Nomenclature for factors of the HLA system, update October, November and December 2023

Abstract

ture update (Marsh, 2023) and, following agreed policy, have been assigned official allele designations (Marsh et al., 2010). Full details of all sequences will be published in a forthcoming report.Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given, and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries.Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case, you will have to contact the submitting author directly.Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publica-tions that describe new human leucocyte antigen (HLA) sequences is given in Table 3. An additional 105 alleles were recently published but have not been included in Table 3 due to space considerations (Alizadeh et al., 2024;Cambridge et al., 2024). In addition, the allele DRB1*07:147Q has had a suffix change and has been renamed DRB1*07:147N. Furthermore, the sequence for the allele DRA*01:02:02:18 was shown to be in error and is identical to DRA*01:02:01:01. The name DRA*01:02:02:18 has been deleted. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IPD-IMGT/HLA Database using the sequence submission tool provided (Barker et al., 2023). The IPD-IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ipd/imgt/ hla.