Noise trauma impairs neurogenesis in the rat hippocampus

Kraus, Kari Suzanne; Mitra, Sucharita; Jimenez, Zarina; Hinduja, Sneha; Ding, Dalian; Jiang, Haiyan; Gray, L.; Lobariñas, Edward; Sun, Wei; Salvi, Richard

doi:10.1016/j.neuroscience.2010.02.071

Cited by 162 publications

(161 citation statements)

References 86 publications

(95 reference statements)

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“…As shown in Figure 2, the overall fluctuations of (G + S)/S ratios were not significantly different (F(4,50)=0.14, p=0.966) when measured at different time points. Consistent with other studies, our control group of mice exhibit robust gap-induced inhibition of the startle response (Turner et al 2006;Yang et al 2007;Wang et al 2009;Kraus et al 2010). …”

Section: Gap Detection Performance In the Control Micesupporting

confidence: 91%

“…Previous studies have shown that acoustic trauma can induce tinnitus symptoms in 56% (Kraus et al 2010) to 75% (Wang et al 2009) of exposed rats. There are three possible factors that may contribute to this inconsistency.…”

Section: Figmentioning

confidence: 96%

“…For the gap detection test, parameters of our stimulus paradigm were set to levels which are typical for assuring a robust ∼30% reduction in startle response amplitude caused by a preceding gap of silence in an otherwise continuous background sound (Ison et al 2002;Turner et al 2006;Kraus et al 2010).…”

Section: Gap Detection Testingmentioning

confidence: 99%

“…Third, the type of anesthesia employed can also be critical for determining the outcome of sound exposure. Kraus et al (2010) reported that after a 2-h exposure to very loud sound (126 dB SPL), only 56% of rats developed behavioral signs of tinnitus. Another study, which was also conducted on rats, reported that just 1 h of only 116 dB SPL sound exposure produced tinnitus symptoms in 75% of exposed rats (Wang et al 2009).…”

Section: Figmentioning

confidence: 99%

“…Animals with behavioral evidence of tinnitus cannot detect silence and therefore their reduction of the startle reflex is significantly less than in normal animals. This method has been used successfully to assess tinnitus induced by salicylate overdose or acoustic trauma in rats (Turner et al 2006;Yang et al 2007;Kraus et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Development of Tinnitus in CBA/CaJ Mice Following Sound Exposure

Longenecker

Galazyuk

2011

JARO

109

140

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Tinnitus, the perception of a sound without an external acoustic source, is a complex perceptual phenomenon affecting the quality of life in 17% of the adult population. Despite its ubiquity and morbidity, the pathophysiology of tinnitus is a work in progress, and there is no generally accepted cure or treatment. Development of a reliable common animal model is crucial for tinnitus research and may advance this field. The goal of this study was to develop a tinnitus mouse model. Tinnitus was induced in an experimental group of mice by an exposure to a loud (116 dB sound pressure level (SPL)) narrow band noise (one octave, centered at 16 kHz) during 1 h under anesthesia. The tinnitus was then assessed behaviorally by measuring gap induced suppression of the acoustic startle reflex. We found that a vast majority of the sound-exposed mice (86%) developed behavioral signs of tinnitus. This was a complex, long lasting, and dynamic process. On the day following exposure, all mice demonstrated signs of acute tinnitus over the entire range of sound frequencies used for testing (10-31 kHz). However, 2-3 months later, a behavioral evidence of tinnitus was evident only at a narrow frequency range (20-31 kHz) representing a presumed chronic condition. Extracellular recordings confirmed a significantly higher rate of spontaneous activity in inferior colliculus neurons in sound-exposed compared to control mice. Surprisingly, unilateral sound exposure suppresses startle responses in mice and they remained suppressed even 3 months post-exposure, whereas auditory brainstem response thresholds were completely recovered during 2 months following exposure. In summary, behavioral evidence of tinnitus can be reliably developed in mice by sound exposure, and tinnitus induction can be assessed by quantifying prepulse inhibition of the acoustic startle reflex.

