Noise conductance of DNA under salt‐free conditions

Kranck, H.; Hesse-Bezot, C.; Rix-Montel, M.A.; Grassi, H.; Vasilescu, D.

doi:10.1002/bip.1976.360150317

Cited by 6 publications

(1 citation statement)

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“…The dynamics of the ions in water solutions may be characterized by the ionic current that appears under the action of the external electric filed. The experimental studies for DNA in water solution with the different salts of alkali metal ions show that the ionic conductivity essentially depends on the temperature, counterion type and concentration [35][36][37][38][39][40]. The de-pendence of conductivity on counterion type is featured by the ion size, charge and character of hydration [41].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of K$^+$ counterions around DNA double helix in the external electric field: a molecular dynamics study

Zdorevskyi¹,

Perepelytsya²

2020

Preprint

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The structure of DNA double helix is stabilized by metal counterions condensed to a diffuse layer around the macromolecule. The dynamics of counterions in real conditions is governed by the electric fields from DNA and other biological macromolecules. In the present work the molecular dynamics study was performed for the system of DNA double helix with neutralizing K + counterions and for the system of KCl salt solution in the external electric field of different strength (up to 32 mV/ Å). The analysis of ionic conductivities of these systems has shown that the counterions around the DNA double helix are slowed down compared with KCl salt solution. The calculated values of ion mobility are within (0.05÷0.4) mS/cm depending on the orientation of the external electric field relatively to the double helix. Under the electric field parallel to the macromolecule K + counterions move along the grooves of the double helix staying longer in the places with narrower minor groove. Under the electric field perpendicular to the macromolecule the dynamics of counterions is less affected by DNA atoms, and starting with the electric field values about 30 mV/ Å the double helix undergoes a phase transition from doublestranded to single-strand state.

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