Non-alcoholic Fatty Liver Disease and Longitudinal Cognitive Changes in Middle-Aged and Elderly Adults

Qi, Lei; Liu, Chang; Hu, Feifei; Zhang, Yumei

doi:10.3389/fmed.2021.738835

Cited by 20 publications

(23 citation statements)

References 40 publications

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“…Of these 9 articles, 8 failed to provide relevant data and outcomes and 1 article provided incomplete data. Ultimately, 7 studies (Labenz et al, 2021 ; Lampignano et al, 2021 ; Shang et al, 2021 ; Jeong et al, 2022 ; Kim et al, 2022 ; Liu et al, 2022 ; Yu et al, 2022 ) were included in this study. The search selection process is presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies were included in this review. Five studies (Labenz et al, 2021 ; Shang et al, 2021 ; Jeong et al, 2022 ; Kim et al, 2022 ; Liu et al, 2022 ) were cohort studies and 2 studies (Lampignano et al, 2021 ; Yu et al, 2022 ) were case–control studies. The 7 studies were published from 2020 to 2022 and involved a total of 891,562 individuals, with sample sizes ranging from 1542 to 608,994 individuals per study.…”

Section: Resultsmentioning

confidence: 99%

“…There were 2 studies (Jeong et al, 2022 ; Kim et al, 2022 ) from Korea, 1 (Yu et al, 2022 ) from the United States, 1 (Liu et al, 2022 ) from China, 1 (Shang et al, 2021 ) from Switzerland, 1 (Labenz et al, 2021 ) from Germany, and 1 from (Lampignano et al, 2021 ) Italy. The results of 5 studies (Labenz et al, 2021 ; Lampignano et al, 2021 ; Shang et al, 2021 ; Jeong et al, 2022 ; Kim et al, 2022 ) described outcome measures of dementia, and the 2 other studies (Liu et al, 2022 ; Yu et al, 2022 ) involved cognitive impairment. The main characteristics of the included studies are shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Two studies (Liu et al, 2022 ; Yu et al, 2022 ) assessed the association between NAFLD and risk of cognitive impairment. As shown in Figure 2 , data analysis showed a strong link between NAFLD and cognitive impairment (OR = 1.44; 95% CI: 1.17–1.78; I 2 = 0%; P = 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Figures 4, 5 studies (Labenz et al, 2021;Lampignano et al, 2021;Shang et al, 2021;Jeong et al, 2022;Kim et al, 2022;Liu et al, 2022;Yu et al, 2022) described the association of all-cause dementia with NAFLD; however, results from the data showed that the relationship between NAFLD and an increased risk of all-cause dementia was not obvious (OR = 1.03; 95% CI: 0.97-1.09; I 2 = 84.7%; P = 0.341). Since Alzheimer Disease (AD) and vascular dementia (VD) belong to the category of dementia, we extracted the data of AD and VD separately for reanalysis.…”

Section: Nafld and Risk Of Alzheimer Disease And Vascular Dementiamentioning

confidence: 98%

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Risk of dementia or cognitive impairment in non-alcoholic fatty liver disease: A systematic review and meta-analysis

Wang

Sang

Zheng

2022

Front. Aging Neurosci.

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ObjectivesTo investigate whether non-alcoholic fatty liver disease (NAFLD) increases the risk of dementia or cognitive impairment.MethodsA systematic search of the literature in the PubMed, Excerpta Medica Database (EMBASE), Cochrane Library, and Web of Science databases was conducted, covering the period from the inception of each database to 22 May 2022. Statistical analysis of non-alcoholic fatty liver disease and the risk of cognitive impairment or dementia based on data extracted from each article was performed using Stata software v. 16.0. The quality of this study was assessed using the Newcastle-Ottawa Scale (NOS) for assessing the quality of cohort and case-control studies and the American Agency for Healthcare Research and Quality (AHRQ) methodology checklist for assessing the quality of cross-sectional studies. Funnel plots and the Egger's test were used to assess publication bias.ResultsWe included 7 studies comprising 891,562 individuals from 6 countries, which were published between 2020 and 2022. The pooling analysis showed that a history of NAFLD was associated with cognitive impairment [odds ratio (OR) = 1.44; 95% CI: 1.17–1.78; heterogeneity (I2) = 0%; P = 0.001]. A history of NAFLD was not associated with an increased risk of all-cause dementia (OR = 1.03; 95% CI: 0.97–1.09; I2 = 84.7%; P = 0.341) or Alzheimer disease (OR = 0.95; 95% CI: 0.83–1.09; I2 = 61.0%; P = 0.489). In contrast, NAFLD was associated with an obvious reduction of the risk of vascular dementia (OR = 0.88; 95% CI: 0.79–0.98; I2 = 0.0%; P = 0.020). In the subgroup analysis, male and female patients with NAFLD showed an equal risk of dementia or cognitive impairment. The risk of dementia or cognitive impairment in the cross-sectional study (OR = 1.49; 95% CI: 1.19–1.88; I2 = 0.0%; P = 0.001) was slightly higher than that in the retrospective cohort (OR = 1.03; 95% CI: 0.97–1.09; I2 = 84.3%; P = 0.294).ConclusionsNAFLD was associated with an increased risk of cognitive impairment and a decreased risk of vascular dementia. More studies are needed to clarify the pathophysiological mechanism underlying the association between NAFLD and dementia or cognitive impairment.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#recordDetails, identifier: CRD42022334492.

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