Non-AIDS-Defining Malignancies in the HIV-Infected Population

Wang, Chia-ching J.; Silverberg, Michael J.; Abrams, Donald I.

doi:10.1007/s11908-014-0406-0

Cited by 60 publications

(60 citation statements)

References 71 publications

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“…The incidence of anal SCC was higher in the HAART era, 77.8 per 100,000 men vs. 21.8 per 100,000 men pre-HAART [4], given the improved survival results and therefore a longer possible exposure to HPV infection [5]. Anal SCC is one of the most common non-AIDS-defining cancers [6] and the most common HPV-driven cancer [7], in high-income settings, in HIV-positive patients. Less information related to anal SCC incidence has been published for other groups, but data showed an absolute IR of 12.3 per 100,000 person-years in solid-organ transplant recipients [8].…”

Section: Introductionmentioning

confidence: 99%

Recommendations Favoring Anal Cytology as a Method for Anal Cancer Screening: A Systematic Review

Albuquerque

Rios

Schmitt

2019

Cancers

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Clinicians are increasingly facing the decision of performing anal cancer screening in high-risk groups. Anal cytology is commonly the first approach. We systematically reviewed recommendations favoring anal cytology for anal cancer screening. Three databases were searched: PubMed, Scopus, and Embase, from January 2007 to 12 September 2019. The references cited by the retrieved articles and the websites of relevant organizations were also searched without language restrictions. Studies reporting guidelines from regional or national societies, institutes, or groups were included. Eight papers met the inclusion criteria and were selected, five were from the United States of America (USA) and three from Europe. There were no national recommendations published. There was one guideline specifically for solid-organ transplant recipients. The other seven targeted HIV-positive patients, with HIV-positive men who have sex with men (MSM) included as a screening group in all of these. Two recommendations favored screening in all HIV-positive patients. Five recommendations targeting HIV-positive patients made considerations about the cytology follow-up, recommending at least annual cytology in case of a normal result, and in case of squamous cytological abnormalities, a referral for anoscopy/high-resolution anoscopy. There were no recommendations for upper and lower age limits for screening. In conclusion, several societies recommend anal cancer screening using anal cytology in HIV-positive MSM patients. There is a lack of screening recommendations for other high-risk groups, with only one society recommending screening in transplant recipients.

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Section: Introductionmentioning

confidence: 99%

Recommendations Favoring Anal Cytology as a Method for Anal Cancer Screening: A Systematic Review

Albuquerque

Rios

Schmitt

2019

Cancers

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“…1 Immunosuppression in the context of both solid organ transplant as well as HIV has been associated with a higher rate of opportunistic infections and malignancies, 2-10 including non-melanoma skin cancers and lymphomas. Cancers have also been linked to viral infections in these vulnerable populations.…”

Section: Introductionmentioning

confidence: 99%

Are Patients with Inflammatory Bowel Disease on Chronic Immunosuppressive Therapy at Increased Risk of Cervical High-grade Dysplasia/Cancer? A Meta-analysis

Allegretti

Barnes

Cameron

2015

Inflammatory Bowel Diseases

120

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Background Immunosuppression is a mainstay of therapy for both induction and maintenance of remission for inflammatory bowel disease (IBD). Women who are chronically immunosuppressed have been shown to be at higher risk of developing cervical high-grade dysplasia and/or carcinoma. There is contradictory data whether immunosuppressed patients with IBD have the same risk profile for cervical cancer as patients with solid organ transplant or HIV infection. Objective To determine if the risk of cervical high-grade dysplasia and/or cancer is higher in patients with IBD on immunosuppressive therapy compared to the rates in the general population. Methods The studies were restricted to full text retrospective cohort studies and case controls that had a high (6-9) Newcastle- Ottawa Score. Results All pooled analyses were based on a random effects model. Five cohort studies and three case control studies of patients with IBD on any immunosuppression with cervical high-grade dysplasia/cancer (n=995) were included in the meta-analysis. The total IBD population in these studies was 77,116. IBD patients had an increased risk of cervical high-grade dysplasia/cancer compared to healthy controls (OR= 1.34, 95% CI: 1.23-1.46). Heterogeneity was detected (I2 = 34.23, Q= 10.64, df = 7; p = 0.15). The source was found to be the type of study, as well as the OR presented (crude vs. adjusted). Conclusions There is sufficient evidence to suggest an increased risk of cervical high-grade dysplasia/cancer in patients with IBD on immunosuppressive medications compared to the general population. Given this increased risk, increased screening intervals are indicated.

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“…Despite oral cancer being a non-AIDS defining malignancy, the AIDS patient however, has a higher likelihood becoming diagnosed with it. 16 The low percentage (78%) might therefore be attributable to some of the respondents taking into consideration the mentioned likelihood due in part to a weakened immune response. 17 Only 7% (26/362) respondents correctly identified all the treatment options (surgery, radiotherapy, chemotherapy, immunotherapy, targeted Therapy, combination Therapy) for oral cancer.…”

Section: Discussionmentioning

confidence: 99%

Oral cancer awareness among students from Mumbai University

Limaye

Bhatkhande

Sabu

et al. 2018

Int J Basic Clin Pharmacol

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Background: Oral cancer is among the top three types of cancers in India. Severe alcoholism, use of tobacco in the form of cigarettes, smokeless tobacco, and betel nut chewing are the most common risk factors for oral cancer. Often individuals with pre cancer even notice the alterations, such as reduced mouth opening in oral submucous fibrosis (OSMF), but they are not aware about the causes and consequences of these changes. Awareness about causes and features of oral cancers can be very helpful in prevention, control and early diagnosis of oral cancer.Methods: A cross-sectional study was carried out among students from Mumbai University, India during May-June 2017. Five hundred students were approached to participate in the study of which 400 agreed to participate. Pretested questionnaire was distributed and collected data was analyzed using IBM SPSS version 23.Results: There were 199 (49%) males and 201 (50%) females in the study and response rate was (80%). Respondents had good knowledge about oral cancer. Seventy four percent (268/362) respondents correctly identified smoking, and tobacco chewing as possible causes of oral cancer. Almost all (96%; 348/362) respondents correctly responded that oral cancer does not spread from person to person through touch or speaking. Seventy two percent (260/362) respondents believed that oral cancer is curable. Significantly higher number of male (98%) compared to female participants answered correctly to questions regarding spread of disease and occurrence of oral cancer in AIDS patients.Conclusions: Participants showed good knowledge about oral cancer. Female participants showed lesser knowledge compared to male counterparts. Details about oral cancer should be incorporated in the undergraduate curriculum and periodic awareness programs should be organized for students.

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Non-AIDS-Defining Malignancies in the HIV-Infected Population

Cited by 60 publications

References 71 publications

Recommendations Favoring Anal Cytology as a Method for Anal Cancer Screening: A Systematic Review

Recommendations Favoring Anal Cytology as a Method for Anal Cancer Screening: A Systematic Review

Are Patients with Inflammatory Bowel Disease on Chronic Immunosuppressive Therapy at Increased Risk of Cervical High-grade Dysplasia/Cancer? A Meta-analysis

Oral cancer awareness among students from Mumbai University

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