Non‐anaemic iron deficiency in <scp>COPD</scp>: A potential therapeutic target?

Boutou, Afroditi; Polkey, Michael I.; Hopkinson, Nicholas S

doi:10.1111/resp.12616

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…ID anemia occurs when ID is sufficiently severe to reduce erythropoiesis. Only a small percentage of patients with COPD with ID present with concurrent anemia, suggesting that these two entities should be considered separately (95). See Table E2 for studies related to ID and anemia in COPD.…”

Section: Prevalence Of Anemia and Id In Copdmentioning

confidence: 99%

The “Iron”-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease

Cloonan

Mumby²,

Adcock³

et al. 2017

Am J Respir Crit Care Med

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Section: Prevalence Of Anemia and Id In Copdmentioning

confidence: 99%

The “Iron”-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease

Cloonan

Mumby²,

Adcock³

et al. 2017

Am J Respir Crit Care Med

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“…The chronic inflammation in COPD is considered to be the main cause of iron deficiency and/or anaemia development in COPD patients, although not the only cause 1,6,7 . Nutritional deficiencies, underlying chronic conditions or different treatment approaches also impact development of anaemia either alone or together with inflammation‐based mechanisms 1,8 .…”

Section: Introductionmentioning

confidence: 99%

Iron deficiency in nonanaemic COPD patients—Could Low haemoglobin density and Microcytic anaemia factor be usefull?

Trtica

Milenković

Janković

et al. 2023

Int J Lab Hematology

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Introduction: Erythrocyte indices LHD and Maf are complementary parameters to complete blood count and have been shown as reliable iron deficiency markers in different clinical settings. The aim of the study was to assess diagnostic performances of LHD and Maf in detecting iron deficiency in nonanaemic stable COPD patients.Methods: A total of 93 nonanaemic stable COPD patients were classified as either iron deficient (ID, N = 15) or non-iron deficient (non-ID, N = 78). Iron deficiency was defined as a ferritin level < 100 μg/L with a transferrin saturation (TSAT) <20%.A complete blood count, including LHD and Maf as well as other relevant inflammation and iron status parameters were obtained for all participants.Results: Both LHD and Maf have shown significant differences between the ID and non-ID group with p = .003 and p = .007 respectively. The AUC for LHD was .744 (95% CI: .626-.863, p = .003) with the best cut-off of 5.85 and sensitivity of 80% (95% CI: 76.0-84.0) and specificity of 61.5% (95% CI: 58.4-64.6). The AUC for Maf was .707 with optimal cut-off value 12.65 and sensitivity of 83.3% (95% CI: 79.1-87.5) and specificity of 60.0% (95% CI: 57.0-63.0). Furthermore, LHD performance was not affected by vitamin B12 status.Conclusion: LHD and Maf are useful for iron deficiency diagnosis in stable COPD patients. LHD was shown to be resistant to vitamin B12 deficiency, which is of substantial importance in specific patient subpopulations. Both parameters are not technology-dependant and do not require additional sample and/or reagent volume, which makes them cost-effective and convenient for everyday use.

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Intravenous Iron Replacement Improves Exercise Tolerance in COPD: A Single-Blind Randomized Trial

Martín-Ontiyuelo

Rodó-Pin

Echeverría-Esnal

et al. 2022

Archivos de Bronconeumología

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Non‐anaemic iron deficiency in COPD: A potential therapeutic target?

Abstract: See article, page 1089

Cited by 3 publications

References 14 publications

The “Iron”-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease

The “Iron”-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease

Iron deficiency in nonanaemic COPD patients—Could Low haemoglobin density and Microcytic anaemia factor be usefull?

Intravenous Iron Replacement Improves Exercise Tolerance in COPD: A Single-Blind Randomized Trial

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