Non-AIDS–Defining Cancers in New Orleans

Ruiz, Marco; Johnson, Daniel; Reske, Thomas; Cefalu, Charles A.; Estrada, Juan A.

doi:10.1177/2325957412471994

Cited by 3 publications

(2 citation statements)

References 36 publications

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“… 1 , 2 The advent and widespread availability of antiretroviral therapy (ART) has led to both a four-fold decrease in mortality due to AIDS and a three-fold decrease in AIDS-defining cancers (ADCs) worldwide. 3 - 6 At the same time, as the life expectancy and prevalence of women living with HIV increases, there has been a three-fold increase in the incidence of certain non-AIDS–defining cancers (NADCs), such as lung cancer, Hodgkin lymphoma, squamous cell carcinoma, testicular cancer, and esophageal cancer. 4 - 6 SSA has experienced similar trends, with a declining incidence of ADCs such as Kaposi sarcoma in Botswana and an increase in NADCs in Tanzania.…”

Section: Introductionmentioning

confidence: 99%

Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Grover

Martei

Puri

et al. 2018

JGO

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IntroductionThe number and lifespan of individuals living with HIV have increased significantly with the scale-up of antiretroviral therapy. Furthermore, the incidence of breast cancer in women with HIV is growing, especially in sub-Saharan Africa (SSA). However, the association between HIV infection and breast cancer is not well understood.MethodsA literature search was performed to identify articles published in journals pertaining to breast cancer and HIV, with an emphasis on SSA. Selected US-based studies were also identified for comparison.ResultsAmong the 56 studies reviewed, the largest study examined 314 patients with breast cancer and HIV in the United States. There is no consensus on whether HIV infection acts as a pro-oncogenic or antioncogenic factor in breast cancer, and it may have no relation to breast cancer. A higher incidence of breast cancer is reported in high-income countries than in SSA, although breast cancer in SSA presents at a younger age and at a more advanced stage. Some studies show that patients with breast cancer and HIV experience worse chemotherapy toxicity than do patients without HIV. Data on treatment outcomes are limited. The largest study showed worse treatment outcomes in patients with HIV, compared with their counterparts without HIV.ConclusionHIV infection has not been associated with different clinical presentation of breast cancer. However, some evidence suggests that concurrent diagnosis of HIV with breast cancer is associated with increased therapy-related toxicity and worse outcomes. Systematic prospective studies are needed to establish whether there is a specific association between breast cancer and HIV.

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Section: Introductionmentioning

confidence: 99%

Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Grover

Martei

Puri

et al. 2018

JGO

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“…Studies of cancer incidence among PLWHA have used International Classification of Diseases, Ninth Revision (ICD-9) codes[5]in claims databases to identify cancer diagnoses [6–8]. Claims data are primarily used for administrative purposes, such that their accuracy for epidemiologic investigations is variable.…”

Section: Introductionmentioning

confidence: 99%

Cancer Incidence in HIV-Infected Versus Uninfected Veterans: Comparison of Cancer Registry and ICD-9 Code Diagnoses

et al. 2014

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Background Given the growing interest in the cancer burden in persons living with HIV/AIDS, we examined the validity of data sources for cancer diagnoses (cancer registry versus International Classification of Diseases, Ninth Revision [ICD-9 codes]) and compared the association between HIV status and cancer risk using each data source in the Veterans Aging Cohort Study (VACS), a prospective cohort of HIV-infected and uninfected veterans from 1996 to 2008. Methods We reviewed charts to confirm potential incident cancers at four VACS sites. In the entire cohort, we calculated cancer-type-specific age-, sex-, race/ethnicity-, and calendar-period-standardized incidence rates and incidence rate ratios (IRR) (HIV-infected versus uninfected). We calculated standardized incidence ratios (SIR) to compare VACS and Surveillance, Epidemiology, and End Results rates. Results Compared to chart review, both Veterans Affairs Central Cancer Registry (VACCR) and ICD-9 diagnoses had approximately 90% sensitivity; however, VACCR had higher positive predictive value (96% versus 63%). There were 6,010 VACCR and 13,386 ICD-9 incident cancers among 116,072 veterans. Although ICD-9 rates tended to be double VACCR rates, most IRRs were in the same direction and of similar magnitude, regardless of data source. Using either source, all cancers combined, most viral-infection-related cancers, lung cancer, melanoma, and leukemia had significantly elevated IRRs. Using ICD-9, eight additional IRRs were significantly elevated, most likely due to false positive diagnoses. Most ICD-9 SIRs were significantly elevated and all were higher than the corresponding VACCR SIR. Conclusions ICD-9 may be used with caution for estimating IRRs, but should be avoided when estimating incidence or SIRs. Elevated cancer risk based on VACCR diagnoses among HIV-infected veterans was consistent with other studies.

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Epidemiological trends of cancers in AIDS patients

Agarwal

2014

HIV & AIDS Review

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Non-AIDS–Defining Cancers in New Orleans

Cited by 3 publications

References 36 publications

Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Cancer Incidence in HIV-Infected Versus Uninfected Veterans: Comparison of Cancer Registry and ICD-9 Code Diagnoses

Epidemiological trends of cancers in AIDS patients

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