Nodular morphoea: a first case associated with linear morphoea

Nakazato, Shinichi; Nomura, Toshifumi; Yamane, Naoko; Shinkuma, Satoru; Natsuga, Ken; Fujita, Yasuyuki; Arita, Ken; Shimizu, Hiroshi

doi:10.1684/ejd.2015.2656

Cited by 3 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since then there have been several additional published case reports of keloidal morphea/nodular scleroderma occurring in a linear distribution. In two reported cases, the scleroderma nodules appeared to have developed in pre-existing linear scleroderma indurated plaques [5,6]. However, in our case the nodules were discrete and non-contiguously arrayed in a linear fashion.…”

Section: Case Discussioncontrasting

confidence: 47%

Questions raised by a case of adult-onset linear nodular scleroderma

Marcelus¹,

Jimenez²,

Zussman³

et al. 2022

DOJ

View full text Add to dashboard Cite

Section: Case Discussioncontrasting

confidence: 47%

Questions raised by a case of adult-onset linear nodular scleroderma

Marcelus¹,

Jimenez²,

Zussman³

et al. 2022

DOJ

View full text Add to dashboard Cite

“…Concurrent and distinct nodular/keloidal and linear sclerodermic skin changes have not been previously described. We found two cases of nodular lesions developing within areas of linear morphea [11,12], and two cases of multiple nodular sclerotic lesions following a linear distribution [13,14], but the coexistence of nodular/keloidal and linear sclerotic lesions arising distinctively in separate body regions has not been reported. Jain K et al [12] suggested an underlying genetic mosaicism, since their patient had a linear plaque that had developed along the Blaschko lines on the lower extremity; nonetheless, the dermatomal distribution is controversial, and the other reported case of nodules developing on linear sclerotic plaques [11] did not follow a blaschkoid pattern.…”

Section: Discussionmentioning

confidence: 81%

Nodular/Keloidal Scleroderma with No Systemic Involvement—A Case Report and a Review of the Literature

Trufin,

Ungureanu,

Halmágyi

et al. 2024

JCM

View full text Add to dashboard Cite

Nodular or keloidal scleroderma is a rare condition with unclear cause and sporadic mentions in the medical literature. It was first recognized in the 19th century, yet its classification is still debated due to the limited number of reported cases. This rare variant of scleroderma is associated with either progressive systemic sclerosis or localized morphea. Clinically, it presents with asymptomatic nodules or plaques, resembling spontaneous keloid formation, often found on the trunk and proximal extremities. Recent literature reviews show a predominance of women with a mean age of 44 years. Diagnosis relies on clinical and histopathological findings, which usually show overlapping features of both scleroderma and true keloids, secondarily to an excessive fibrosing reaction attributed to collagen formation. We present an unusual case of a 70-year-old female patient who displayed the coexistence of two distinct subtypes of morphea (nodular/keloidal and linear), and exclusive skin involvement, which contrasts with the typical presentation of nodular/keloidal scleroderma, often associated with organ-specific disease. However, recent publications have diverged from previous ones regarding systemic sclerosis, with no systemic involvement reported between 2018 and 2024, which we evaluated in our descriptive literature review. With less than 50 cases reported in total, our case underlines the importance of recognizing this rare disease, ensuring appropriate evaluation, treatment, and follow-up.

show abstract

Nodular Sclerodermatous Chronic Cutaneous Graft-Versus-Host Disease (GvHD): A New Clinicopathological Variant of Cutaneous Sclerodermatous GvHD Resembling Nodular/Keloidal Scleroderma

Prieto‐Torres

Boggio

Gruber‐Wackernagel

et al. 2017

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Cutaneous chronic graft-versus-host disease (GvHD) has a broad spectrum of clinicopathological presentations, the most common ones being poikiloderma, lichen planus-like eruptions, lichen sclerosus-like lesions, morphea-like plaques, and deep sclerosis. New forms of chronic cutaneous GvHD with different clinicopathological characteristics have been described, most of them mimicking cutaneous manifestations of autoimmune diseases. We report the case of a 35-year-old man who underwent allogenic stem cell transplantation for a therapy-associated acute myeloid leukemia and developed an acute GvHD with involvement of skin and gastrointestinal tract. He subsequently presented with chronic sclerodermatous cutaneous GvHD, followed by the appearance of indurated erythematous papules and plaques located on his back, resembling the nodular/keloidal form of cutaneous scleroderma on both clinical and histopathological grounds. This peculiar clinicopathologic presentation of chronic cutaneous GvHD was never described previously.

show abstract

Nodular morphoea: a first case associated with linear morphoea

Cited by 3 publications

References 8 publications

Questions raised by a case of adult-onset linear nodular scleroderma

Questions raised by a case of adult-onset linear nodular scleroderma

Nodular/Keloidal Scleroderma with No Systemic Involvement—A Case Report and a Review of the Literature

Nodular Sclerodermatous Chronic Cutaneous Graft-Versus-Host Disease (GvHD): A New Clinicopathological Variant of Cutaneous Sclerodermatous GvHD Resembling Nodular/Keloidal Scleroderma

Contact Info

Product

Resources

About