Noise-induced time-dependent changes in oxidative stress in the mouse cochlea and attenuation by d-methionine

Samson, J.; Wiktorek-Smagur, Aneta; Politański, Piotr; Rajkowska, Elżbieta; Pawlaczyk-Łuszczyńska, Małgorzata; Dudarewicz, Adam; Sha, Su Hua; Schacht, Jochen; Śliwińska-Kowalska, Mariola

doi:10.1016/j.neuroscience.2007.11.015

Cited by 65 publications

(68 citation statements)

References 20 publications

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“…Our results well correspond with other works in this field. Noise-induced threshold shifts [6], increased LPO levels [1,2] and alterations in enzyme activities [3] were also observed by other authors. The resultant data confirmed our hypothesis that SMF alters noise-induced oxidative processes in mouse cochlea.…”

Section: Figsupporting

confidence: 81%

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Static magnetic field affects oxidative stress in mouse cochlea

Politański¹,

Rajkowska²,

Pawlaczyk-Łuszczyńska³

et al. 2010

International Journal of Occupational Medicine and Environmental Health

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Objective: It has been shown that oxidative stress plays an important role in development of noise induced hearing loss. Since static magnetic fields (SMF) exposure may alter dynamics of oxidative processes in the tissue, the aim of the study was to assess the influence of SMF on noise-induced alteration in the cochlear level of reactive oxygen species (ROS) and hearing thresholds. Materials and Methods: Auditory brainstem response (ABR), lipid peroxidation (LPO) levels, superoxide dismutase (SOD) activity and catalase activity were assessed in the cochlea prior to, and at five time-points over two weeks following exposure of C57BL/6 mice to 8h, 119 dB SPL, 4kHz octave band noise. Results: The ABR indicated no permanent functional damage due to noise exposure either for the 4 kHz and 8 kHz SMF-exposed group or for animals not exposed to SMF. However, significant differences in LPO level, catalase and SOD activity between animals exposed to noise and SMF and those exposed to noise only were observed. Conclusions: The results suggest that SMF causes an increase in ROS level in the cochlea after noise exposure and, at the same time, it speeds up activation of antioxidative enzymes.

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Section: Figsupporting

confidence: 81%

“…The maximal levels of reactive oxygen species (ROS) in the cochlea are observed 7-10 days after noise exposure [1,2]. One of several theories explaining this delay is based on the deficiency of ROS scavenging enzymes after initial noise exposure [3].…”

Section: Introductionmentioning

confidence: 99%

Static magnetic field affects oxidative stress in mouse cochlea

Politański¹,

Rajkowska²,

Pawlaczyk-Łuszczyńska³

et al. 2010

International Journal of Occupational Medicine and Environmental Health

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“…These enzymes have been studied by several researchers to see the changes after noise-induced hearing loss. In an experimental study, 23 Samson et al measured SOD and CAT activities in cochlea from C57BL/6 mice 1-21 days after noise exposure and found increase in SOD activity without a concomitant increase in CAT activity. Antioxidant enzyme polymorphisms were studied in noise-induced hearing loss to see whether susceptibility to noise-induced hearing loss is associated with antioxidant enzymes.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

Pınar¹,

Atlı²,

Alaçam³

et al. 2011

UHOD

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Reactive oxygen and nitrogen species have been implicated in the pathogenesis of noise-induced hearing loss. In this case-control study, we investigated the oxidative and antioxidative status of erythrocytes from workers in noisy workplace. Blood samples of 127 workers in noisy workplace (WNW) and 117 workers in non-noisy workplace (WNNW) from the same company were taken into tubes with potassium EDTA as anticoagulant in order to obtain hemolysate. Total superoxide dismutase (SOD) and catalase (CAT) activities as the enzymes of antioxidative defense mechanism in the erythrocytes together with malondialdehyde (MDA) as the lipid peroxidation index and total nitric oxide (NO) as an index for nitrogen species analyses were performed by spectrophotometric methods. SOD activity was found to be 450.0±106.4 U/g Hb in WNW and 443.1±83.1 U/g Hb in WNNW. The difference between two groups were not statistically significant (p= 0.582). CAT activity was found to be 426.0±98.0 k/g Hb in WNW and 432.6±109.0 k/g Hb in WNNW showing statistically insignificant difference (p= 0.621). MDA levels in erythrocytes from WNW was significantly higher than WNNW (39.28±10.22 nmol/g Hb and 32.51±10.73 nmol/g Hb, respectively and p= 0.0001). On the other hand, NO levels were found to be significantly reduced in WNW (0.275±0.187 µmol/g Hb) compared to WNNW (0.382±0.284 µmol/g Hb) (p= 0.001). When we analyzed the hematological parameters, all the cell counts increased in WNW except monocytes and platelets compared to WNNW (p= 0.0001). Related to this changes, hemoglobin, MCHC, and hematocrit also increased in WNW (p= 0.0001). The oxidative stress, which is possibly propagated by the physical environment, seems to have an important pathophysiological role in hearing loss and lipid peroxidative cellular changes in all of the workers who work in noisy occupations.Key words: Noise, Worker, Oxidative stress, Superoxide dismutase, Catalase, Malondialdehyde, Nitric oxide ÖZET Gürültünün ‹nsan Eritrositlerindeki Oksidan ve Antioksidan Dengeye EtkileriReaktif oksijen ve nitrojen türleri, yüksek ses kaynakl› duyma kay›plar›nda önemli bir patolojik faktör olarak kabul görmekte-dir. Bu vaka kontrollü çal›flmam›zda yüksek sesli ortamlarda çal›flan iflçilerin eritrositlerinde oksidan ve antioksidan dengeyi araflt›rd›k. Yüksek sesli ortamda çal›flan (YSOÇ) 127 iflçi ile normal ortamda çal›flan (NOÇ) 117 iflçinin kanlar› hemolizat elde etmek üzere içinde antikoagulan olarak potasyum EDTA bulunan tüplere al›nd›.

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“…For example, Sampson and colleagues demonstrated that 400 mg/kg IP dosing of D -methionine was able to reverse noise-induced (4 kHz OBN; 100 dB SPL) oxidative stress in the mouse cochlea (measured as lipid peroxidase, SOD, and catalase activity) (Samson et al 2008 ). Over many years, Campbell and colleagues have exhaustively detailed the protective role of D -methionine in the inner ear.…”

Section: Nihl and Antioxidantsmentioning

confidence: 99%