Non-alcoholic fatty liver disease and women's health

Livzan, M. А.; Syrovenko, M.I.; Кролевец, Т. С.

doi:10.32364/2587-6821-2023-7-5-9

Cited by 4 publications

(1 citation statement)

References 69 publications

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“…Non alcoholic fatty liver disease, gender differences, dyslipidemia, cytokines, endothelial dysfunction. [3]. В недавно опублико ванных исследованиях отмечены тенденция к увеличению распространенности НАЖБП среди женщин за последние 10 лет [4], а так же более резкий рост смертности по сравне нию с мужчинами [5], обусловленный сердеч но сосудистыми осложнениями, что относит их к группе риска.…”

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Gender characteristics of non-alcoholic fatty liver disease course

Bulatova,

Shevlyukova,

Tsymbal

2023

Perm Medical Journal

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Objective. To study the clinical picture, functional indicators of the liver, lipid spectrum, proinflammatory cytokine levels and epithelial dysfunction markers in patients with non-alcoholic fatty liver disease (NAFLD) so as to detect gender differences. Materials and methods. Fifty-two persons with a mean age of 43.0 ± 11.1 years including 17 men (33 %) and 35 women (67 %), who suffered from NAFLD against the background of obesity were examined. The comparison group enclosed 30 practically healthy persons aged 42.3 ± 7.0 years, who had no liver pathology and obesity. The laboratory study included the assessment of functional liver tests, lipid spectrum, proinflammatory cytokine levels and epithelial dysfunction markers.Steatosis of the liver was determined with the method of ultrasonic investigation. Results. In the examined group with NAFLD, there prevailed women (67 %). The structure of complains and concomitant pathology had no marked gender differences. The USI showed the symptoms of liver steatosis in all the patients. Among men and women with NAFLD, normal transaminase levels, cholestasis syndrome, more expressed in men, similar disorders of blood lipid spectrum were registered. The proinflammatory cytokine concentrations in the blood serum of female patients with steatosis were significantly higher than in the comparison group and among males with NAFLD. The disturbance of the endothelial angiogenic function in the form of increased vasculoendothelial growth factor concentration more pronounced in men than in steatosis women was detected (р = 0.031). Conclusions. Among women with NAFLD, slightly expressed cholestasis syndrome, dyslipidemia, signs of systemic inflammation with increased proinflammatory cytokine concentration and disturbance of angiogenic function of endothelium were registered. In men with liver steatosis, there was identified cholestasis syndrome, dyslipidemia, and angiogenic dysfunction of endothelium, more marked than in women.

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Gender characteristics of non-alcoholic fatty liver disease course

Bulatova,

Shevlyukova,

Tsymbal

2023

Perm Medical Journal

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Non-alcoholic fatty liver disease and pregnancy

Shevlyukovа,

Bulatovа

2024

Perm Medical Journal

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The issues of epidemiology, risk factors, and pathogenetic mechanisms of non-alcoholic fatty liver disease during pregnancy are considered in the review. The impact of liver steatosis and obesity on the course and outcome of pregnancy, the perinatal state of the mother and fetus are described. Fluctuations in the hormonal spectrum, an increase in body weight, which can affect the development and progression of liver steatosis, occur during pregnancy. Women of reproductive age with metabolic syndrome, obesity require a thorough examination and, if it is necessary, optimization of metabolic health before planning pregnancy. Pregnant women with liver pathology need dynamic control and prevention of disease progression and associated obstetric complications.

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Features of the course of non-alcoholic fatty liver disease in women at different age periods: literature review

Bulatova,

Shevlyukova

2024

Medicinskij sovet

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The review examines the epidemiology and risk factors of non-alcoholic fatty liver disease (NAFLD) for women. According to various sources, the global prevalence of NAFLD ranges from 20 to 40% of the adult population in the world. In Russia, 37.3% of polyclinic patients have NAFLD. NAFLD can occur at any age and has differences in prevalence and severity depending on ethnicity and gender. Over the past 10 years, there has been a trend towards an increase in the prevalence of NAFLD among women, as well as a sharper increase in mortality compared to men. Regardless of gender, prognostically significant risk factors for NAFLD include age, obesity, type 2 diabetes mellitus, insulin resistance, dyslipidemia. The clinical course and prognosis of NAFLD in women depends on age, reproductive stage and use of synthetic hormones. Premenopausal women have less pronounced liver fibrosis and a better life prognosis compared to postmenopausal men and women. The article describes the features of the course of NAFLD in the reproductive period, pre- and postmenopausal period, characterizes the effect of liver steatosis on the course and outcome of pregnancy, the perinatal condition of the mother and fetus. Thus, there are gender differences in the prevalence, risk factors, fibrosis, and clinical outcomes of NAFLD. The prevalence and severity of NAFLD in reproductive age is higher in men, but after menopause, there is an increase in this pathology in women, especially those with metabolic disorders. Liver steatosis can affect the course of pregnancy, labor and postpartum periods.

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Non-alcoholic fatty liver disease and women's health

Cited by 4 publications

References 69 publications

Gender characteristics of non-alcoholic fatty liver disease course

Gender characteristics of non-alcoholic fatty liver disease course

Non-alcoholic fatty liver disease and pregnancy

Features of the course of non-alcoholic fatty liver disease in women at different age periods: literature review

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