Nomogram for deciding adjuvant treatment after surgery for oral cavity squamous cell carcinoma

Abstract

This preliminary nomogram is the first prognostic model developed and externally validated to predict the likelihood of LRFS after treatment for an individual patient with OCSCC and may have practical utility for deciding adjuvant treatment.

Are wider surgical margins needed for early oral tongue cancer?

“…4 However, the overall rate of involved margins in the USA has been estimated as 16 per cent, similar to that in our series. 10 In a review of 301 tumours, Woolgar and Triantafyllou found that 13 per cent had involved margins and a further 43 per cent had close margins, similar to our findings.…”

“…3 Although the former two factors have an impact on adjuvant treatment, the latter is the only factor that may be improved by the surgeon. 4 Traditionally, a 1-cm margin is taken in all planes around a macroscopic or palpable oral tongue SCC. 5 Pathologists and clinicians have agreed to define involved margins as less than 1 mm and close margins as 5 mm or less, while margins greater than 5 mm are designated as clear.…”

Nomograms for preoperative prediction of prognosis in patients with oral cavity squamous cell carcinoma

“…[9][10][11] We have previously reported on the use of a nomogram for postoperative management of patients with oral cancer, 12 and proposed the use of nomograms for staging of head and neck cancer. 3 With this study, we introduce the concept of using individualized risk prediction tools for estimating OS, cancer-specific mortality, and locoregional recurrence risk in individual patients undergoing surgery with or without radiation therapy for SCCOC.…”

Development and external validation of nomograms predictive of response to radiation therapy and overall survival in nasopharyngeal cancer patients

“…The utility of nomograms in addition to TNM staging system in individualised risk prediction has been well recognised in a variety of cancers [15,27,28]. In HNC, several studies reported the advantages of nomograms in predicting the prognosis and determining the treatment modality [18,29]. For example, in patients with unknown primary malignancy of the head and neck, a nomogram based on the location(s) of metastatic neck lymph node(s) could help reveal the occult primary site [30].…”

“…Several nomograms have been currently employed in oncology [11][12][13][14]. An advantage of nomogram over the conventional TNM system is the predictive power of the outcome of interest on an individual patient [15][16][17][18]. In addition, the model has a potential of incorporation into the current TNM staging system [19][20][21][22].…”