Nomenclature for Factors of the HLA System, Update January 2008

Marsh, Steven G.E.

doi:10.1016/j.humimm.2008.04.001

Cited by 1 publication

(2 citation statements)

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“…The frequencies found for the HLA class II alleles either by serological or molecular methods are shown in Table 3. From the HLA‐DRB1 alleles classified by the molecular approach, 21 HLA‐DRB1*01 was the most prevalent (11%, 10/88) and was significantly more prevalent in male patients than in female patients, (40%, 4/10 and 8%, 3/38, respectively) (OR = 7.78, 95% CI 1.38–43.85). With respect to the HLA class II alleles by serological classification, 20 male patients showed a more prevalent HLA DR1 group compared to female patients (50%, 4/8 and 15%, 6/40, respectively) (OR = 5.67, 95% CI 1.10–29.11).…”

Section: Resultsmentioning

confidence: 99%

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Autoantibodies, Polymorphisms in the Serotonin Pathway, and Human Leukocyte Antigen Class II Alleles in Chronic Fatigue Syndrome

Ortega-Hernandez

Cuccia

Beigrezaei

et al. 2009

Annals of the New York Academy of Sciences

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This study aimed to determine the influence of autoantibodies, polymorphisms in the serotonin pathway, and human leukocyte antigen (HLA) class II genes on age at chronic fatigue syndrome (CFS) onset and symptoms. Eighty-one CFS patients were enrolled, and clinical data were recorded. Autoantibodies to different components of the central nervous system were tested. Polymorphisms in the promoter of the serotonin transporter gene (l/s) and a single nucleotide polymorphism in the serotonin receptor-2A gene (A/G) as well as HLA class II alleles were determined. Multivariate logistic-regression analyses were carried out. The mean age at CFS onset +/- SD was 33.5 +/- 12.5 years. An age at CFS onset (ACFSO) during the third decade of life was associated with the serotonin receptor AA genotype and the HLA-DRB1*03 allele. An ACFSO during the fourth decade of life was associated with the HLA-DRB1*07 allele, whereas an ACFSO > or = 43 years was associated with having at least one copy of the serotonin G allele. Concerning CFS symptoms, the serotonin AG genotype was protective against depressive symptoms. Although having at least one copy of the serotonin A allele and being female were associated with risk for arthralgia, the presence of antineuronal cell antibodies was protective against this. Episodes of unexplained fever were associated with the HLA-DRB1*11 allele. None of the genetic or serological features was associated with myalgia. None of the antibodies determined correlated with any ACFSO or other symptoms. Our results reveal that in CFS, like other autoimmune diseases, different genetic features are related to age at CFS onset and symptoms.

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Section: Resultsmentioning

confidence: 99%

“…The assay was run according to the manufacturer's instructions. We also classified HLA class II alleles using the old serological classification 20 in order to test if there were any additional differences that were not likely to be detected by means of the molecular approach 21 …”

Section: Methodsmentioning

confidence: 99%