2012
DOI: 10.2967/jnumed.111.101733
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Noise Considerations for PET Quantification Using Maximum and Peak Standardized Uptake Value

Abstract: In tumor response monitoring studies with 18F-FDG PET, maximum standardized uptake value (SUVmax) is commonly applied as a quantitative metric. Although it has several advantages due to its simplicity of determination, concerns about the influence of image noise on single-pixel SUVmax persist. In this study, we measured aspects of bias and reproducibility associated with SUVmax and the closely related peak SUV (SUVpeak) using real patient data to provide a realistic noise context. Methods List-mode 3-dimensio… Show more

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Cited by 205 publications
(201 citation statements)
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References 31 publications
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“…Because SUV max and SUV peak have both demonstrated lower interobserver variability than other quantitative PET parameters (36), SUV peak could also has been used, as suggested by Wahl and colleagues (37). Indeed, SUV peak is less sensitive than SUV max to the image noise and voxel size (38). However, the region of interest (ROI peak ) used to measure SUV peak is not uniquely defined (39,40).…”
Section: Biologic Biomarkers Of Tumor Responsementioning
confidence: 99%
“…Because SUV max and SUV peak have both demonstrated lower interobserver variability than other quantitative PET parameters (36), SUV peak could also has been used, as suggested by Wahl and colleagues (37). Indeed, SUV peak is less sensitive than SUV max to the image noise and voxel size (38). However, the region of interest (ROI peak ) used to measure SUV peak is not uniquely defined (39,40).…”
Section: Biologic Biomarkers Of Tumor Responsementioning
confidence: 99%
“…It was a predictable consequence, because SUVmax would be more expected to reflect the metabolic status of the tumor than SUVmean [33].…”
Section: Discussionmentioning
confidence: 99%
“…Because SUVmax is determined by a single pixel with the highest SUV [43], it could also be effected by its [33] reported that SUVmax was much more biased by noise properties than multi-pixel summarized SUV. In the current study, the PET images were acquired for 3.5 min for each bed, and therefore, the average positive biases of SUVmax and SUVmean are expected to be about 10 and 5 %, respectively.…”
Section: Discussionmentioning
confidence: 99%
“…Consequently, SUV max has become the de facto standard for quantitative assessment of tracer uptake. Despite the reported upward bias in SUV max [24,25], which becomes even more pronounced with new PET technologies ( Supplementary Fig. 1 in [22]), it has some attractive features.…”
mentioning
confidence: 99%
“…SUV peak is based on a spherical volume of interest having a volume of ∼1 ml, positioned over the lesion such to obtain the highest average value. By averaging over 1 ml volume the upward bias as a function of image noise seen with SUV max may be avoided [25]. At the same time SUV peak may be less sensitive to underlying image characteristics as the dimensions of the peak volume of interest act as a smoothing filter [25].…”
mentioning
confidence: 99%