Non-alcoholic fatty liver disease severity and metabolic complications in obese children: impact of omega-3 fatty acids

Spahis, Schohraya; Alvarez, Fernando; Ahmed, N; Dubois, Josée; Jalbout, Ramy El; Paganelli, Massimiliano; Grzywacz, Kelly; Delvin, Edgard; Peretti, Noël; Lévy, Émile

doi:10.1016/j.jnutbio.2018.03.025

Cited by 40 publications

(24 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nobili et al [ 80 ] found that oxidative stress is highly prevalent in pediatric NAFLD. Reductions in oxidative stress parameters have been observed in clinical trials in children with NAFLD after treatment with vitamin E plus hydroxytyrosol [ 81 ], calorie restriction with lycopene-rich tomato juice supplementation [ 82 ], and n-3 PUFA supplementation [ 83 ]. Furthermore, lipid oxidation products (LPOs) such as 4-hydroxynonenal and malondialdehyde are produced as a result of the interaction between reactive oxygen species (ROS) and PUFAs derived from membrane phospholipids [ 84 ].…”

Section: Mitochondrial Dysfunction and Oxidative Stress In The Promentioning

confidence: 99%

Pediatric Non-Alcoholic Fatty Liver Disease: Nutritional Origins and Potential Molecular Mechanisms

et al. 2020

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is the number one chronic liver disease worldwide and is estimated to affect nearly 40% of obese youth and up to 10% of the general pediatric population without any obvious signs or symptoms. Although the early stages of NAFLD are reversible with diet and lifestyle modifications, detecting such stages is hindered by a lack of non-invasive methods of risk assessment and diagnosis. This absence of non-invasive means of diagnosis is directly related to the scarcity of long-term prospective studies of pediatric NAFLD in children and adolescents. In the majority of pediatric NAFLD cases, the mechanisms driving the origin and rapid progression of NAFLD remain unknown. The progression from NAFLD to non-alcoholic steatohepatitis (NASH) in youth is associated with unique histological features and possible immune processes and metabolic pathways that may reflect different mechanisms compared with adults. Recent data suggest that circulating microRNAs (miRNAs) are important new biomarkers underlying pathways of liver injury. Several factors may contribute to pediatric NAFLD development, including high-sugar diets, in utero exposures via epigenetic alterations, changes in the neonatal microbiome, and altered immune system development and mitochondrial function. This review focuses on the unique aspects of pediatric NAFLD and how nutritional exposures impact the immune system, mitochondria, and liver/gastrointestinal metabolic health. These factors highlight the need for answers to how NAFLD develops in children and for early stage-specific interventions.

show abstract

Section: Mitochondrial Dysfunction and Oxidative Stress In The Promentioning

confidence: 99%

Pediatric Non-Alcoholic Fatty Liver Disease: Nutritional Origins and Potential Molecular Mechanisms

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In developing countries, the incidence of the disease is about 15%, but in obese patients, the incidence is as high as 50% or more [4]. It has been shown that MAFLD is not associated with liver-related disease, but increasing research has demonstrated that MAFLD is linked with various chronic diseases [6]. For example, MAFLD can increase the risk of hypertension, type 2 diabetes mellitus, oxidative stress, chronic kidney disease, etc., which all threaten human health [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Consumption of Wild Rice (Zizania latifolia) Prevents Metabolic Associated Fatty Liver Disease through the Modulation of the Gut Microbiota in Mice Model

Hou

Ning

et al. 2020

IJMS

View full text Add to dashboard Cite

Metabolic associated fatty liver disease (MAFLD) due to excess weight and obesity threatens public health worldwide. Gut microbiota dysbiosis contributes to obesity and related diseases. The cholesterol-lowering, anti-inflammatory, and antioxidant effects of wild rice have been reported in several studies; however, whether it has beneficial effects on the gut microbiota is unknown. Here, we show that wild rice reduces body weight, liver steatosis, and low-grade inflammation, and improves insulin resistance in high-fat diet (HFD)-fed mice. High-throughput 16S rRNA pyrosequencing demonstrated that wild rice treatment significantly changed the gut microbiota composition in mice fed an HFD. The richness and diversity of the gut microbiota were notably decreased upon wild rice consumption. Compared with a normal chow diet (NCD), HFD feeding altered 117 operational taxonomic units (OTUs), and wild rice supplementation reversed 90 OTUs to the configuration in the NCD group. Overall, our results suggest that wild rice may be used as a probiotic agent to reverse HFD-induced MAFLD through the modulation of the gut microbiota.

show abstract

“…In the last two decades, strategies to limit the deleterious effects of the MetS have been focused on diet regimen containing natural fruits, green vegetables, whole grains, legumes, probiotics, vitamin C, vitamin E, and ω-3 polyunsaturated-fatty acids [ 20 , 144 , 145 , 146 , 147 , 148 ]. Likewise, prebiotics, including polyphenols with their prebiotic potential, have also demonstrated promising effects on IR, glycemia, lipid profile, and CVD [ 8 , 134 , 149 ].…”

Section: Polyphenols and Metabolic Syndromementioning

confidence: 99%

Insight into Polyphenol and Gut Microbiota Crosstalk: Are Their Metabolites the Key to Understand Protective Effects against Metabolic Disorders?

et al. 2020

Self Cite

View full text Add to dashboard Cite

Lifestyle factors, especially diet and nutrition, are currently regarded as essential avenues to decrease modern-day cardiometabolic disorders (CMD), including obesity, metabolic syndrome, type 2 diabetes, and atherosclerosis. Many groups around the world attribute these trends, at least partially, to bioactive plant polyphenols given their anti-oxidant and anti-inflammatory actions. In fact, polyphenols can prevent or reverse the progression of disease processes through many distinct mechanisms. In particular, the crosstalk between polyphenols and gut microbiota, recently unveiled thanks to DNA-based tools and next generation sequencing, unravelled the central regulatory role of dietary polyphenols and their intestinal micro-ecology metabolites on the host energy metabolism and related illnesses. The objectives of this review are to: (1) provide an understanding of classification, structure, and bioavailability of dietary polyphenols; (2) underline their metabolism by gut microbiota; (3) highlight their prebiotic effects on microflora; (4) discuss the multifaceted roles of their metabolites in CMD while shedding light on the mechanisms of action; and (5) underscore their ability to initiate host epigenetic regulation. In sum, the review clearly documents whether dietary polyphenols and micro-ecology favorably interact to promote multiple physiological functions on human organism.

show abstract

Non-alcoholic fatty liver disease severity and metabolic complications in obese children: impact of omega-3 fatty acids

Cited by 40 publications

References 85 publications

Pediatric Non-Alcoholic Fatty Liver Disease: Nutritional Origins and Potential Molecular Mechanisms

Pediatric Non-Alcoholic Fatty Liver Disease: Nutritional Origins and Potential Molecular Mechanisms

Consumption of Wild Rice (Zizania latifolia) Prevents Metabolic Associated Fatty Liver Disease through the Modulation of the Gut Microbiota in Mice Model

Insight into Polyphenol and Gut Microbiota Crosstalk: Are Their Metabolites the Key to Understand Protective Effects against Metabolic Disorders?

Contact Info

Product

Resources

About