previously demonstrated that NCAM potentiates the cellular invasion and metastasis of melanoma. Here we further report that the growth of melanoma is obviously retarded when the expression of NCAM is silenced. We found that the proliferation of murine B16F0 melanoma cells, their colony formation on soft agar, and growth of transplanted melanoma in vivo are clearly inhibited by the introduction of NCAM siRNA. Interestingly, change of NCAM expression level is shown to regulate the activity of Wnt signaling molecule, ␤-catenin, markedly. This novel machinery requires the function of FGF receptor and glycogen synthase kinase-3␤ but is independent of the Wnt receptors, MAPK-Erk and PI3K/Akt pathways. In addition, NCAM is found to form a functional complex with ␤-catenin, FGF receptor, and glycogen synthase kinase-3␤. Moreover, up-regulation of NCAM140 and NCAM180 appears more potent than NCAM120 in activation of ␤-catenin, suggesting that the intracellular domain of NCAM is required for facilitating the ␤-catenin signaling. Furthermore, the melanoma cells also exhibit distinct differentiation phenotypes with the NCAM silencing. Our findings reveal a novel regulatory role of NCAM in the progression of melanoma that might serve as a new therapeutic target for the treatment of melanoma.Melanoma arises from skin neural crest-derived pigmented melanocytes and accounts for around 80% of mortality of skin cancer (1) with less than 5% of a 5-year survival rate (2). The rapid growth of melanoma cells by overriding senescence and activation of pro-proliferating signal transduction were shown to play a key role in the development of melanoma into metastatic stage (3). Even though many cell growth promoting factors have been identified to be involved in the progression of melanoma and targeted for therapeutic intervention, the treatment efficacy of advanced melanoma with vertical growth and metastasis has not been significantly improved over the past few decades (1). Hence, further study to elucidate the molecular mechanisms underlying the proliferation of melanoma cells is required for the finding of novel potential intervention targets to improve the treatment of melanoma.It has been demonstrated that the adhesion molecules that mediate intercellular and cell-matrix interactions extensively participate in the progression of melanoma (4, 5) by altering the adhesion status and signal transduction of the cells. Neural cell adhesion molecule (NCAM), 2 a member of the immunoglobulin superfamily, has been well characterized in cell proliferation, differentiation, migration, neurite outgrowth, and synaptic plasticity in the nervous system (6 -9). However, recent studies have also revealed that the expression of NCAM drastically fluctuates in many tumors and affects tumor progression and prognosis (10). In small cell lung cancer (11) and the majority of multiple myelomas (12), the up-regulation of NC...

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Nodular melanoma: Patients' perceptions of presenting features and implications for earlier detection

Cited by 148 publications

References 26 publications

Changes in the presentation of nodular and superficial spreading melanomas over 35 years

Changes in the presentation of nodular and superficial spreading melanomas over 35 years

Age and gender are significant independent predictors of survival in primary cutaneous melanoma

Neural Cell Adhesion Molecule Potentiates the Growth of Murine Melanoma via β-Catenin Signaling by Association with Fibroblast Growth Factor Receptor and Glycogen Synthase Kinase-3β

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