Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk

Lee, William R.; Shen, Shing Chuan; Aljuffali, Ibrahim A.; Lin, Yin Ku; Huang, Chung-Huei; Fang, Jia You

doi:10.1016/j.ejps.2016.06.016

Cited by 21 publications

(15 citation statements)

References 47 publications

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“…However, studies are ongoing to assess the delivery of numerous substances with multiple laser modalities (Haedersdal et al, 2016, Zaleski-Larsen and Fabi, 2016). At least one recent study has shown the potential of nonablative fractional lasers to deliver small- and macro-molecules (Lee et al, 2016). The hope is that LADD may offer a more effective way to deliver medications especially for the dermal type of melasma for which topical delivery seems to be out of reach and has limited success.…”

Section: Overview Of Laser- and Light-based Treatment Optionsmentioning

confidence: 99%

A review of laser and light therapy in melasma

Trivedi

Yang

Cho³

2017

International Journal of Women's Dermatology

139

135

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Melasma is a dysregulation of the homeostatic mechanisms that control skin pigmentation and excess pigment is produced. Traditional treatment approaches with topical medications and chemical peels are commonly used but due to the refractory and recurrent nature of melasma, patients often seek alternative treatment strategies such as laser and light therapy. Several types of laser and light therapy have been studied in the treatment of melasma. Intense pulsed light, low fluence Q-switched lasers, and non-ablative fractionated lasers are the most common lasers and light treatments that are currently performed. They all appear effective but there is a high level of recurrence with time and some techniques are associated with an increased risk for postinflammatory hyper- or hypopigmentation. The number and frequency of treatments varies by device type but overall, Q-switched lasers require the greatest number of treatment applications to see a benefit. Vascular-specific lasers do not appear to be effective for the treatment of melasma. Ablative fractionated lasers should be used with caution because they have a very high risk for postinflammatory hypo- and hyperpigmentation. The use of nonablative fractionated laser treatments compared with other laser and light options may result in slightly longer remission intervals. Picosecond lasers, fractional radiofrequency, and laser-assisted drug delivery are promising future approaches to treat melasma. The goal of this review is to summarize the efficacy and safety of the most commonly used laser and light therapies to treat melasma, briefly present future laser-based treatment options for patients with melasma, and provide recommendations for treatment on the basis of the reviewed information.

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Section: Overview Of Laser- and Light-based Treatment Optionsmentioning

confidence: 99%

A review of laser and light therapy in melasma

Trivedi

Yang

Cho³

2017

International Journal of Women's Dermatology

139

135

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“…Kositratna et al showed rapid formation of fibrin plugs in fractional lesions which could influence drug uptake and potentially be controlled by properties of the coagulation zone . Lee et al presented that non‐ablative fractional laser treatments assist cutaneous delivery of small‐ and macro‐ molecules through the skin with minimal bacterial infection risk . Despite its common use for many indications, fractional laser treatments remain the risk of side‐effects, such as hyperpigmentation, redness and burning.…”

Section: Introductionmentioning

confidence: 99%

Assessment of skin lesions produced by focused, tunable, mid‐infrared chalcogenide laser radiation

Evers

Casper

et al. 2018

Lasers Surg Med

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The tunable laser system provides a useful research tool to investigate specific laser parameters such as wavelength on lesion shape, ablation depth and thermal tissue damage. It also allows for customization of the characteristics of laser lesions and therefore facilitates the selection of suitable laser parameters for optimized fractional laser treatments. Lasers Surg. Med. 50:961-972, 2018.© 2018 Wiley Periodicals, Inc.

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“…Cutaneous penetration of small-molecule drugs, macromolecules, and nano-particles can be facilitated. A non-ablative 1,550 nm Er-Glass fractional laser (Dinona, Sellas evo, Daejeon, Korea) was used by Lee, et al, as an instrument to enhance percutaneous drug absorption [6]. They used the fluence of 30 mJ with MTZ 100 μm, and spot densities 256 to 529 spots/cm 2 on the pigs and nude mice skin.…”

Section: Non-ablative Fractional Lasermentioning

confidence: 99%

The Applications of Fractional Lasers in Taiwan

Chen¹

2021

JDR

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The applications of fractional lasers are enormous. In Taiwan, the most commonly used fractional lasers can be divided into 3 different categories: ablative, non-ablative, and combined hybrid laser. The ablative fractional laser was invented as a new instrument to be used for facial resurfacing initially. On the contrary, the non-ablative fractional laser was introduced primarily to rejuvenate skin with minimal downtime. It produces dermal thermal damage without significantly affecting the overlying epidermal layers of the skin. Both the ablative and nonablative lasers are applied increasingly to various dermatological conditions. Herein, the author will review the researches and multiple applications of fractional lasers in Taiwan.

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Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk

Cited by 21 publications

References 47 publications

A review of laser and light therapy in melasma

A review of laser and light therapy in melasma

Assessment of skin lesions produced by focused, tunable, mid‐infrared chalcogenide laser radiation

The Applications of Fractional Lasers in Taiwan

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