Nomenclature of flavonoids (IUPAC Recommendations 2017)

Rauter, Amélia P.; Ennis, Marcus; Hellwich, Karl‐Heinz; Herold, Bernardo J.; Horton, Derek; Moss, G. P.; Schomburg, Ida

doi:10.1515/pac-2013-0919

Cited by 56 publications

(37 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Flavonoids are the largest class of polyphenols followed by phenolic acids in alliums, while lignans are a minor polyphenol class [17]. Flavonoids have a characteristic 15-carbon (C6-C3-C6) skeleton, which consists of two phenyl rings (A and B) and a heterocyclic ring (C) [18,19]. They are classified into different subclasses (flavonols, flavanols, flavanones, flavones, anthocyanins, and isoflavones) based on the degree of unsaturation and oxidation of the C-ring.…”

Section: Flavonoids In Allium: Structural Propertiesmentioning

confidence: 99%

“…They are classified into different subclasses (flavonols, flavanols, flavanones, flavones, anthocyanins, and isoflavones) based on the degree of unsaturation and oxidation of the C-ring. Among different subclasses, further division is based on the number and nature of substituent groups attached to their heterocyclic rings [18,19]. Flavonols and anthocyanins are the main subclasses of flavonoids present in alliums, though the latter have been found only in red onions [20,21].…”

Section: Flavonoids In Allium: Structural Propertiesmentioning

confidence: 99%

“…Flavonols, the most abundant class of flavonoids in alliums [22][23][24], contain a 3-hydroxyflavone backbone (IUPAC name: 3-hydroxy-2-phenylchromen-4-one) [18,19]. Their diversity arises from the different positions of the phenolic -OH groups.…”

Section: Flavonolsmentioning

confidence: 99%

See 2 more Smart Citations

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

2020

View full text Add to dashboard Cite

Allium species are revered worldwide as vegetables, condiments, and spices as well as the therapeutic agents in traditional medicine. The bioactive compounds in alliums mainly include organosulfur compounds, polyphenols, dietary fibers, and saponins. Flavonoids, particularly flavonols from alliums, have been demonstrated to have the antioxidant, anticancer, hypolipidemic, anti-diabetic, cardioprotective, neuroprotective, and antimicrobial activities. However, flavonols are mostly characterized from onions and have not been comprehensively reviewed across different species. This article therefore focuses on flavonol profiles from different Allium species, their health effects, underlying molecular mechanisms, and bioavailability. Intriguingly, the functional health effects of flavonols were mainly ascribed to their antioxidant and anti-inflammatory activities involving a cascade of multiple signaling pathways. Although the Allium-derived flavonols offer tremendous potential in preventing chronic disease risks, in-depth studies are needed to translate their clinical application.

show abstract

Section: Flavonoids In Allium: Structural Propertiesmentioning

confidence: 99%

Section: Flavonoids In Allium: Structural Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

2020

View full text Add to dashboard Cite

show abstract

“…Having a chemical structure similar to cholesterol and other steroids, flavonoids may influence the production of androgens in Leydig cells. Therefore, more than 500 publications have reported effects of different flavonoids on testosterone production since Based on the 2-Phenyl-3,4-dihydro-2H-1-benzopyran skeleton, there are four major groups of flavonoids (Figure 2a): flavans, flavones, flavonols, and anthocyanidins [22]. Isoflavonoids are divided into two main families (Figure 2b): isoflavans and isoflavones, both based on the 3-Phenyl-3,4-dihydro-2H-1-benzopyran skeleton [22].…”

Section: Flavonoids and Steroidogenesismentioning

confidence: 99%

Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism

Martin

Touaibia

2020

Antioxidants

View full text Add to dashboard Cite

Androgen production, being important for male fertility, is mainly accomplished by the Leydig cells from the interstitial compartment of the testis. Testosterone plays a critical role in testis development, normal masculinization, and the maintenance of spermatogenesis. Within seminiferous tubules, appropriate Sertoli cell function is highly dependent on testicular androgen levels and is essential to initiate and maintain spermatogenesis. During aging, testosterone production by the testicular Leydig cells declines from the 30s in humans at a rate of 1% per year. This review outlines the recent findings regarding the use of flavonoids and isoflavonoids to improve testosterone production, contributing to normal spermatogenesis and preventing age-related degenerative diseases associated with testosterone deficiency. With the cumulation of information on the actions of different flavonoids and isoflavonoids on steroidogenesis in Leydig cells, we can now draw conclusions regarding the structure-activity relationship on androgen production. Indeed, flavonoids having a 5,7-dihydroxychromen-4-one backbone tend to increase the expression of the steroidogenic acute regulatory protein (StAR), being critical for the entry of cholesterol into the mitochondria, leading to increased testosterone production from testis Leydig cells. Therefore, flavonoids and isoflavonoids such as chrysin, apigenin, luteolin, quercetin, and daidzein may be effective in delaying the initiation of late-onset hypogonadism associated with aging in males.

show abstract

“…The largest common class of polyphenols present in human diet is represented by flavonoids [2,3]. Chemically flavonoids are classified in flavans, flavones, flavonols, and anthocyanidins [4]. Among the flavonols, myricetin, a 3,3′,4′,5,5′,7-hexahydroxyflavone, possess one of the most hydroxylated structures (Fig.…”

Section: Introductionmentioning

confidence: 99%

Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications

Taheri

Suleria

Martins

et al. 2020

BMC Complement Med Ther

159

111

View full text Add to dashboard Cite

Several flavonoids have been recognized as nutraceuticals, and myricetin is a good example. Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. One of its beneficial biological effects is the neuroprotective activity, showing preclinical activities on Alzheimer, Parkinson, and Huntington diseases, and even in amyotrophic lateral sclerosis. Also, myricetin has revealed other biological activities, among them as antidiabetic, anticancer, immunomodulatory, cardiovascular, analgesic and antihypertensive. However, few clinical trials have been performed using myricetin as nutraceutical. Thus, this review provides new insights on myricetin preclinical pharmacological activities, and role in selected clinical trials.

show abstract

Nomenclature of flavonoids (IUPAC Recommendations 2017)

Cited by 56 publications

References 13 publications

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism

Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications

Contact Info

Product

Resources

About