Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes

Sarkar, Monika; Grab, Joshua D.; Dodge, Jennifer L.; Gunderson, Erica P.; Rubin, Jessica B.; Irani, Roxanna A.; Cedars, Marcelle I.; Terrault, Norah A.

doi:10.1016/j.jhep.2020.03.049

Cited by 104 publications

(101 citation statements)

References 32 publications

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“…In their otherwise excellent study, Sarkar et al 1 do not analyze the possibility of long-term hepatic effects in children born to mothers with non-alcoholic fatty liver disease (NAFLD).…”

Section: To the Editormentioning

confidence: 99%

From pregnant women to infants: Non-alcoholic fatty liver disease is a poor inheritance

Mosca

Panera

Maggiore

et al. 2020

Journal of Hepatology

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“…In their otherwise excellent study, Sarkar et al 1 do not analyze the possibility of long-term hepatic effects in children born to mothers with non-alcoholic fatty liver disease (NAFLD).…”

Section: To the Editormentioning

confidence: 99%

From pregnant women to infants: Non-alcoholic fatty liver disease is a poor inheritance

Mosca

Panera

Maggiore

et al. 2020

Journal of Hepatology

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“…A large US study using discharge diagnoses reported higher rates of hypertensive complications (OR, 3.1; 95% CI, 2.6-3.8), preterm births (OR, 1.6; 95% CI, 1.3-2.0), and postpartum hemorrhage (OR, 1.7; 95% CI, 1.3-2.2) in mothers with NAFLD compared to those without liver disease. (209) Fatty liver based on US findings has been associated with higher likelihood of gestational diabetes mellitus (GDM), independent of BMI and age. (210)(211)(212) A population-based cohort study also reported higher rates of cesarean delivery (64.2% versus 16.8%), preterm births (16.4% versus 5.1%), and small for gestational age births (5.8% versus 2.8%) (213) in NAFLD compared to non-NAFLD controls, even after adjustment for BMI and pre-GDM.…”

Section: Nonalcoholic Fatty Liver Diseasementioning

confidence: 99%

Reproductive Health and Liver Disease: Practice Guidance by the American Association for the Study of Liver Diseases

et al. 2021

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“…In a recent study using nationally representative discharge data, the prevalence of NAFLD in pregnancy was shown to nearly triple over the preceding decade. 23 Moreover, having NAFLD in pregnancy was associated with serious maternal and fetal complications, including preterm birth, hypertensive complications (preeclampsia, eclampsia, or hemolysis, elevated liver tests, and low platelet [HELLP] syndrome), and postpartum hemorrhage. These findings were independent of preexisting metabolic comorbidities, as well as GDM.…”

Section: Nafld and Pregnancymentioning

confidence: 99%

Reproductive Health and Nonalcoholic Fatty Liver Disease in Women: Considerations Across the Reproductive Lifespan

Sarkar

Suzuki

2020

Clinical Liver Disease

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States. 1 Emerging US data highlight the largest increase in NAFLD incidence among adults younger than 40 years. 2 Nonalcoholic steatohepatitis (NASH) is the most rapidly growing indication for liver transplantation (LT) in young adults, and now is the most common indication for LT in women. 3,4 Thus, the public health implications of NAFLD/ NASH in women of reproductive age are vast. The clinical management of young women must therefore consider female-specific risk factors for NAFLD, as well as the implications of NAFLD on reproductive health. rePrODUCTive risK FaCTOrs anD naFlD in wOMen Polycystic Ovary SyndromePolycystic ovary syndrome (PCOS) is now recognized by the American Association for the Study of Liver Diseases as a risk factor for NAFLD, 5 with 40% to 55% of women with PCOS having imaging-confirmed NAFLD. 6,7 PCOS is a common disease, affecting ~10% of women of reproductive age. Typical features of PCOS include insulin resistance, irregular menstrual cycles, polycystic ovaries, and laboratory or clinical signs of elevated androgen levels (i.e., testosterone). Approximately 80% of insulin-resistant women with PCOS are either overweight or obese, 8 and PCOS is further associated with more rapid progression from insulin resistance to frank diabetes. 9 Elevated liver enzymes are reported in approximately one-third of women with PCOS, which are higher than the values in age-and body mass index (BMI)-matched controls. 10 Cytokeratin 18 levels, a biomarker of NASH, are also higher in women with PCOS, independent of age and BMI. 11 Less data are available on NASH histology and PCOS. A recent study of biopsy-confirmed NAFLD in women of reproductive age found a similar

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Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes

Cited by 104 publications

References 32 publications

From pregnant women to infants: Non-alcoholic fatty liver disease is a poor inheritance

From pregnant women to infants: Non-alcoholic fatty liver disease is a poor inheritance

Reproductive Health and Liver Disease: Practice Guidance by the American Association for the Study of Liver Diseases

Reproductive Health and Nonalcoholic Fatty Liver Disease in Women: Considerations Across the Reproductive Lifespan

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