Noise Removal From Microarray Images Using Maximum a Posteriori Based Bivariate Estimator

Abstract

Abstract-Microarray Image contains information about thousands of genes in an organism and these images are affected by several types of noises. They affect the circular edges of spots and thus degrade the image quality. Hence noise removal is the first step of cDNA microarray image analysis for obtaining gene expression level and identifying the infected cells. The Dual Tree Complex Wavelet Transform (DT-CWT) is preferred for denoising microarray images due to its properties like improved directional selectivity and near shift-invariance. In this paper, bivariate estimators namely Linear Minimum Mean Squared Error (LMMSE) and Maximum A Posteriori (MAP) derived by applying DT-CWT are used for denoising microarray images. Experimental results show that MAP based denoising method outperforms existing denoising techniques for microarray images.