Non-A, non-B, non-C hepatitis: Its significance in pediatric patients and the role of GB virus-C

Lai, Ming Yang; Chang, Mei–Hwei; Hsu, Hong‐Yuan

doi:10.1016/s0022-3476(97)70057-x

Cited by 12 publications

(10 citation statements)

References 26 publications

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“…1 Pediatric patients with NABC FH also have a longer interval preceding encephalopathy and death than those with FHB. 26 Because NABC FH has a high mortality rate and is resistant to intensive medical care, including artificial liver support, identifying its etiologic agents is imperative.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan

Ishikawa

Hasegawa

Naritomi

et al. 2002

Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 99%

Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan

Ishikawa

Hasegawa

Naritomi

et al. 2002

Journal of Gastroenterology

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“…In the children with non-A to E hepatitis, HBsAg was checked by RIA (Abbot Laboratories, North Chicago, IL) and anti-HCV was assayed by a commercially available second generation ELISA (Hepatitis C II; Abbott Laboratories). HCV RNA and HGV RNA were detected by RT-PCR, and serum anti-HEV was detected by EIA as those described previously [Ni et al, 1994;Chen et al, 1997;Lai et al, 1997].…”

Section: Subjectsmentioning

confidence: 99%

“…Without such information, the understanding of the natural history of TTV infection in children would be incomplete. A previous study also showed that non-A to E hepatitis plays an important role in the etiology of pediatric viral hepatitis and that the role of GBV-C (HGV) is minor [Lai et al, 1997]. Thus, a search for other unknown viral agents responsible for non-A to E hepatitis is needed.…”

Section: Introductionmentioning

confidence: 99%

TT virus infection in healthy children, children after blood transfusion, and children with non‐A to E hepatitis or other liver diseases in Taiwan

Hsu

Chen

et al. 2002

Journal of Medical Virology

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Serum samples from healthy and diseased children were studied for the presence of TTV DNA by nested PCR using primer sets generated from N-22 region and from the untranslated region (UTR) of the viral genome. N-22 positive TTV DNA was detectable in 33 (27%) of 122 healthy children, 47 (73.4%) of 64 polytransfused thalassemic children, 37 (46.3%) of 80 children who received transfusion during cardiac surgery, 8 (42.1%) of 19 non-A to E hepatitis, 10 (33.3%) of 30 HBV carrier children, and 5 (15.6%) of 32 infants with biliary atresia. A much higher prevalence of TTV DNA with rates varying from 78-100% in the above study groups was observed using the UTR primers. For children with N-22 positive TTV DNA, biochemical assessment of isolated TTV viremia in thalassemic children or children transfused during surgery showed no convincing association between raised ALT levels and TTV viremia. Coinfection with TTV in chronic HCV-infected or HBV-infected children did not result in higher peak ALT levels during follow-up, suggesting that TTV has no synergistic pathogenic effect. The phylogenetic analysis of the N-22 positive TTV DNA isolates revealed that most isolates from healthy children, children transfused during surgery, and non-A to E fulminant hepatitis children were type 1 TTV. These results indicate that TTV infection in children was significantly associated with transfusion. TTV infection is highly prevalent in early childhood in Taiwan but plays a minimal role in the induction of hepatitis in children.

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“…Although some studies have been conducted in children [Bortolotti et al, 1997;Chen et al, 1997;Chung et al, 1997;Lai et al, 1997;Lopez-Alcorocho et al, 1997;Mison et al, 1997;Szabo et al, 1998], little is known about the virological, serological, biochemical, and histological characteristics of GBV-C/HGV infection in children. In this retrospective study, we investigated the clinical, virological, and histological implications of a concomitant GBV-C/HGV infection in children with hepatitis C virus (HCV)-related liver disease.…”

mentioning

confidence: 99%

GBV-C/HGV infection in children with chronic hepatitis C

et al. 1999

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The role of GB virus-C/hepatitis G virus (GBV-C/HGV), a recently identified member of the Flaviviridae family, in children with liver disease is not well understood. The aims of this study were to evaluate the prevalence of GBV-C/HGV and to clarify its pathogenic role in young patients with chronic hepatitis C. Sixty-four Japanese children and adolescents with chronic hepatitis C virus (HCV) infection, with a mean age of 9.8 years, were evaluated retrospectively. Twenty-one (32.8%) of the 64 patients were positive for serum GBV-C/HGV RNA. Only 1 (1.6%) of the 64 patients was positive for antibody against the envelope protein E2 of GBV-C/HGV (anti-E2) and GBV-C/HGV. None of them was positive for anti-E2 alone. There was no significant difference in clinical, virological, or histological characteristics between GBV-C/HGV-positive and GBV-C/HGV-negative patients, except for underlying malignant disease. There was no evidence that GBV-C/HGV might affect the response of HCV to interferon therapy in young patients with chronic hepatitis C. The prevalence of GBV-C/HGV infection in young patients with chronic hepatitis C is similar to that in adult patients with chronic hepatitis C, but E2-seroconversion is observed infrequently. Underlying malignant disease is a risk factor for GBV-C/HGV viremia. GBV-C/HGV does not seem to affect the clinical course of young patients with chronic hepatitis C.

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Non-A, non-B, non-C hepatitis: Its significance in pediatric patients and the role of GB virus-C

Cited by 12 publications

References 26 publications

Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan

Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan

TT virus infection in healthy children, children after blood transfusion, and children with non‐A to E hepatitis or other liver diseases in Taiwan

GBV-C/HGV infection in children with chronic hepatitis C

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