Non-Alcoholic Partially Reversible Marchiafava-Bignami Disease: Review and Relation with Reversible Splenial Lesions

Caulo, Massimo; Briganti, C.; Notturno, Francesca; Committeri, Giorgia; Mattei, Peter A.; Tartaro, Armando; Gallucci, M.; Uncini, Antonino

doi:10.1177/197140090902200106

Cited by 13 publications

(7 citation statements)

References 20 publications

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“…In one case, VitB1 was ineffective, but corticosteroid was effective for a short time, but the symptoms were returned to baseline levels soon. In one case who took a high dose of VitB1, the symptoms were improved, but severe disability still existed [16] [17] [22]. 4) Hepatitis C: This group contained one case of chronic Hepatitis C, involving entire corpus callosum and bilateral internal capsule, and one case of hepatitis C, cirrhosis and peritonitis, involving splenium of corpus callosum.…”

Section: Discussionmentioning

confidence: 99%

Alcoholic and Non-Alcoholic Marchiafava-Bignami Disease: A Comparative Study

Chen¹,

Wang²,

Wang³

et al. 2016

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Purpose: Marchiafava-Bignami Disease (MBD) is a rare condition mainly associated with alcoholism, although a few non-alcoholic cases have been reported. We performed a comparative study of demographic and clinical differences between alcoholic and non-alcoholic and assessed whether any treatment can be recommended. Methods: We reviewed 157 reports containing data on 168 subjects with Alcoholic MBD (AMBD) and 23 subjects with Non-Alcoholic MBD (NAMBD). The following data were extracted: demographic characteristics; delay from the onset of symptoms to admission; MRI features; location of the corpus callosum lesions; the presence of Wernicke's disease; drug treatment (thiamine, other vitamins and steroids); outcome. Results: The subjects with AMBD were more frequently men (84.5% vs 47.8, P = 0.000); the ones with AMBD were frequently reported as suffering from malnutrition (81.3% vs 50%, P = 0.019), whereas the NAMBD was frequently reported as suffering from diabetes mellitus (30.4% vs 7.1%, P = 0.002). The lesions in the NAMBD are often located in the splenium (47.8%), whereas single splenial lesions are seen only in 18.7% of the AMBD. 43.5% (10/23) of the NAMBD was reported to have recovered completely, whereas only 15.4% (24/156) AMBD showed a complete recovery. Conclusions: It is important to diagnose NAMBD in the early stage with MRI and to treat the symptoms with thiamine and/or corticosteroids according to aetiology. We recommend prompt treatment of MBD with parenteral thiamine in subjects associated with malnutrition, anorexia nervosa and prolonged vomiting, and reduction of food intake. Corticosteroids may aid in recovery by reducing oedema in subjects associated with diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Alcoholic and Non-Alcoholic Marchiafava-Bignami Disease: A Comparative Study

Chen¹,

Wang²,

Wang³

et al. 2016

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“…Common features of non-alcoholic MBD -according to a recent review -are female patients, young population, and those associated with malnutrition [7] , all of which were present in out patients, as well as the imaging study which shows selective engagement of the splenium of corpus callosum, also described in other cases of the disease without alcohol involvement [8] .…”

Section: Discussionmentioning

confidence: 99%

“…In turn, most of them showed selective compromise of the splenium of the corpus callosum [8] . So far both findings could be described as common characteristics of MRI in non-alcoholic MBD.…”

Section: Discussionmentioning

confidence: 99%

Marchiafava-Bignami's Disease, as Etiologic Diagnosis of Athetosis

Rivas

et al. 2017

Ann Neurosci

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“…It is considered a form of toxic demyelination seen in alcoholic patients, especially males between 40 and 60 years of age. MBD was observed in persons of all ethnic groups and drinking any type of alcoholic beverage, and even in rare nonalcoholic patients [4,5].…”

Section: Discussionmentioning

confidence: 99%

Marchiafava-Bignami Disease: Uncertain MRI Predictors of Outcome

Marchi¹,

Tondo²,

Varrasi³

et al. 2017

J Neurol Neurosci

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Marchiafava-Bignami disease (MBD) is a rare, often fatal, toxic neurological disease mainly characterized by demyelination of the corpus callosum, with or without associated lesions of hemispheric white matter. The clinical picture is severe, and includes both neuropsychiatric features, and signs of interhemispheric disconnection. The disease can have an acute or chronic course. Neuroimaging provides the most useful information for diagnosis and prognosis. We present a 44-year-old patient suffering from subacute onset of MBD, in who diffusion-weighted MRI revealed symmetrical hyperintense lesions in the frontal region of cerebral cortex and in the body/splenium of corpus callosum. Involvement of the corpus callosum was partial; the diagnosis was rather prompt, and the treatment was appropriated. The patient, survived to the acute phase, developed a chronic dementia.

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Non-Alcoholic Partially Reversible Marchiafava-Bignami Disease: Review and Relation with Reversible Splenial Lesions

Cited by 13 publications

References 20 publications

Alcoholic and Non-Alcoholic Marchiafava-Bignami Disease: A Comparative Study

Alcoholic and Non-Alcoholic Marchiafava-Bignami Disease: A Comparative Study

Marchiafava-Bignami's Disease, as Etiologic Diagnosis of Athetosis

Marchiafava-Bignami Disease: Uncertain MRI Predictors of Outcome

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