Nodular Thyroid Disease Diagnosed During Pregnancy: How and When to Treat

Hay, Ian D.

doi:10.1089/thy.1999.9.667

Cited by 19 publications

(6 citation statements)

References 24 publications

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“…If surgery is decided upon, it may be performed in the second trimester, preferably in week 22. If diagnosis occurs later, surgery is indicated after delivery (20,23,24).…”

Section: Discussionmentioning

confidence: 99%

Evolution of differentiated thyroid cancer during pregnancy in a community University Hospital in Buenos Aires, Argentina

Cabezón

Carrizo

Costanzo

2013

Arq Bras Endocrinol Metab

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Objective: To analyze the presentation, follow-up and evolution of differentiated thyroid cancer (DTC) detected during pregnancy. Subjects and methods: Twenty nine women with DTC detected during pregnancy were analyzed. Group I (n = 13) was seen during pregnancy and DTC was diagnosed during gestation; detection of the nodule occurred during pregnancy (first trimester). Group II (n = 16) was seen after delivery; detection of the nodule occurred during pregnancy (second or third trimester). Complete thyroidectomy, ablative dose of radioactive iodine, and treatment with levothyroxine were performed. Follow-up: neck ultrasound; TSH, free T4, thyroglobulin, and anti-thyroglobulin antibodies with and without treatment with levothyroxine; and 131 I whole body scans. Histological diagnosis, lymph node metastases, tumor size and stage, complications from pregnancy, and DTC evolution were evaluated. Results: 100% of the patients had papillary thyroid carcinoma. Lymph node metastases were detected in 13 (44.8%), and invasion of adjacent extrathyroid tissue in 2 patients. Tumor size was larger in Group II: 22.1 ± 10.9 versus 13.9 ± 3.5 mm; p = 0.03. No differences were found in the tumor stages between groups. All patients had full-term pregnancies and healthy newborns. Follow-up: 5.7 ± 4.3 years; one patient had persistent disease. Conclusions: DTC detected during pregnancy had a favorable evolution. Surgery may be postponed to the post-delivery period, unless there are risk factors that justify it during pregnancy. Arq Bras Endocrinol Metab. 2013;57(4):307-11

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“…If surgery is decided upon, it may be performed in the second trimester, preferably in week 22. If diagnosis occurs later, surgery is indicated after delivery (20,23,24).…”

Section: Discussionmentioning

confidence: 99%

Evolution of differentiated thyroid cancer during pregnancy in a community University Hospital in Buenos Aires, Argentina

Cabezón

Carrizo

Costanzo

2013

Arq Bras Endocrinol Metab

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“…Thyroid cancer is the most frequent endocrine malignancy and occurs in all adult age groups, but affects women two to four times more often than men . In women, the highest incidence occurs between the ages of 30 and 50, making diagnosis during pregnancy not rare . Of all cancers diagnosed during pregnancy, thyroid cancer is one of the most common with 6% to 10% prevalence .…”

Section: Introductionmentioning

confidence: 99%

“…1 In women, the highest incidence occurs between the ages of 30 and 50, making diagnosis during pregnancy not rare. [2][3][4] Of all cancers diagnosed during pregnancy, thyroid cancer is one of the most common with 6% to 10% prevalence. [5][6][7][8] The prognosis of thyroid cancer in the general population mainly depends on the histopathological subtype and stage of disease at diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Maternal and obstetrical outcome in 35 cases of well‐differentiated thyroid carcinoma during pregnancy

et al. 2017

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“…Hay [45] reported a series of 39 pregnant patients seen at the Mayo Clinic over a 10-year period who underwent FNAB for a thyroid nodule. Of these, 64% were benign, 8% positive for PTC and 9 were suspicious for PTC or follicular neoplasm.…”

Section: Indications For Surgery Of Thyroid Cancer During Pregnancymentioning

confidence: 99%

“…These articles [43][44][45][46] generally demonstrate the lack of urgency in treating pregnant women who have apparently non-aggressive well-diVerentiated thyroid cancer, and that FNABs are often reliable in guiding therapy. They also recognize that surgery can be performed very safely during pregnancy and may serve to relieve the mother's anxiety while oVering an earlier cure for the neoplastic condition.…”

Section: Indications For Surgery Of Thyroid Cancer During Pregnancymentioning

confidence: 99%

Thyroid and parathyroid surgery in pregnancy

Owen

Chou

Silver

et al. 2010

Eur Arch Otorhinolaryngol

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The consideration of surgery during pregnancy requires weighing the benefit of urgent surgery against the risk to mother and fetus. Surgery during pregnancy involves an increase in both maternal and fetal risks. Thyroid and parathyroid surgery involves physiological risks to both mother and fetus specific to the disease and function of these endocrine glands. Evaluation of a thyroid mass is similar in pregnant patients with ultrasound and fine-needle aspiration biopsy providing the most important information, while the use of radiographic imaging is severely constrained except when specifically required. In general, thyroid surgery can be delayed until after delivery except in cases of airway compromise or aggressive cancer. In contrast, parathyroid surgery is recommended during pregnancy to avoid adverse effects to the neonate.

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Nodular Thyroid Disease Diagnosed During Pregnancy: How and When to Treat

Cited by 19 publications

References 24 publications

Evolution of differentiated thyroid cancer during pregnancy in a community University Hospital in Buenos Aires, Argentina

Evolution of differentiated thyroid cancer during pregnancy in a community University Hospital in Buenos Aires, Argentina

Maternal and obstetrical outcome in 35 cases of well‐differentiated thyroid carcinoma during pregnancy

Thyroid and parathyroid surgery in pregnancy

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