Nomograms Based on the Albumin/Neutrophil-to-Lymphocyte Ratio Score for Predicting Coronary Artery Disease or Subclinical Coronary Artery Disease

Abstract

Purpose To develop and validate two nomograms incorporating the albumin/neutrophil-to-lymphocyte ratio score (ANS) for predicting the risk of coronary artery disease (CAD) or subclinical CAD. Patients and Methods Four hundred fifty patients with suspected CAD who underwent coronary computed tomographic angiography were consecutively enrolled between September 2015 and June 2017. Nomograms were established based on independent predictors of CAD or subclinical CAD. Results In total, 437 patients with suspected CAD who underwent coronary computed tomographic angiography were included. Male sex, age ≥65 years, smoking, hypertension, diabetes, dyslipidemia, ischemic stroke, and ANS were independent predictors of CAD and subclinical CAD. The areas under the curve of each nomogram were 0.799 (95% CI: 0.752–0.846) and 0.809 (95% CI: 0.762–0.856), respectively. The calibration curve and decision curve analysis showed good performance for the diagnostic nomograms. The prediction of CAD or subclinical CAD by the ANS was not modified by the independent predictors (all, p for interaction >0.05). Conclusion Our ANS-based nomograms can provide accurate and individualized risk predictions for patients with suspected CAD or subclinical CAD.

Albumin combined with neutrophil-to-lymphocyte ratio score and outcomes in patients with acute coronary syndrome treated with percutaneous coronary intervention

“…Based on our previous study, we used the same method to determine the cutoff points for albumin and NLR were 4.07 g/dl and 2.60, respectively [ 18 ]. Kaplan–Meier analysis both before and after PSM indicated that the ANS was a powerful prognostic factor for the clinical outcomes of ACS patients undergoing PCI (Fig.…”

“…This is consistent with our previous research [ 19 ]. Concomitantly, the calculation methods of NLR and ANS are also the same as our previous studies [ 18 ]. The NLR was calculated using the following formula: NLR = neutrophil count (10 9 /l)/lymphocyte count (10 9 /l) [ 14 ].…”

“…Some studies have recently reported that albumin combined with neutrophil-to-lymphocyte ratio score (ANS) is valuable for prognosis of patients with colorectal cancer and patients who undergo mandibulofacial reconstruction with a fibula flap [ 16 , 17 ]. In our previous study, we found that albumin combined with NLR score was an independent risk factor of CAD [ 18 ]. To the authors’ knowledge, however, the prognostic value of the ANS for patients with ACS undergoing PCI has never been scrutinized explicitly.…”

Biomarker of severity in hospitalised patients with COVID-19: a retrospective study

“…Several studies have shown that the ANS can be used as an important predictor of disease and surgery. 33 These include pancreaticoduodenectomy, 23 vascularised fibular flap reconstruction, 24 coronary artery disease, subclinical coronary artery disease, 19 neck cancer 21 and rectal cancer. 20 Based on the current research, there is no indication that the ANS is linked to COVID-19.…”

“…Although serum albumin level and NLR are common biomarkers, they are easy to assess in clinical practice. However, an increasing number of studies have shown that the combination of serum albumin and NLR, as a serum albumin-NLR score (ANS), could have good prognostic value for coronary artery disease, 19 cancer 20 22 and postoperative complications. 23 24 Whether ANS could be used to measure the prognosis of COVID-19 is unclear, and this study hypothesised that ANS was a simple prognostic tool that could be used to the severity of patients with COVID-19.…”