Non-alcoholic fatty liver disease and periodontal disease: A systematic review and meta-analysis of cross-sectional studies

Aguiar, Inácio Lima Silva; Santos-Lins, Larissa Souza; Brasil-Oliveira, Rebeca; Cotrim, Helma Pinchemel; Lins-Kusterer, Liliane

doi:10.1016/j.ajg.2023.09.005

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…33 Epidemiological evidence showed that liver fibrosis is related to the more serious symptoms of periodontitis. 31,34 The possible explanation might come from the interactions between microorganisms through the oral-gut-liver axis. 33,35 HCV can result in progress liver complications including liver fibrosis, cirrhosis, and hepatocellular carcinoma, 36 suggesting its possibility of being the risk factor of periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, nonalcoholic fatty liver disease is considered to share the common risk factor with periodontitis, 32 and has been proven to related to periodontitis 33 . Epidemiological evidence showed that liver fibrosis is related to the more serious symptoms of periodontitis 31,34 . The possible explanation might come from the interactions between microorganisms through the oral‐gut‐liver axis 33,35 .…”

Section: Discussionmentioning

confidence: 99%

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Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014

Fang,

Liu,

Mao

et al. 2024

Journal of Medical Virology

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Periodontitis is a cumulative inflammatory disease associated with multiple health conditions and various systemic diseases. As a common disease, virus infection along with its consequences has become a serious health burden. The study aims to evaluate the relationship between common viruses including hepatitis virus, human immunodeficiency virus (HIV), herpes simplex virus (HSV), human papillomavirus (HPV), and periodontitis. The data from the US National Health and Nutrition Examination Survey (NHANES) 2009−2014 was adopted and screened through, including 10 714 participants. Generalized linear regression was conducted to verify the relationships between the virus infections and periodontitis. Moreover, we also performed analyses in age and gender subgroups. The results suggested that the infection of HCV, HSV‐1, and HSV‐2 was significantly associated with the prevalence of periodontitis (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.26−1.70; OR 1.09, 95% CI 1.05−1.13; OR 1.06, 95% CI 1.01 ‐ 1.11, respectively) and risk of developing moderate or severe periodontitis (OR 1.51, 95% CI 1.29−1.77; OR 1.08, 95% CI 1.04−1.12; OR 1.05, 95% CI 1.01−1.10, respectively) after adjusting all relevant co‐factors. Subgroup analyses revealed a steady association between periodontitis and hepatitis C virus (HCV) or HSV‐1 infection, while the relationship between HSV‐2 and HPV infection can also be found in some subgroups. The presence of HCV and HSV infection was found to be significantly associated with the prevalence of periodontitis, including moderate or severe cases. Moreover, the association of periodontitis and HPV infection can also be observed in people < 35 years.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014

Fang,

Liu,

Mao

et al. 2024

Journal of Medical Virology

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“…One meta-analysis was conducted regarding study evaluations of periodontal disease in NAFLD. "The odds ratio (1.91; 95% CI 1.21-3.02; p = 0.006) indicates that the chance of presenting periodontal disease is 91%" greater among patients with NAFLD than patients without NAFLD [ 59 ]. Chen et al reported that affirmative relations link periodontal disorder and hepatic cirrhosis (OR = 2.28; 95% CI = 1.50-3.48) and NAFLD (OR = 1.19; 95% CI = 1.06-1.33) [ 60 ].…”

Section: Introductionmentioning

confidence: 99%

“…Chen et al reported that affirmative relations link periodontal disorder and hepatic cirrhosis (OR = 2.28; 95% CI = 1.50-3.48) and NAFLD (OR = 1.19; 95% CI = 1.06-1.33) [ 60 ]. Aguiar et al revealed that patients with periodontal disorders instigate the progression of NAFLD because of distorted sphingolipid metabolism that headed to intensified insulin resistance, hepatic inflammation [ 59 ], and mitochondrial dysfunction [ 61 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Nonalcoholic Fatty Liver Disease in Periodontitis: A Bidirectional Relationship

