Nomenclature for factors of the HLA system, update February 2009

Marsh, Steven G.E.

doi:10.1111/j.1399-0039.2009.01285.x

Tissue Antigens

2009

DOI: 10.1111/j.1399-0039.2009.01285.x

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Nomenclature for factors of the HLA system, update February 2009

Steven G.E. Marsh

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“…All new sequences were reported to the IMGT/HLA Database and named by the World Health Organization (WHO) Nomenclature Committee. These newly named alleles were then included in the monthly HLA nomenclature updates between February 2009 3 and March 2013 4 .…”

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Identification of 2127 new HLA class I alleles in potential stem cell donors from Germany, the United States and Poland

et al. 2014

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We describe 2127 new human leukocyte antigen (HLA) class I alleles found in registered stem cell donors. These alleles represent 28.9% of the currently known class I alleles. Comparing new allele sequences to homologous sequences, we found 68.1% nonsynonymous nucleotide substitutions, 28.9% silent mutations and 3.0% nonsense mutations. Many substitutions occurred at positions that have not been known to be polymorphic before. A large number of HLA alleles and nucleotide variations underline the extreme diversity of the HLA system. Strikingly, 156 new alleles were found not only multiple times, but also in carriers of various parentage, suggesting that some new alleles are not necessarily rare. Moreover, new alleles were found especially often in minority donors. This emphasizes the benefits of specifically recruiting such groups of individuals.

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Identification of 2127 new HLA class I alleles in potential stem cell donors from Germany, the United States and Poland

et al. 2014

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Nomenclature for factors of the HLA system, update February 2009

Cited by 1 publication

References 8 publications

Identification of 2127 new HLA class I alleles in potential stem cell donors from Germany, the United States and Poland

Identification of 2127 new HLA class I alleles in potential stem cell donors from Germany, the United States and Poland

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