Nomenclature for factors of the HLA system, update March 2018

Marsh, Steven G.E.

doi:10.1016/j.humimm.2018.04.007

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…The name DPB1*700:01N was officially assigned by the WHO Nomenclature Committee for Factors of the HLA System in March 2018 1 . This confirmatory sequence of DPB1*700:01N was reported to the IPD‐IMGT/HLA Database 2 (submission number HWS10063631) in October 2021. This follows the agreed policy that, subject to conditions stated in the most recent Nomenclature Report, 3 names will be assigned to new sequences as they are identified.…”

Section: Figurementioning

confidence: 97%

A single nucleotide mutation in exon 3 produces the novel HLA‐DPB1700:01N* allele

Yang

Lin

2021

HLA

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Section: Figurementioning

confidence: 97%

A single nucleotide mutation in exon 3 produces the novel HLA‐DPB1700:01N* allele

Yang

Lin

2021

HLA

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“…The name A*11:280 has been officially assigned by the WHO Nomenclature Committee for Factors of the HLA System in March 2018 1 . The confirmatory sequences of A*11:280 was submitted to the IPD‐IMGT/HLA Database 2 in June 2020 (submission number HWS10059311).…”

Section: Figurementioning

confidence: 99%

Detection of the HLA‐A11:280* allele in a Taiwanese individual

Yang

Lin

2020

HLA

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Next-Generation Sequencing Based HLA Typing: Deciphering Immunogenetic Aspects of Sarcoidosis

Kishore

Petřek

2018

Front. Genet.

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Unraveling of the HLA-related immunogenetic basis of several immune disorders is complex due to the extensive HLA polymorphism and strong linkage-disequilibrium between HLA loci. A lack of in phase sequence information, a relative deficiency of high resolution genotyping including non-coding regions and ambiguous haplotype assignment make it difficult to compare findings across association studies and to attribute a causal role to specific HLA alleles/haplotypes in disease susceptibility and modification of disease phenotypes. Earlier, historical antibody and DNA-based methods of HLA typing, primarily of low resolution at antigen/alellic group levels, yielded “indicative” findings which were partially improved by high-resolution DNA-based typing. Only recently, next-generation sequencing (NGS) approaches based on deep-sequencing of the complete HLA genes combined with bioinformatics tools began to provide the access to complete information at an allelic level. Analyzing HLA with NGS approaches, therefore, promises to provide further insight in the etiopathogenesis of several immune disorders in which HLA associations have been implicated. These range from coeliac disease and rheumatological conditions to even more complex disorders, such as type-1 diabetes, systemic lupus erythematosus and sarcoidosis. A systemic disease of unknown etiology, sarcoidosis has previously been associated with numerous HLA variants and also other gene polymorphisms, often in linkage with the HLA region. To date, the biological significance of these associations has only partially been defined. Therefore, more precise assignments of HLA alleles/haplotypes using NGS approaches could help to elucidate the exact role of HLA variation in the multifaceted etiopathogenesis of sarcoidosis, including epigenetic mechanisms. NGS-based HLA analyses may be also relevant for defining variable clinical phenotypes and for predicting the disease course or the response to current/plausible novel therapies.

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Nomenclature for factors of the HLA system, update March 2018

Cited by 3 publications

References 18 publications

A single nucleotide mutation in exon 3 produces the novel HLA‐DPB1700:01N* allele

A single nucleotide mutation in exon 3 produces the novel HLA‐DPB1700:01N* allele

Detection of the HLA‐A11:280* allele in a Taiwanese individual

Next-Generation Sequencing Based HLA Typing: Deciphering Immunogenetic Aspects of Sarcoidosis

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Nomenclature for factors of the HLA system, update March 2018

Cited by 3 publications

References 18 publications

A single nucleotide mutation in exon 3 produces the novel HLA‐DPB1*700:01N allele

A single nucleotide mutation in exon 3 produces the novel HLA‐DPB1*700:01N allele

Detection of the HLA‐A*11:280 allele in a Taiwanese individual

Next-Generation Sequencing Based HLA Typing: Deciphering Immunogenetic Aspects of Sarcoidosis

Contact Info

Product

Resources

About

A single nucleotide mutation in exon 3 produces the novel HLA‐DPB1700:01N* allele

A single nucleotide mutation in exon 3 produces the novel HLA‐DPB1700:01N* allele

Detection of the HLA‐A11:280* allele in a Taiwanese individual