Nodulocystic basal cell carcinoma arising directly from a seborrheic keratosis: A rare case report

Shibao, Kana; Okiyama, Naoko; Tanaka, Ryota; Maruyama, Hitoshi; Fujisawa, Yasuhiro; Fujimoto, Manabu

doi:10.4103/0019-5154.185720

Cited by 7 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combined cases of seborrheic keratosis and basal cell carcinoma have also been reported in several articles. 12,15,16,28,[40][41][42][43][44][45][46][47][48][49] In such cases, the transition from seborrheic keratosis to basal cell carcinoma has not been clearly confirmed. Instead, nests of basal carcinoma are scattered throughout the seborrheic keratosis or collide with adjoining seborrheic keratosis.…”

Section: Discussionmentioning

confidence: 99%

Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases

Goto

Ogawa

Hishima

et al. 2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Seborrheic keratosis is a common benign neoplasm composed of basaloid keratinocytes. However, little is known about the malignant transformation of the tumor. Eleven cases of seborrheic keratosis with malignant transformation were analyzed. The 11 patients included 5 male patients and 6 female patients with a median age of 75 years at diagnosis (68-90 years). The tumors arose at various sites from the scalp (n = 3) to the lower leg (n = 2). The median tumor size was 12 (10-32) and 40 (20-75) mm in 7 noninvasive and 4 invasive cases, respectively. One patient exhibited intransit skin metastasis. Histopathology of the malignant components resembled porocarcinoma or inverted follicular keratosis. Bowenoid and pagetoid spreading was frequently observed. The malignant components expressed cytokeratin 5/6 (100%) and GATA3 (73%), but not cytokeratin 7 (0%), cytokeratin 19 (9%), BerEP4 (0%), c-kit (0%), and NUT (0%). No significant immunoreactivity of YAP1 was observed in any of the cases. Mutant-type immunostaining of p53 and PTEN was observed in 91% and 82% of the cases, respectively. An increase in p16 expression was seen in 6 (86%) of the 7 cases with noninvasive carcinoma, although a loss of p16 immunoexpression was seen in the invasive carcinoma component in 3 (75%) of the 4 cases. This study demonstrated that seborrheic keratosis can undergo malignant transformation, particularly in large-sized lesions in elderly patients. Malignant components mimic porocarcinoma or inverted follicular keratosis. Malignant transformation induced by TP53 and PTEN mutations and tumor invasion by CDKN2A inactivating mutations are suggested in this study.

show abstract

Section: Discussionmentioning

confidence: 99%

Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases

Goto

Ogawa

Hishima

et al. 2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…Controversy exists in the literature as to whether malignant epithelial tumors actually arise from SK or are simply concurrent with them. Some scholars believe that BCC may arise directly from the wall of pseudohorn cysts, 19 and SCC arises from the eosinophilic spinous cell population around pseudohorn cysts, 20 which indicates that secondary tumor may be associated with components in SK. However, a clear delimitation exists between the SK component and the associated carcinoma component, as we observed via microscopy in some cases in our series.…”

Section: Dovepressmentioning

confidence: 99%

Clinical and Histopathological Characteristics of Tumors Arising in Seborrheic Keratosis: A Study of 1365 Cases

Ye¹,

Chen²,

Jia³

et al. 2021

TCRM

View full text Add to dashboard Cite

Objective:The aim of this study was to describe the clinical and histopathological characteristics of seborrheic keratosis (SK) with secondary tumor and identify associated factors. Methods: This study was a monocentric retrospective case-control study describing the factors associated with the development of tumors in SK. A total of 1365 patients with SK were admitted to our department between 2018 and 2021. All of the histopathological specimens and medical records of these patients were reviewed. We compared the data of 36 patients with tumors arising in SK with those of the remaining 1329 patients with only SK, which were designated the control group. Results: The incidence of tumors arising in SK that were biopsied was 2.6%. The tumor types included squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and keratoacanthoma (KA). Compared with other patients with SK, elderly patients with immunosuppression, patients presenting surrounding erythema or ulceration, and those with SK in exposed areas had an increased possibility of developing a secondary tumor. Tumors arising within SK have the histopathological features of ulceration, cytologic atypia, mitosis, "malignant horn", trabecular cell cords, solar elastosis and severe inflammatory infiltration in the dermis. Conclusion: SK can show malignant progression in a small fraction of SK cases that are biopsied. This study is the first report on the clinical and histopathological characteristics of tumors arising in SK and identifies relevant factors in an Asian population.

show abstract

“…Seborrheic keratosis (SK) is one of the most common benign cutaneous tumors. Although it usually has a benign course, malignant tumor, including basal cell carcinoma (BCC) and squamous cell carcinoma, arising within SK has rarely been reported in literature 1 2 .…”

mentioning

confidence: 99%

Basal Cell Carcinoma Arising within Seborrheic Keratosis

et al. 2019

View full text Add to dashboard Cite

Nodulocystic basal cell carcinoma arising directly from a seborrheic keratosis: A rare case report

Cited by 7 publications

References 10 publications

Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases

Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases

Clinical and Histopathological Characteristics of Tumors Arising in Seborrheic Keratosis: A Study of 1365 Cases

Basal Cell Carcinoma Arising within Seborrheic Keratosis

Contact Info

Product

Resources

About