Non-AIDS-Defining Malignancies

Incidence and risk factors for the occurrence of non‐AIDS‐defining cancers among human immunodeficiency virus‐infected individuals

“…NADCs that reportedly occur at an increased rate among HIV-infected patients compared with the general population include anorectal carcinoma(80-fold increase), Hodgkin disease (17-fold), melanoma (6fold), and lung carcinoma (3-fold). 21 Other studies also noted increased rates for brain tumors, leukemia, myeloma, as well as malignancies of the head and neck, lip, and testis. 4,5,22 Hepatocellular tumors have accounted for several NADCs and may become increasingly important among hepatitis B or C coinfected patients.…”

Human immunodeficiency virus and cancer. A population of HIV-infected patients at Hospital de Santa Maria and predictors of cancer

“…[13][14][15][16][17] NADCs that reportedly occur at a higher rate among HIVinfected patients compared to general population include anal cancer (80-fold increase), Hodgkin's lymphoma (17-fold), melanoma (six-fold), lung carcinoma (three-fold), hepatocellular carcinoma, vaginal, oropharyngeal and colorectal cancers, and leukemia. 3,18 In this study, skin and lung cancers were the most commonly found NADCs-IUR. On the other hand, hepatocellular carcinoma was the most frequent NADC-IR.…”

HIV and plasmablastic lymphoma manifesting in sinus, testicles, and bones: A further expansion of the disease spectrum

“…HIV is associated with many neoplasias, of which several are AIDS defining (non-Hodgkin's lymphoma, Kaposi syndrome, cervical carcinoma) [5,10]. Plasmacell malignancies are becoming more frequently noted in patients with HIV infection, although they are not yet AIDS-defining diseases [1,[4][5][6][7][8][9][13][14][15][16][17][18][19][20][21][22][23][24]. Patients with HIV infections have a 12-fold increased risk for myeloma compared to the general population [17], and this risk would be higher if other plasma-cell dyscrasias including plasmacytomas were included.…”

“…It is well known that patients infected with HIV are at increased risk for B-cell neoplasms, and these are considered AIDS-defining diseases [4][5][6]. It is now clear that HIV patients are also at increased risk of acquiring neoplasms with plasma-cell differentiation although these tumors are not considered AIDSdefining at this time [1,[7][8][9][10]. Both B-cell and plasma-cell tumors in this group of patients tend to be intermediate or high grade and are frequently associated with Epstein-Barr virus (EBV) infection [11], although the risk of acquiring a mature plasma-cell neoplasm is also increased.…”