Nomenclature for factors of the dog major histocompatibility system (DLA), 2000: Second report of the ISAG DLA Nomenclature Committee

Kennedy, L. J.; Angles, J. M.; Barnes, A.; Carter, Stuart; Francino, Olga; Gerlach, John; Happ, George M.; Ollier, William; Thomson, Wendy; Wagner, John L.

doi:10.1034/j.1399-0039.2001.580111.x

Cited by 53 publications

(61 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For some species or related species groups, such as the bovines, nonhuman primates, and dog, there have been efforts to use a standardized nomenclature system, and establish comprehensive datasets [Davies et al, 1994;Kennedy et al, 1999Kennedy et al, , 2001Klein et al, 1990]. The availability of these datasets for use by other groups has often been limited by a lack of informatics resources available to the researchers compiling the datasets.…”

Section: Ipd-mhcmentioning

confidence: 99%

The IMGT/HLA and IPD databases

et al. 2006

View full text Add to dashboard Cite

For the Immunogenetics Special IssueThe IMGT/HLA database (www.ebi.ac.uk/imgt/hla) has provided a centralized repository for the sequences of the alleles named by the WHO Nomenclature Committee for Factors of the HLA System since 1998. Since its initial release, the database has rapidly grown in size and is recognized as the primary source of information for the study of sequences of the human major histocompatibility complex. The Immuno Polymorphism Database (IPD; www.ebi.ac.uk/ipd) is a set of specialist databases related to the study of polymorphic genes in the immune system. The IPD currently consists of four databases: IPD-KIR contains the allelic sequences of killercell immunoglobulin-like receptors; IPD-MHC is a database of sequences of the major histocompatibility complex of different species; IPD-HPA contains alloantigens expressed only on platelets (human platelet antigens or HPA); and IPD-ESTDAB provides access to the European Searchable Tumour Cell-Line Database, a cell bank of immunologically characterized melanoma cell lines.

show abstract

Section: Ipd-mhcmentioning

confidence: 99%

The IMGT/HLA and IPD databases

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Differences in intensity of selection at these loci have also been reported for humans (Salamon et al 1999;Satta et al 1994), northern elephant seals (Mirounga angustirostris- Weber et al 2004), cotton-top tamarins (Saguinus oedipus- Gyllensten et al 1994), wolves (Canis lupus- Seddon and Ellegren 2002), and dogs (Canis lupus familiaris- Kennedy et al 2000Kennedy et al , 2001; in each case, allelic variability was greater for DRB. Intensity of selection also tended to be greater for DRB, particularly for humans (Satta et al 1994), suggesting a consistent, perhaps functional basis for differences in variability between these loci.…”

Section: Discussionmentioning

confidence: 78%

Major Histocompatibility Complex Variation in Talas Tuco-Tucos: The Influence of Demography on Selection

Cutrera¹,

Lacey²

2006

Journal of Mammalogy

View full text Add to dashboard Cite

“… (A) Alignment of MHC class I α1 and α2 domain amino acid sequences of human (HLA-A*02:01; AAA76608.2 a ) and dog (DLA-88*50101; AF100577, AF101496, [19] b ). Identity of amino acid sequences to human HLA-A*02:01 is shown by dashes, disposability of data is illustrated by a dot.…”

Section: Resultsmentioning

confidence: 99%

“…For the comparison of DLA-88*50101 and HLA-A*02:01 amino acid sequences, as well as certain residues within the binding pockets, the following reference sequences were used: HLA-A*02:01 (AAA76608.2, [39–41]) and DLA-88*50101 (AF100577, AF101496, [19]). The binding motif of HLA-A*02:01 was previously published [42, 43] and the web illustration at NetMHC-4.0 Server was modified by S. Barth.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of the Canine MHC Class I DLA-88*50101 Peptide Binding Motif as a Prerequisite for Canine T Cell Immunotherapy

et al. 2016

View full text Add to dashboard Cite

There are limitations in pre-clinical settings using mice as a basis for clinical development in humans. In cancer, similarities exist between humans and dogs; thus, the dog patient can be a link in the transition from laboratory research on mouse models to clinical trials in humans. Knowledge of the peptides presented on MHC molecules is fundamental for the development of highly specific T cell-based immunotherapies. This information is available for human MHC molecules but is absent for the canine MHC. In the present study, we characterized the binding motif of dog leukocyte antigen (DLA) class I allele DLA-88*50101, using human C1R and K562 transfected cells expressing the DLA-88*50101 heavy chain. MHC class I immunoaffinity-purification revealed 3720 DLA-88*50101 derived peptides, which enabled the determination of major anchor positions. The characterized binding motif of DLA-88*50101 was similar to HLA-A*02:01. Peptide binding analyses on HLA-A*02:01 and DLA-88*50101 via flow cytometry showed weak binding of DLA-88*50101 derived peptides to HLA-A*02:01, and vice versa. Our results present for the first time a detailed peptide binding motif of the canine MHC class I allelic product DLA-88*50101. These data support the goal of establishing dogs as a suitable animal model for the evaluation and development of T cell-based cancer immunotherapies, benefiting both dog and human patients.

show abstract

Nomenclature for factors of the dog major histocompatibility system (DLA), 2000: Second report of the ISAG DLA Nomenclature Committee

Abstract: Abstract:The ISAG DLA Nomenclature Committee met during the ''Comparative Evolution of the Mammalian MHC'' meeting in Manchester, England on 10th September 2000. The main points discussed were the naming of class I genes and alleles, and the inclusion of alleles from other canidae.

Cited by 53 publications

References 25 publications

The IMGT/HLA and IPD databases

The IMGT/HLA and IPD databases

Major Histocompatibility Complex Variation in Talas Tuco-Tucos: The Influence of Demography on Selection

Characterization of the Canine MHC Class I DLA-88*50101 Peptide Binding Motif as a Prerequisite for Canine T Cell Immunotherapy

Contact Info

Product

Resources

About