Vegda,

Patel,

Girdhar

et al. 2024

Cureus

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Nonalcoholic fatty liver disease (NAFLD) and periodontitis share common risk factors such as obesity, insulin resistance (IR), and dyslipidemia, which contribute to systemic inflammation. It has been suggested that a bidirectional relationship exists between NAFLD and periodontitis, indicating that one condition may exacerbate the other. NAFLD is characterized by excessive fat deposition in the liver and is associated with low-grade chronic inflammation. There are several risk factors for the development of NAFLD, including gender, geriatric community, race, ethnicity, poor sleep quality and sleep deprivation, physical activity, nutritional status, dysbiosis gut microbiota, increased oxidative stress, overweight, obesity, higher body mass index (BMI), IR, type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS), dyslipidemia (hypercholesterolemia), and sarcopenia (decreased skeletal muscle mass). This systemic inflammation can contribute to the progression of periodontitis by impairing immune responses and exacerbating the inflammatory processes in the periodontal tissues. Furthermore, individuals with NAFLD often exhibit altered lipid metabolism, which may affect oral microbiota composition, leading to dysbiosis and increased susceptibility to periodontal disease. Conversely, periodontitis has been linked to the progression of NAFLD through mechanisms involving systemic inflammation and oxidative stress. Chronic periodontal inflammation can release pro-inflammatory cytokines and bacterial toxins into the bloodstream, contributing to liver inflammation and exacerbating hepatic steatosis. Moreover, periodontitis-induced oxidative stress may promote hepatic lipid accumulation and IR, further aggravating NAFLD. The interplay between NAFLD and periodontitis underscores the importance of comprehensive management strategies targeting both conditions. Lifestyle modifications such as regular exercise, a healthy diet, and proper oral hygiene practices are crucial for preventing and managing these interconnected diseases. Additionally, interdisciplinary collaboration between hepatologists and periodontists is essential for optimizing patient care and improving outcomes in individuals with NAFLD and periodontitis.

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The impact of systemic administration of polyphenols on periodontitis associated with diabetes mellitus: a systematic review

Rogalnikovaite,

Antipoviene,

Burbulyte

et al. 2024

AOS

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Objective: The aim of this work was to explore the potential of polyphenol supplement consumption in enhancing the treatment of periodontitis and diabetes mellitus in both diabetic animals and humans. Materials and methods: A comprehensive search across eight databases (MEDLINE, EBSCO, Taylor & Francis, PRIMO, Web of Science, Wiley Online Library, ScienceDirect, and SAGE Journals) and two registers (ClinicalTrials.gov and Cochrane Library Trials) was conducted. Methodological quality assessment employed the Cochrane Collaboration Risk of Bias Assessment Tool for randomised controlled trials and the Systematic Review Centre for Laboratory Animal Experimentation Risk of Bias Tool for experimental animal studies. Results: Ten articles meeting inclusion criteria were identified. Three clinical studies demonstrated significant reductions in probing depth (PD) and clinical attachment loss (CAL). Ginger supplementation showed a decrease in CAL (–0.57 ± 0.50 vs. –0.14 ± 0.35, p = 0.003) and PD (–0.52 ± 0.51 vs. –0.19 ± 0.51, p = 0.04), while resveratrol supplementation exhibited a reduction in PD (–1.1 ± 0.58 vs. –0.6 ± 0.47, p < 0.001). Additionally, cranberry juice supplementation led to a decrease in PD (–0.56 ± 0.03, p < 0.001). However, there was no significant improvement in inflammation status. Although polyphenol supplementation did not impact fasting blood glucose levels, it did result in improved insulin resistance (3.66 ± 0.97 vs. 4.49 ± 1.56, p = 0.045). In diabetic animals, six studies reported a significant reduction (p < 0.05) in bone loss along with marked improvements in inflammation status. Conclusions: Despite the promising results observed in the included studies, the overall evidence supporting the positive effects of polyphenols on periodontal and diabetes mellitus status, along with their anti-inflammatory properties, remains inadequate.

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Non-alcoholic fatty liver disease and periodontal disease: A systematic review and meta-analysis of cross-sectional studies

Cited by 5 publications

References 29 publications

Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014

Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009−2014

Role of Nonalcoholic Fatty Liver Disease in Periodontitis: A Bidirectional Relationship

The impact of systemic administration of polyphenols on periodontitis associated with diabetes mellitus: a systematic review

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