Non-alcoholic fatty liver disease – a procoagulant condition?

Virović-Jukić, Lucija; Stojsavljević-Shapeski, Sanja; Forgač, Jelena; Kukla, Michał; Mikolašević, Ivana

doi:10.3325/cmj.2021.62.25

Cited by 17 publications

(23 citation statements)

References 59 publications

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“…При НАЖБП эндотелиальная дисфункция ведет к развитию протромботического состояния, микроваскулярных изменений в виде появления тромбов в микроциркуляторном русле печени. Гиперкоагуляционный статус ответственен за апоптоз гепатоцитов, активацию звездчатых клеток, что способствует ремоделированию и фиброзу даже в отсутствие явного внутрипеченочного тромбоза [25].…”

Section: Discussionunclassified

The possibilities of soluble selectins in the prediction of severe ﬁ brosis in nonalcoholic fatty liver disease

Koroy

Kravchenko

Yagoda

2022

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The aim of the work was to study the relationship of selectins with hepatic ﬁ brosis in nonalcoholic fatty liver disease (NAFLD).Material and methods. In 40 patients with histologically conﬁ rmed NAFLD (42.5% of women, 57.5% of men) aged 19 to 65 years (mean age — 40.93±1.95 years), the levels of E-, P- and L-selectins in the blood was studied. Severe liver steatosis was present in 47.5% of patients, nonalcoholic steatohepatitis was observed in 57.5% of cases, and severe liver ﬁ brosis was detected in 22.5% of patients. The control group consisted of 60 practically healthy people.Results. The increase of plasma levels of all selectins was observed in NAFLD. The blood levels of E-selectin elevated with increasing of histological signs of hepatic steatosis. The concentration of E- and P-selectins in the blood was higher in patients with nonalcoholic steatohepatitis than in cases of its absence. The maximum values of E- and P-selectins in the blood were present in severe liver ﬁ brosis. Correlation of soluble E- and P-selectins with ﬁ brosis index was determined. The risk of severe ﬁ brosis in NAFLD increased 27-fold with E-selectin values above 89 ng/ml and 33-fold in cases of P-selectin values greater than 166 ng/ml. The accuracy of the above levels of E- and P-selectins in predicting severe ﬁ brosis in NAFLD was 80.0 and 82.5%, respectively. The probability of severe liver ﬁ brosis in NAFLD was related with the presence of insulin resistance and increased levels of P-selectin in the blood.Conclusion. Determination of the proﬁ le of soluble selectins in NAFLD allows us to state the severity of liver ﬁ brosis and stratify patients into groups with its diﬀ erent severity.

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Section: Discussionunclassified

The possibilities of soluble selectins in the prediction of severe ﬁ brosis in nonalcoholic fatty liver disease

Koroy

Kravchenko

Yagoda

2022

jour

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“…The alternation of the synthesis of coagulation factors in the liver causes coagulation disorders in patients with chronic liver diseases [ 32 ]. Although both prolonged bleeding and hypercoagulation can appear according to the balance of procoagulant and anticoagulant factors, those changes tend to proceed simultaneously, and their balance is restored and rebalanced in most patients with cirrhosis [ 32 , 33 ]. However, in patients with NAFLD, the frequency of both arterial and venous thrombotic events is increased compared with the absence of NAFLD, owing to hypercoagulation [ 15 , 34 ].…”

Section: The Interlink Connections Of Ascvd and Nafldmentioning

confidence: 99%

Association between Cardiovascular Disease and Liver Disease, from a Clinically Pragmatic Perspective as a Cardiologist

et al. 2023

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Cardiovascular diseases and liver diseases are closely related. Non-alcoholic fatty liver disease has the same risk factors as those for atherosclerotic cardiovascular disease and may also be a risk factor for atherosclerotic cardiovascular disease on its own. Heart failure causes liver fibrosis, and liver fibrosis results in worsened cardiac preload and congestion. Although some previous reports regard the association between cardiovascular diseases and liver disease, the management strategy for liver disease in patients with cardiovascular diseases is not still established. This review summarized the association between cardiovascular diseases and liver disease. In patients with non-alcoholic fatty liver disease, the degree of liver fibrosis progresses with worsening cardiovascular prognosis. In patients with heart failure, liver fibrosis could be a prognostic marker. Liver stiffness assessed with shear wave elastography, the fibrosis-4 index, and non-alcoholic fatty liver disease fibrosis score is associated with both liver fibrosis in patients with liver diseases and worse prognosis in patients with heart failure. With the current population ageing, the importance of management for cardiovascular diseases and liver disease has been increasing. However, whether management and interventions for liver disease improve the prognosis of cardiovascular diseases has not been fully understood. Future investigations are needed.

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“…The homeostasis of the intestinal flora plays a crucial role in the maintenance of human health ( 61 ), and disturbance in the intestinal flora is closely associated with many diseases ( 62 ). At present, more and more studies have been performed on the effects of TCM on the liver–gut axis, but current research is still limited.…”

Section: Future Perspectivesmentioning

confidence: 99%

“Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease

Ke¹,

Xu²,

Zeng³

2022

Front. Endocrinol.

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Non-alcoholic fatty liver disease (NAFLD) occurs when fat accumulates in the liver even without excessive alcohol intake. Among the current therapeutic approaches for NAFLD, lifestyle modification with dietary changes and regular exercise is the mainstay treatment. With the rise of intestinal microecology, regulation of the “liver–gut” axis can be an effective treatment for NAFLD. This review aimed to assess the modulation of the liver–gut microbiota axis with traditional Chinese medicine (TCM) as a therapeutic approach to NAFLD and further explored its application in the newly discovered therapeutic avenues beyond NAFLD treatment.

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Non-alcoholic fatty liver disease – a procoagulant condition?

Cited by 17 publications

References 59 publications

The possibilities of soluble selectins in the prediction of severe ﬁ brosis in nonalcoholic fatty liver disease

The possibilities of soluble selectins in the prediction of severe ﬁ brosis in nonalcoholic fatty liver disease

Association between Cardiovascular Disease and Liver Disease, from a Clinically Pragmatic Perspective as a Cardiologist

“Liver–gut” axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease

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