Nomogram for Predicting the Overall Survival of Adult Patients With Primary Gastrointestinal Diffuse Large B Cell Lymphoma: A SEER- Based Study

Abstract

Background: The aim of this study was to establish a precise prognostic model, based on significant clinical parameters, for predicting the overall survival (OS) of adult patients with primary gastrointestinal diffuse large B cell lymphoma (GI DLBCL). Materials and Methods: The data of 7,121 GI DLBCL patients, diagnosed between 1997 and 2015, were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. These patients were randomly divided into two sequential cohorts: training (n = 5,697) set and validation (n = 1,424) set. ROC methodology and calibration curves were explicitly used to evaluate the predictive performance of nomogram. Results: The median OS in the training cohort was 76 months (1-239 months), and 3, 5, and 10-year OS rates were 60.3, 53.9, and 39.5%, respectively. Age at diagnosis, Ann Arbor stage, and marital status were important clinical predictors of OS. These characteristics were used to build a nomogram. The AUC of the nomogram for predicting 3, 5, and 10-year OS were 0.669, 0.692, and 0.740, respectively. All RUC and calibration curves revealed good accuracy in predicting prognosis of GI DLBCL. Conclusion: In summary, the established nomogram was validated to predict OS for adult patients with GI DLBCL. This predictive model could help clinicians identify high-risk patients to improve their prognosis.

Role of radiation therapy in primary tonsil large B cell lymphoma: a SEER-based analysis

“…The nomogram was both internally and externally validated by measuring discrimination and calibration curves. As previously described [ 12 , 13 ], internal validation was carried out with bootstrap resamples, in which regression models were fitted in 1000 bootstrap replicates, drawn from the development sample. External validation was performed with the validation datasets.…”

Surgery and Chemotherapy versus Chemotherapy Only in Older Persons with Primary Intestinal Diffuse Large B-Cell Lymphoma

“…However, a large-scale retrospective study based on the SEER database showed that age, Ann Arbor stage and marital status were independent prognostic factors for OS. 22 The possible explanation for this discrepancy is that our sample size was small compared to that of the previous study. However, unlike the previous study, our study focused on elderly patients with PI-DLBCL and did not include patients with primary gastric DLBCL, resulting in the enrolment of fewer patients in the present study.…”

A nomogram model to predict the venous thromboembolism risk after surgery in patients with gynecological tumors

“…The nomogram is a useful and popular visual graph that illustrates the probability of occurrence of predicted events so as to guide clinical treatments [12][13][14]. Several past studies have reported that nomogram has good risk-prediction ability for post-surgical survival prognostication in patients with malignant tumors [15,16]. However, reports on the use of a nomogram model for predicting the risk of thrombosis are limited [17].…”