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Section: Gap Detection Performance In the Control Micesupporting

confidence: 91%

Section: Figmentioning

confidence: 96%

Section: Gap Detection Testingmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Development of Tinnitus in CBA/CaJ Mice Following Sound Exposure

Longenecker

Galazyuk

2011

JARO

109

140

View full text Add to dashboard Cite

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Noise‐induced hippocampal oxidative imbalance and aminoacidergic neurotransmitters alterations in developing male rats: Influence of enriched environment during adolescence

Molina

Buján

Guelman

2021

Developmental Neurobiology

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Living in big cities might involuntarily expose people to high levels of noise causing auditory and/or extra‐auditory impairments, including adverse effects on central nervous system (CNS) areas such as the hippocampus. In particular, CNS development is a very complex process that can be altered by environmental stimuli. We have previously shown that noise exposure of developing rats can induce hippocampal‐related behavioral alterations. However, noise‐induced biochemical alterations had not been studied yet. Thus, the aim of this work was to assess whether early noise exposure can affect rat hippocampal oxidative state and aminoacidergic neurotransmission tone. Additionally, the effectiveness of an enriched environment (EE) as a neuroprotective strategy was evaluated. Male Wistar rats were exposed to different noise schemes at 7 or 15 days after birth. Upon weaning, some animals were transferred to an EE whereas others were kept in standard cages. Short‐ and long‐term measurements were performed to evaluate reactive oxygen species, thioredoxins levels and catalase activity as indicators of hippocampal oxidative status as well as glutamic acid decarboxylase and a subtype of glutamate transporter to evaluate aminoacidergic neurotransmission tone. Results showed noise‐induced changes in hippocampal oxidative state and aminoacidergic neurotransmission markers that lasted until adolescence and differed according to the scheme and the age of exposure. Finally, EE housing was effective in preventing some of these changes. These findings suggest that CNS development seems to be sensitive to the effects of stressors such as noise, as well as those of an environmental stimulation, favoring prompt and lasting molecular changes.

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Neural correlates of tinnitus duration and Distress: A positron emission tomography study

Schecklmann

Landgrebe

Poeppl

et al. 2011

Human Brain Mapping

134

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Cerebral (18)F-deoxyglucose positron emission tomography (FDG-PET) has shown altered auditory pathway activity in tinnitus. However, the corresponding studies involved only small samples and analyses were restricted to the auditory cortex in most studies. Evidence is growing that also limbic, frontal, and parietal areas are involved in the pathophysiology of chronic tinnitus. These regions are considered to mediate perceptual, attentional, and emotional processes. Thus, the aim of the present study was the systematic evaluation of metabolic brain activity in a large sample of tinnitus patients. Ninety one patients with chronic tinnitus underwent FDG-PET. The effects of tinnitus severity (assessed by a tinnitus questionnaire score), duration and laterality were evaluated with statistical parametric mapping (SPM) in whole brain analyses. In addition, region of interest analyses were performed for primary auditory areas. Tinnitus duration correlated positively with brain metabolism in right inferior frontal, right ventro-medial prefrontal, and right posterior cingulate cortex. Tinnitus distress correlated positively with activation of left and right posterior inferior temporal gyrus as well as left and right posterior parahippocampal-hippocampal interface. Region of interest analysis demonstrated an overactivation of left in contrast to right Heschl's gyrus independently from tinnitus laterality and anatomical hemispheric differences. Tinnitus duration and distress were associated with areas involved in attentional and emotional processing. This is in line with recent findings indicating the relevance of higher order areas in the pathophysiology of tinnitus. Earlier results of asymmetric activation of the auditory cortices in tinnitus were confirmed, i.e., left-sided overactivation was found independently from tinnitus laterality.

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Noise trauma impairs neurogenesis in the rat hippocampus

Cited by 162 publications

References 86 publications

Development of Tinnitus in CBA/CaJ Mice Following Sound Exposure

Development of Tinnitus in CBA/CaJ Mice Following Sound Exposure

Noise‐induced hippocampal oxidative imbalance and aminoacidergic neurotransmitters alterations in developing male rats: Influence of enriched environment during adolescence

Neural correlates of tinnitus duration and Distress: A positron emission tomography study

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