Nodular pulmonary amyloidosis: a complex disease with malignancy association

Abstract

Pulmonary amyloidosis is a rare disease that incorporates deposition of amyloid microfibril material in the lung parenchyma. The condition generally presents as an indolent subacute-to-chronic pulmonary disease and requires tissue biopsy to establish the diagnosis. Nodular pulmonary amyloidosis, a subtype of pulmonary amyloidosis, is characterised by special radiographic and pathological features. While the disease can be associated with inflammatory conditions; its association with mucosal-associated lymphoid tissue (MALT lymphoma) is unusual and carries management challenges. Herein, we illustrate a case study of nodular pulmonary amyloidosis associated with underlying MALT lymphoma in a patient with known systemic lupus erythematosus. The aim of this article is to share the management experience of this complex condition with the medical community and to conduct an up-to-date literature review on nodular pulmonary amyloidosis.

Uncommon Presentation of Undiagnosed B-Cell Lymphoproliferative Disorder as Nodular Pulmonary Amyloidosis

“…Here we are giving a comprehensive review of similar case reports published by other authors (Table 1) [22][23][24][25][26][27][28][29][30].…”

Isolated pulmonary amyloidoma: A rare cause of solitary pulmonary nodule

“…One benign cause of such a nodule is localized nodular pulmonary amyloidoma (NPA) which is a rare condition without systemic symptoms of amyloidosis [ 3 , 4 ]. Amyloidosis is a heterogenous disease characterized by misfolded proteins deposited extracellularly [ 1 , 3 , 5 ]. This leads to cell death and eventually organ damage [ 1 ].…”

“…This leads to cell death and eventually organ damage [ 1 ]. It is histologically associated with Congo Red stain with apple-green birefringence under polarized light [ 5 ]. Amyloidosis has four general subtypes depending on the type of amyloid protein involved [ 5 ].…”

“…It is histologically associated with Congo Red stain with apple-green birefringence under polarized light [ 5 ]. Amyloidosis has four general subtypes depending on the type of amyloid protein involved [ 5 ]. The AL protein is an immunoglobulin-derived light chain protein, and AL-amyloidosis can affect the heart, lungs, kidney GI, and nervous system [ 5 ].…”

“…Amyloidosis has four general subtypes depending on the type of amyloid protein involved [ 5 ]. The AL protein is an immunoglobulin-derived light chain protein, and AL-amyloidosis can affect the heart, lungs, kidney GI, and nervous system [ 5 ]. It is also associated with plasma cell dyscrasias and most often associated with lung pathology [ 5 ].…”