Within the second-order non-Markovian master equation description, we develop an efficient method for calculating the noise spectrum of transport current through interacting mesoscopic systems. By introducing proper current-related density operators, we propose a practical and very efficient time-local approach to compute the noise spectrum, including the asymmetric spectrum, which contains the full information of energy emission and absorption. We obtain an analytical formula of the current noise spectrum to characterize the nonequilibrium transport including electron-electron Coulomb interaction and the memory effect. We demonstrate the proposed method in transport through interacting-quantum-dots system, and find good agreement with the exact results under broad range of parameters.