Noise analysis of externally linear systems

Tóth, L.; Efthivoulidis, G.; Tsividis, Y.

doi:10.1109/82.899629

Cited by 8 publications

(1 citation statement)

References 29 publications

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“…signal * noise intermodulation takes place. The case of Externally-Linear-Internally-NonLinear (ELIN), time-invariant responses has been studied both theoretically and by means of measurements and simulations [30],[44],[45]. It has been confirmed that when the input signal increases considerably in strength with respect to the input DC value (for example, in class-AB operation the ratio of these two quantities can be in the range of thousands), then the noise power increases with the power of the input.…”

Section: Robustness and Electrical Properties Of Cytomimetic Circuitsmentioning

confidence: 99%

Systematic Computation of Nonlinear Cellular and Molecular Dynamics with Low-Power CytoMimetic Circuits: A Simulation Study

2013

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This paper presents a novel method for the systematic implementation of low-power microelectronic circuits aimed at computing nonlinear cellular and molecular dynamics. The method proposed is based on the Nonlinear Bernoulli Cell Formalism (NBCF), an advanced mathematical framework stemming from the Bernoulli Cell Formalism (BCF) originally exploited for the modular synthesis and analysis of linear, time-invariant, high dynamic range, logarithmic filters. Our approach identifies and exploits the striking similarities existing between the NBCF and coupled nonlinear ordinary differential equations (ODEs) typically appearing in models of naturally encountered biochemical systems. The resulting continuous-time, continuous-value, low-power CytoMimetic electronic circuits succeed in simulating fast and with good accuracy cellular and molecular dynamics. The application of the method is illustrated by synthesising for the first time microelectronic CytoMimetic topologies which simulate successfully: 1) a nonlinear intracellular calcium oscillations model for several Hill coefficient values and 2) a gene-protein regulatory system model. The dynamic behaviours generated by the proposed CytoMimetic circuits are compared and found to be in very good agreement with their biological counterparts. The circuits exploit the exponential law codifying the low-power subthreshold operation regime and have been simulated with realistic parameters from a commercially available CMOS process. They occupy an area of a fraction of a square-millimetre, while consuming between 1 and 12 microwatts of power. Simulations of fabrication-related variability results are also presented.

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Section: Robustness and Electrical Properties Of Cytomimetic Circuitsmentioning

confidence: 99%